Dual-modality immune nano-activator harnessing Mn2⁺ and quercetin to potentiate the cGAS-STING pathway for advanced cancer metalloimmunotherapy

Abstract Manganese ions (Mn2+) have emerged as promising activators of the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway. However, their clinical application was hindered by low bioavailability and limited immune activation pathways, which impaired their ability to trig...

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Bibliographic Details
Published in:	Journal of Nanobiotechnology
Main Authors:	Shanshan Ma, Xuequan Zhang, Xiaoqi Zhu, Kangning Yan, Qin Wang, Lei Lei, Jiasheng Li, Jing Guo, Weizhong Tang, Junjie Liu, Jun Cao, Duo Wang, Tao Luo
Format:	Article
Language:	English
Published:	BMC 2025-03-01
Subjects:	cGAS-STING Quercetin Manganese ions Photothermal therapy Metalloimmunotherapy
Online Access:	https://doi.org/10.1186/s12951-025-03336-8

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