Loss of BCAA catabolism enhances Rab1A-mTORC1 signaling activity and promotes tumor proliferation in NSCLC

Background: Non-small cell lung cancer (NSCLC) is a leading cause of cancer death. Branched-chain amino acid (BCAA) homeostasis is important for normal physiological metabolism. Branched-chain keto acid dehydrogenase kinase (BCKDK) is a rate-limiting enzyme involved in BCAA degradation. BCAA metabol...

Full description

Bibliographic Details
Published in:	Translational Oncology
Main Authors:	Meiting Xue, Jiawei Xiao, Wenna Jiang, Yanhui Wang, Duo Zuo, Haohua An, Li Ren
Format:	Article
Language:	English
Published:	Elsevier 2023-08-01
Subjects:	BCAA catabolism BCKDK Rab1A mTORC1 NSCLC
Online Access:	http://www.sciencedirect.com/science/article/pii/S1936523323000827

Similar Items

Increased Rab1a accelerates osteoarthritis by inhibiting autophagy via activation of the mTORC1-S6K pathway
by: Ze Chen, et al.
Published: (2025-09-01)

RAB3B Dictates mTORC1/S6 Signaling in Chordoma and Predicts Response to mTORC1‐Targeted Therapy
by: Jianxuan Gao, et al.
Published: (2025-05-01)

Repletion of branched chain amino acids reverses mTORC1 signaling but not improved metabolism during dietary protein dilution
by: Adriano Maida, et al.
Published: (2017-08-01)

Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2
by: Polina Kosillo, et al.
Published: (2022-07-01)

mTORC1 and mTORC2 Levels in Patients With Psoriasis
by: İlayda Esna Gülsunay, et al.
Published: (2024-10-01)

Evaluation of therapeutic strategies targeting BCAA catabolism using a systems pharmacology model
by: Veronika Voronova, et al.
Published: (2022-11-01)

Elevated BCAA catabolism reverses the effect of branched-chain ketoacids on glucose transport in mTORC1-dependent manner in L6 myotubes
by: Gagandeep Mann, et al.
Published: (2024-01-01)

Partial suppression of BCAA catabolism as a potential therapy for BCKDK deficiency
by: Laura Ohl, et al.
Published: (2024-06-01)

mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system
by: Linqing Miao, et al.
Published: (2016-03-01)

mTORC1 signaling in hepatic lipid metabolism
by: Jinbo Han, et al.
Published: (2017-04-01)

LPS Induces mTORC1 and mTORC2 Activation During Monocyte Adhesion
by: Marcelle C. Ribeiro, et al.
Published: (2018-07-01)

TPC1 regulates melanoma tumourigenesis via mTORC1 and TFEB
by: Xuhui Jin, et al.
Published: (2024-11-01)

Role of FLCN Phosphorylation in Insulin‐Mediated mTORC1 Activation and Tumorigenesis
by: Guoyan Wang, et al.
Published: (2023-06-01)

TFEB-mTORC1 feedback loop in metabolism and cancer
by: Chiara Di Malta, et al.
Published: (2017-10-01)

Modulation of mTORC1 Signaling Pathway by HIV-1
by: Burkitkan Akbay, et al.
Published: (2020-04-01)

Novel mTORC1 Inhibitors Kill Glioblastoma Stem Cells
by: Jose A. Sandoval, et al.
Published: (2020-11-01)

Autophagy: Are Amino Acid Signals Dependent on the mTORC1 Pathway or Independent?
by: Chenglong Jin, et al.
Published: (2024-08-01)

mTORC1-selective inhibitors rescue cellular phenotypes in TSC iPSC-derived neurons
by: Elizabeth D. Buttermore, et al.
Published: (2025-07-01)

mTORC1 hyperactivation and resultant suppression of macroautophagy contribute to the induction of cardiomyocyte necroptosis by catecholamine surges
by: Mingqi Cai, et al.
Published: (2024-03-01)

Disrupted cardiac fibroblast BCAA catabolism contributes to diabetic cardiomyopathy via a periostin/NAP1L2/SIRT3 axis
by: Qing-Bo Lu, et al.
Published: (2023-11-01)

Transient Inhibition of mTORC1 Signaling Ameliorates Irradiation-Induced Liver Damage
by: Wuping Yang, et al.
Published: (2019-03-01)

mTORC2: a multifaceted regulator of autophagy
by: Yanan Sun, et al.
Published: (2023-01-01)

Comprehensive Analysis of mTORC1 Signaling Pathway–Related Genes in the Prognosis of HNSCC and the Response to Chemotherapy and Immunotherapy
by: Zhao Ding, et al.
Published: (2022-04-01)

Cryptotanshinone activates AMPK-TSC2 axis leading to inhibition of mTORC1 signaling in cancer cells
by: Wenxing Chen, et al.
Published: (2017-01-01)

Chlorpromazine affects autophagy in association with altered Rag GTPase–mTORC1–TFEB signaling
by: Ningning Li, et al.
Published: (2023-09-01)

An mTORC1‐Dependent Mouse Model for Cardiac Sarcoidosis
by: Carlos Bueno‐Beti, et al.
Published: (2023-10-01)

Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2
by: Lan eYe, et al.
Published: (2012-09-01)

TSC-mTORC1 Pathway in Postnatal V-SVZ Neurodevelopment
by: David M. Feliciano, et al.
Published: (2025-04-01)

mTORC1 pathway activity biases cell fate choice
by: Yuntao Wang, et al.
Published: (2024-09-01)

Metformin induces ZFP36 by mTORC1 inhibition in cervical cancer-derived cell lines
by: Karen Griselda De la Cruz-López, et al.
Published: (2024-07-01)

Microglial SIRT1 activation attenuates synapse loss in retinal inner plexiform layer via mTORC1 inhibition
by: Ke Yao, et al.
Published: (2023-09-01)

Disruption of the Keap1-mTORC2 axis by cancer-derived Keap1/mLST8 mutations leads to oncogenic mTORC2-AKT activation
by: Yingji Chen, et al.
Published: (2023-11-01)

mTORC1 Mediates Biphasic Mechano‐Response to Orchestrate Adhesion‐Dependent Cell Growth and Anoikis Resistance
by: Chunlei Zhang, et al.
Published: (2024-02-01)

The Multifaceted Role of Nutrient Sensing and mTORC1 Signaling in Physiology and Aging
by: Stephanie A. Fernandes, et al.
Published: (2021-08-01)

Palmitate Inhibits Mouse Macrophage Efferocytosis by Activating an mTORC1-Regulated Rho Kinase 1 Pathway: Therapeutic Implications for the Treatment of Obesity
by: László Sós, et al.
Published: (2022-11-01)

Positive and Negative Regulation of the Master Metabolic Regulator mTORC1 by Two Families of Legionella pneumophila Effectors
by: Justin A. De Leon, et al.
Published: (2017-11-01)

Branched‐Chain Amino Acid Accumulation Fuels the Senescence‐Associated Secretory Phenotype
by: Yaosi Liang, et al.
Published: (2024-01-01)

OTUD3 suppresses the mTORC1 signaling by deubiquitinating KPTN
by: Jiatao Li, et al.
Published: (2024-01-01)

Vaccinia growth factor-dependent modulation of the mTORC1-CAD axis upon nutrient restriction
by: Lara Dsouza, et al.
Published: (2025-02-01)

mTORC1 Activity in Psoriatic Lesions Is Mediated by Aberrant Regulation through the Tuberous Sclerosis Complex
by: Antonio Ferreri, et al.
Published: (2022-09-01)