An antimicrobial alkaloid and other metabolites produced by Penicillium sp. An endophytic fungus isolated from Mauritia flexuosa L. f.

• Published in: Química Nova
• Main Authors: Hector Henrique Ferreira Koolen, Elzalina Ribeiro Soares, Felipe Moura Araújo da Silva, Richardson Alves de Almeida, Afonso Duarte Leão de Souza, Lívia Soman de Medeiros, Edson Rodrigues Filho, Antonia Queiroz Lima de Souza
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Química 2012-01-01
• Subjects: Penicillium; Mauritia flexuosa; glandicoline B
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000400022&lng=en&tlng=en

The alkaloid glandicoline B (1) and six other compounds: ergosterol (2), brassicasterol (3), ergosterol peroxide (4), cerevisterol (5), mannitol (6) and 1-O-α-D-glucopyranoside (7) were isolated from Penicillium sp. strain PBR.2.2.2, a fungus from Mauritia flexuosa roots. The structures of the isolated metabolites were established by spectral analysis. MeOH extract of the fungal mycelium at 500 µg mL-1 exhibited antimicrobial activity against Staphylococcus aureus and the compound 1 at 100 µg mL-1 was active against S. aureus, Micrococcus luteus and Escherichia coli. The relationship between the bioactive properties of the fungus PBR.2.2.2 and those achieved for glandicoline B, as well the potential of this substance as bactericide is discussed.