Overview of the Anticancer Potential of the “King of Spices” <i>Piper nigrum</i> and Its Main Constituent Piperine

The main limits of current anticancer therapy are relapses, chemoresistance, and toxic effects resulting from its poor selectivity towards cancer cells that severely impair a patient’s quality of life. Therefore, the discovery of new anticancer drugs remains an urgent challenge. Natural products rep...

Full description

Bibliographic Details
Published in:	Toxins
Main Authors:	Eleonora Turrini, Piero Sestili, Carmela Fimognari
Format:	Article
Language:	English
Published:	MDPI AG 2020-11-01
Subjects:	<i>Piper nigrum</i> piperine cancer therapy anticancer mechanisms in vitro studies in vivo studies
Online Access:	https://www.mdpi.com/2072-6651/12/12/747

Similar Items

Comparative Quantification of the Phenolic Compounds, Piperine Content, and Total Polyphenols along with the Antioxidant Activities in the <i>Piper trichostachyon</i> and <i>P. nigrum</i>
by: Jameel Mohammed Al-Khayri, et al.
Published: (2022-09-01)

Combining Normal/Reversed-Phase HPTLC with Univariate Calibration for the Piperine Quantification with Traditional and Ultrasound-Assisted Extracts of Various Food Spices of <i>Piper nigrum</i> L. under Green Analytical Chemistry Viewpoint
by: Mohammed H. Alqarni, et al.
Published: (2021-01-01)

Phytochemistry and therapeutic potential of black pepper [Piper nigrum (L.)] essential oil and piperine: a review
by: Kaliyaperumal Ashokkumar, et al.
Published: (2021-06-01)

<i>Piper nigrum</i> CYP719A37 Catalyzes the Decisive Methylenedioxy Bridge Formation in Piperine Biosynthesis
by: Arianne Schnabel, et al.
Published: (2021-01-01)

Piperine Derived from <i>Piper nigrum</i> L. Inhibits LPS-Induced Inflammatory through the MAPK and NF-κB Signalling Pathways in RAW264.7 Cells
by: Zhouwei Duan, et al.
Published: (2022-09-01)

‘Priming’ protects Piper nigrum L. from Phytophthora capsici through reinforcement of phenylpropanoid pathway and possible enhancement of Piperine biosynthesis
by: M. Indu, et al.
Published: (2022-12-01)

Characterization and Isolation of Piperamides from <i>Piper nigrum</i> Cultivated in Costa Rica
by: Luis Felipe Vargas-Huertas, et al.
Published: (2023-12-01)

Evaluation of Antimicrobial Activity and Cytotoxicity Effects of Extracts of <i>Piper nigrum</i> L. and Piperine
by: Fabrine Silva Alves, et al.
Published: (2022-12-01)

Application of Non-Destructive Rapid Determination of Piperine in <i>Piper nigrum</i> L. (Black Pepper) Using NIR and Multivariate Statistical Analysis: A Promising Quality Control Tool
by: Jong-Rak Park, et al.
Published: (2020-10-01)

Experimental Characterization of the Drying of Kampot Red Pepper (<i>Piper nigrum</i> L.)
by: Elen Morm, et al.
Published: (2020-10-01)

Piperine: A Mini Review on its Pharmacological Profile and Synthetic Derivatives
by: Mohd. Javed Naim, et al.
Published: (2022-12-01)

Evaluation of histone deacetylase inhibitory and antiproliferative activity of piperine and its derivatives
by: La-or Somsakeesit, et al.
Published: (2022-12-01)

<i>Piper nigrum</i> Extract: Dietary Supplement for Reducing Mammary Tumor Incidence and Chemotherapy-Induced Toxicity
by: Nadeeya Mad-adam, et al.
Published: (2023-05-01)

Biological Activities and Chemical Constituents of Essential Oils from <i>Piper cubeba</i> Bojer and <i>Piper nigrum</i> L.
by: Yusuf Andriana, et al.
Published: (2019-05-01)

Volatiles of Black Pepper Fruits (<i>Piper nigrum </i>L.)
by: Noura S. Dosoky, et al.
Published: (2019-11-01)

Innovative Green Approach for Extraction of Piperine from Black Pepper Based on Response Surface Methodology
by: Charles Lwamba, et al.
Published: (2023-01-01)

<i>Piper nigrum</i> Fruit Extract as an Antibiotic Resistance Reversal Agent in MDR Bacteria
by: Maryam Salah Ud Din, et al.
Published: (2022-12-01)

Antimicrobial activity of Curcuma longa L., Capsicum annuum L. and Piper nigrum at different conditions
by: Hoorieh Sadat Mairmalek-Sani, et al.
Published: (2020-06-01)

Biodefensive Based on <i>Piper nigrum</i> Essential Oil for Controlling of <i>Anopheles aquasalis</i> Larvae: Influence of Temperature (35 °C) and Preservatives
by: Ayná Caroline Marcião Vieira, et al.
Published: (2022-11-01)

Comparison of piperine content, antimicrobial and antioxidant activity of Piper chaba root and stem
by: Md Rubel Al-Mamun, et al.
Published: (2024-10-01)

Antimicrobial activities of Calligonum polygonoides, Albezia lebeck and Piper nigrum
by: Arif Khan, et al.
Published: (2015-06-01)

Essential Oil Components and Antitrichomonal Effects of Piper nigrum L.
by: Ali Jamshidi-zad, et al.
Published: (2023-08-01)

Effects of <i>Piper nigrum</i> L. Fruit Essential Oil Toxicity against Stable Fly (Diptera: Muscidae)
by: Thekhawet Weluwanarak, et al.
Published: (2023-02-01)

Effects of <i>Piper betle</i> Extracts against Biofilm Formation by Methicillin-Resistant <i>Staphylococcus pseudintermedius</i> Isolated from Dogs
by: Arpron Leesombun, et al.
Published: (2023-05-01)

Chemical Profiling, Formulation Development, <i>In Vitro</i> Evaluation and Molecular Docking of <i>Piper nigrum</i> Seeds Extract Loaded Emulgel for Anti-Aging
by: Muhammad Yousuf, et al.
Published: (2022-09-01)

<i>Piper nigrum</i> Extract Inhibits the Growth of Human Colorectal Cancer HT-29 Cells by Inducing p53-Mediated Apoptosis
by: Rui Wu, et al.
Published: (2023-09-01)

Evaluation of Analgesic Properties of Piper Nigrum Essential Oil: a Randomized, Double-blind, Placebo-controlled Study
by: R. Costa, et al.
Published: (2016-08-01)

Efficiency of Ozone Applied in Flow and at Low Pressures in the Inactivation of <i>Salmonella</i> in Black Peppercorns (<i>Piper nigrum</i> L.) and the Effects of Ozone Treatment on Grain Quality and Essential Oil Composition
by: Handina da Graça Lurdes Langa Massango, et al.
Published: (2025-06-01)

Quorum Sensing and NF-κB Inhibition of Synthetic Coumaperine Derivatives from <i>Piper nigrum</i>
by: Yael Kadosh, et al.
Published: (2021-04-01)

Evaluation of Anti-<i>Candida</i> Potential of <i>Piper nigrum</i> Extract in Inhibiting Growth, Yeast-Hyphal Transition, Virulent Enzymes, and Biofilm Formation
by: Claudia Patrícia Bravo-Chaucanés, et al.
Published: (2022-07-01)

Analgesic effect of hydroalcoholic extract of Zingiber and piper nigrum in mice by tail-flick test
by: M.R H EIDARI, et al.
Published: (1997-07-01)

Comparative evaluation of the potential anti-spasmodic activity of Piper longum, Piper nigrum, Terminalia bellerica, Terminalia chebula, and Zingiber officinale in experimental animals
by: Bansilal R. Tiwari, et al.
Published: (2023-09-01)

Piperine reduces hair oiliness by inhibiting adipogenesis of hair stem cells
by: Minyoung Im, et al.
Published: (2024-04-01)

Isolation and Characterization of the Bioactive Compound of Piperine in Black Pepper (Piper nigrum L.)
by: Nora Listantia, et al.
Published: (2021-12-01)

Anxiolytic and thrombolytic investigation of methanol extract of Piper nigrum L. fruits and Sesamum indicum L. seeds
by: Nazim Uddin Emon, et al.
Published: (2020-12-01)

Piperine as a phytogenic additive in broiler diets
by: Verônica da Silva Cardoso, et al.
Published: (2012-04-01)

Chemical composition of essential oil in Piper nigrum from Nigeria and its bioactivity against stored-grain insects
by: Kehinde Adenike Oyewole, et al.
Published: (2023-06-01)

Phytochemical analysis and synergistic memory enhancing effect of Bacopa monnieri with Piper nigrum
by: Sourabh Jain, et al.
Published: (2025-03-01)

De novo transcriptome profiling revealing genes involved in piperine biosynthetic pathway in Piper longum L
by: Mrinalini Prasad, et al.
Published: (2025-01-01)

Edible Plant Extracts against <i>Aedes aegypti</i> and Validation of a <i>Piper nigrum</i> L. Ethanolic Extract as a Natural Insecticide
by: Lais Silva Morais, et al.
Published: (2023-01-01)