Advancing Allogeneic NK Cell Immunotherapy through Microfluidic Gene Delivery

Abstract Chimeric antigen receptor (CAR)‐T cell therapy has revolutionized cancer treatment, yet challenges such as manufacturing complexity, high costs, and safety concerns have spurred the development of alternatives like CAR‐natural killer (NK) cell immunotherapies. CAR‐NK cell therapies provide...

Full description

Bibliographic Details
Published in:	Advanced Science
Main Authors:	Hyelee Kim, Mujin Lee, Bohwa Han, Jinho Kim, Duck Cho, Junsang Doh, Aram J. Chung
Format:	Article
Language:	English
Published:	Wiley 2025-05-01
Subjects:	allogeneic cell therapy CAR‐NK CRISPR gene delivery microfluidics NK cell‐based immunotherapy
Online Access:	https://doi.org/10.1002/advs.202412544

Similar Items

New Orders to an Old Soldier: Optimizing NK Cells for Adoptive Immunotherapy in Hematology
by: Mehmet Gunduz, et al.
Published: (2021-09-01)

DNAM-1 chimeric receptor-engineered NK cells: a new frontier for CAR-NK cell-based immunotherapy
by: Loredana Cifaldi, et al.
Published: (2023-06-01)

NK cell-based tumor immunotherapy
by: Hao Zhang, et al.
Published: (2024-01-01)

LLT1 overexpression renders allogeneic-NK resistance and facilitates the generation of enhanced universal CAR-T cells
by: Shuxian Zhu, et al.
Published: (2025-01-01)

Novel strategies to overcome tumor immunotherapy resistance using CAR NK cells
by: Jun-Hui Guo, et al.
Published: (2025-05-01)

CRISPR, CAR-T, and NK: Current applications and future perspectives
by: Mohadeseh Khoshandam, et al.
Published: (2024-07-01)

Immunotherapy of chimeric antigen receptor NK cells: status and its promising future
by: Fang Wang, et al.
Published: (2025-10-01)

Role of NK Cells in Progression and Treatment of Multiple Myeloma
by: Iman Chanchiri, et al.
Published: (2025-04-01)

NK cells in renal cell carcinoma and its implications for CAR-NK therapy
by: Xinwei Li, et al.
Published: (2025-02-01)

Immunotherapy of B cell lymphoma with CD22-redirected CAR NK-92 cells
by: Xiaopeng Tian, et al.
Published: (2023-04-01)

Immunotherapy with NK cells: recent developments in gene modification open up new avenues
by: Lisa Marie Reindl, et al.
Published: (2020-01-01)

<i>shp-2</i> gene knockout upregulates CAR-driven cytotoxicity of YT NK cells
by: V. G. Subrakova, et al.
Published: (2020-03-01)

Renaissance of armored immune effector cells, CAR-NK cells, brings the higher hope for successful cancer therapy
by: Faroogh Marofi, et al.
Published: (2021-03-01)

CAR-NK cell therapy: promise and challenges in solid tumors
by: Sahar Balkhi, et al.
Published: (2025-04-01)

Overcoming Immune Barriers in Allogeneic CAR-NK Therapy: From Multiplex Gene Editing to AI-Driven Precision Design
by: Hyunyoung Kim
Published: (2025-06-01)

Chimeric antigen receptor-natural killer (CAR-NK) cell immunotherapy: A bibliometric analysis from 2004 to 2023
by: Wangshu Li, et al.
Published: (2024-12-01)

Enhancing a Natural Killer: Modification of NK Cells for Cancer Immunotherapy
by: Rasa Islam, et al.
Published: (2021-04-01)

Editorial: Cancer immunotherapies for hematologic malignancies - NK/CIK/CAR-T perspective
by: Amit Sharma, et al.
Published: (2024-06-01)

Outsmarting trogocytosis to boost CAR NK/T cell therapy
by: Faezeh Ramezani, et al.
Published: (2023-11-01)

Autologous, allogeneic hematopoietic cell transplantation and CAR-T/NK therapy: what is their real importance in PTCL?
by: Samuel C. F. Couto, et al.
Published: (2023-08-01)

Advances in CAR-NK cell therapy for hematological malignancies
by: Rui Yang, et al.
Published: (2024-06-01)

CAR NK Cell Therapy for the Treatment of Metastatic Melanoma: Potential & Prospects
by: Winston Hibler, et al.
Published: (2023-11-01)

Analysis of the impact of handling and culture on the expansion and functionality of NK cells
by: Sara Martin-Iglesias, et al.
Published: (2023-08-01)

CAR-T Cells/-NK Cells in Cancer Immunotherapy and the Potential of MSC to Enhance Its Efficacy: A Review
by: Ler Yie Chan, et al.
Published: (2022-03-01)

Recent Advances to Augment NK Cell Cancer Immunotherapy Using Nanoparticles
by: Kwang-Soo Kim, et al.
Published: (2021-04-01)

Allogeneic CAR-engineered cellular therapy for relapsed and refractory large B cell lymphoma: a systematic review and meta-analysis
by: Alexander Biederstädt, et al.
Published: (2025-07-01)

Chasing Uterine Cancer with NK Cell-Based Immunotherapies
by: Vijay Kumar, et al.
Published: (2022-12-01)

Potentiation of natural killer cells to overcome cancer resistance to NK cell-based therapy and to enhance antibody-based immunotherapy
by: Massimo Fantini, et al.
Published: (2023-11-01)

Superior Expansion and Cytotoxicity of Human Primary NK and CAR-NK Cells from Various Sources via Enriched Metabolic Pathways
by: Yan Yang, et al.
Published: (2020-09-01)

Intrathecal CAR-NK cells infusion for isolated CNS relapse after allogeneic stem cell transplantation: case report
by: Jing Yuan, et al.
Published: (2023-03-01)

NK Cell-Based Immunotherapy in Colorectal Cancer
by: Mariella Della Chiesa, et al.
Published: (2022-06-01)

Harnessing natural killer cells to develop next‐generation cellular immunotherapy
by: Siyao Liu, et al.
Published: (2022-12-01)

Harnessing the Potential of NK Cell-Based Immunotherapies against Multiple Myeloma
by: Chantal Reina-Ortiz, et al.
Published: (2022-01-01)

CAR-NK Cell Therapy: A Transformative Approach to Overcoming Oncological Challenges
by: Wangshu Li, et al.
Published: (2024-08-01)

Optimizing the cryopreservation and post-thaw recovery of natural killer cells is critical for the success of off-the-shelf platforms
by: Jennifer N. Saultz, et al.
Published: (2023-12-01)

Clinical trials of nanoparticle-enhanced CAR-T and NK cell therapies in oncology: overcoming translational and clinical challenges - a mini review
by: Xiaoqian Zhao, et al.
Published: (2025-08-01)

The Rise of NK Cell Checkpoints as Promising Therapeutic Targets in Cancer Immunotherapy
by: Haoyu Sun, et al.
Published: (2019-10-01)

CAR-NK cells for gastrointestinal cancer immunotherapy: from bench to bedside
by: Xingwang Zhu, et al.
Published: (2024-10-01)

Current trends and future of gene-cell immunotherapy in the treatment of HIV infection
by: A. P. Faenko, et al.
Published: (2025-05-01)

Antitumor activity of genetically engineered NK-cells in non-hematological solid tumor: a comprehensive review
by: Chinmayee Priyadarsini Dash, et al.
Published: (2024-04-01)