Rewired m6A epitranscriptomic networks link mutant p53 to neoplastic transformation
The dysregulation of the m6A epitranscriptomic networks have been reported to contribute to the development of gliomas. Here, the authors utilize induced pluripotent stem cell-derived astrocytes with a p53 mutation and demonstrate that mutant p53 upregulates the m6A reader YTHDF2, resulting in the i...
| Published in: | Nature Communications |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-03-01
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| Online Access: | https://doi.org/10.1038/s41467-023-37398-9 |
| _version_ | 1850143758146863104 |
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| author | An Xu Mo Liu Mo-Fan Huang Yang Zhang Ruifeng Hu Julian A. Gingold Ying Liu Dandan Zhu Chian-Shiu Chien Wei-Chen Wang Zian Liao Fei Yuan Chih-Wei Hsu Jian Tu Yao Yu Taylor Rosen Feng Xiong Peilin Jia Yi-Ping Yang Danielle A. Bazer Ya-Wen Chen Wenbo Li Chad D. Huff Jay-Jiguang Zhu Francesca Aguilo Shih-Hwa Chiou Nathan C. Boles Chien-Chen Lai Mien-Chie Hung Zhongming Zhao Eric L. Van Nostrand Ruiying Zhao Dung-Fang Lee |
| author_facet | An Xu Mo Liu Mo-Fan Huang Yang Zhang Ruifeng Hu Julian A. Gingold Ying Liu Dandan Zhu Chian-Shiu Chien Wei-Chen Wang Zian Liao Fei Yuan Chih-Wei Hsu Jian Tu Yao Yu Taylor Rosen Feng Xiong Peilin Jia Yi-Ping Yang Danielle A. Bazer Ya-Wen Chen Wenbo Li Chad D. Huff Jay-Jiguang Zhu Francesca Aguilo Shih-Hwa Chiou Nathan C. Boles Chien-Chen Lai Mien-Chie Hung Zhongming Zhao Eric L. Van Nostrand Ruiying Zhao Dung-Fang Lee |
| author_sort | An Xu |
| collection | DOAJ |
| container_title | Nature Communications |
| description | The dysregulation of the m6A epitranscriptomic networks have been reported to contribute to the development of gliomas. Here, the authors utilize induced pluripotent stem cell-derived astrocytes with a p53 mutation and demonstrate that mutant p53 upregulates the m6A reader YTHDF2, resulting in the initiation of gliomas. |
| format | Article |
| id | doaj-art-e94f230ab56e49dfb83c91e1ccf71c9f |
| institution | Directory of Open Access Journals |
| issn | 2041-1723 |
| language | English |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| spelling | doaj-art-e94f230ab56e49dfb83c91e1ccf71c9f2025-08-19T23:48:13ZengNature PortfolioNature Communications2041-17232023-03-0114111910.1038/s41467-023-37398-9Rewired m6A epitranscriptomic networks link mutant p53 to neoplastic transformationAn Xu0Mo Liu1Mo-Fan Huang2Yang Zhang3Ruifeng Hu4Julian A. Gingold5Ying Liu6Dandan Zhu7Chian-Shiu Chien8Wei-Chen Wang9Zian Liao10Fei Yuan11Chih-Wei Hsu12Jian Tu13Yao Yu14Taylor Rosen15Feng Xiong16Peilin Jia17Yi-Ping Yang18Danielle A. Bazer19Ya-Wen Chen20Wenbo Li21Chad D. Huff22Jay-Jiguang Zhu23Francesca Aguilo24Shih-Hwa Chiou25Nathan C. Boles26Chien-Chen Lai27Mien-Chie Hung28Zhongming Zhao29Eric L. Van Nostrand30Ruiying Zhao31Dung-Fang Lee32Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at HoustonDepartment of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at HoustonDepartment of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at HoustonCollege of Science, Harbin Institute of Technology (Shenzhen)Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at HoustonDepartment of Obstetrics & Gynecology and Women’s Health, Einstein/Montefiore Medical CenterDepartment of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at HoustonDepartment of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at HoustonDepartment of Medical Research, Taipei Veterans General HospitalInstitute of Molecular Biology, National Chung Hsing UniversityVerna & Marrs McLean Department of Biochemistry & Molecular Biology and Therapeutic Innovation Center, Baylor College of MedicineVerna & Marrs McLean Department of Biochemistry & Molecular Biology and Therapeutic Innovation Center, Baylor College of MedicineDepartment of Molecular Physiology and Biophysics, Baylor College of MedicineDepartment of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at HoustonDepartment of Epidemiology, The University of Texas MD Anderson Cancer CenterDepartment of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at HoustonDepartment of Biochemistry and Molecular Biology, McGovern Medical School, The University of Texas Health Science Center at HoustonCenter for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at HoustonDepartment of Medical Research, Taipei Veterans General HospitalDepartment of Neurology, Renaissance School of Medicine at Stony Brook UniversityDepartment of Otolaryngology, Icahn School of Medicine at Mount SinaiThe University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical SciencesThe University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical SciencesDepartment of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at HoustonWallenberg Centre for Molecular Medicine (WCMM), Umea UniversityDepartment of Medical Research, Taipei Veterans General HospitalNeural Stem Cell InstituteInstitute of Molecular Biology, National Chung Hsing UniversityGraduate Institute of Biomedical Sciences and Center for Molecular Medicine, and Office of the President, China Medical UniversityThe University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical SciencesVerna & Marrs McLean Department of Biochemistry & Molecular Biology and Therapeutic Innovation Center, Baylor College of MedicineDepartment of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at HoustonDepartment of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at HoustonThe dysregulation of the m6A epitranscriptomic networks have been reported to contribute to the development of gliomas. Here, the authors utilize induced pluripotent stem cell-derived astrocytes with a p53 mutation and demonstrate that mutant p53 upregulates the m6A reader YTHDF2, resulting in the initiation of gliomas.https://doi.org/10.1038/s41467-023-37398-9 |
| spellingShingle | An Xu Mo Liu Mo-Fan Huang Yang Zhang Ruifeng Hu Julian A. Gingold Ying Liu Dandan Zhu Chian-Shiu Chien Wei-Chen Wang Zian Liao Fei Yuan Chih-Wei Hsu Jian Tu Yao Yu Taylor Rosen Feng Xiong Peilin Jia Yi-Ping Yang Danielle A. Bazer Ya-Wen Chen Wenbo Li Chad D. Huff Jay-Jiguang Zhu Francesca Aguilo Shih-Hwa Chiou Nathan C. Boles Chien-Chen Lai Mien-Chie Hung Zhongming Zhao Eric L. Van Nostrand Ruiying Zhao Dung-Fang Lee Rewired m6A epitranscriptomic networks link mutant p53 to neoplastic transformation |
| title | Rewired m6A epitranscriptomic networks link mutant p53 to neoplastic transformation |
| title_full | Rewired m6A epitranscriptomic networks link mutant p53 to neoplastic transformation |
| title_fullStr | Rewired m6A epitranscriptomic networks link mutant p53 to neoplastic transformation |
| title_full_unstemmed | Rewired m6A epitranscriptomic networks link mutant p53 to neoplastic transformation |
| title_short | Rewired m6A epitranscriptomic networks link mutant p53 to neoplastic transformation |
| title_sort | rewired m6a epitranscriptomic networks link mutant p53 to neoplastic transformation |
| url | https://doi.org/10.1038/s41467-023-37398-9 |
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