A scoping review of imatinib-induced testicular toxicity and male fertility impairment

BackgroundImatinib, the first-generation tyrosine kinase inhibitor (TKI), has been widely adopted as frontline therapy for chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GIST). Growing evidence indicates potential gonadotoxic effects, raising concerns about its long-term impact...

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Bibliographic Details

Published in:	Frontiers in Endocrinology
Main Authors:	Xia Ji, Mohd Faizal Ahmad, Mohd Helmy Mokhtar, XiaoYing He, Abdul Kadir Abdul Karim
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2026-05-01
Subjects:	fertility preservation imatinib mesylate spermatogenesis testicular diseases testis/drug effects
Online Access:	https://www.frontiersin.org/articles/10.3389/fendo.2026.1811653/full