The effect of fucoxanthin on the development of CCl<sub>4</sub>-induced liver fibrosis

Background. According to current concepts regarding hepatic fibrosis, myofibroblast differentiation from stellate cells, regulated by transforming growth factor-β (TGF-β), is a key step in its pathogenesis. Hence, inhibition of TGF-β-dependent activation of hepatic stellate cells has been suggested...

Full description

Bibliographic Details
Published in:	Фундаментальная и клиническая медицина
Main Authors:	V. N. Slautin, D. Yu. Grebnev, I. Yu. Maklakova, S. V. Sazonov, I. V. Gavrilov, E. I. Gavrilova
Format:	Article
Language:	Russian
Published:	Kemerovo State Medical University 2023-06-01
Subjects:	fucoxanthin liver fibrosis hepatic stellate cells myofibroblasts
Online Access:	https://fcm.kemsmu.ru/jour/article/view/710

Similar Items

Single Cell RNA Sequencing Identifies Subsets of Hepatic Stellate Cells and Myofibroblasts in Liver Fibrosis
by: Oliver Krenkel, et al.
Published: (2019-05-01)

Noncoding RNA-Mediated Epigenetic Regulation in Hepatic Stellate Cells of Liver Fibrosis
by: Ruoyu Gao, et al.
Published: (2024-08-01)

TGF-β in Hepatic Stellate Cell Activation and Liver Fibrogenesis—Updated 2019
by: Bedair Dewidar, et al.
Published: (2019-11-01)

“The Good, the Bad, and the Ugly” – About Diverse Phenotypes of Hepatic Stellate Cells in the LiverSummary
by: Alexandra Bogomolova, et al.
Published: (2024-01-01)

Fucoxanthin metabolites exert anti-fibrogenic and antioxidant effects in hepatic stellate cells
by: Yang Li, et al.
Published: (2021-12-01)

Modern concepts on pathogenetic mechanisms of liver fibrosis
by: N. A. Efremova, et al.
Published: (2023-04-01)

The Role of Mesothelial Cells in Liver Development, Injury, and Regeneration
Published: (2016-03-01)

Interleukin-19 Gene-Deficient Mice Promote Liver Fibrosis via Enhanced TGF-β Signaling, and the Interleukin-19-CCL2 Axis Is Important in the Direction of Liver Fibrosis
by: Naoshige Ono, et al.
Published: (2023-07-01)

Preclinical Models and Promising Pharmacotherapeutic Strategies in Liver Fibrosis: An Update
by: Tea Omanovic Kolaric, et al.
Published: (2023-05-01)

Extra- and Intra-Cellular Mechanisms of Hepatic Stellate Cell Activation
by: Yufei Yan, et al.
Published: (2021-08-01)

Progress of researches on inducing hepatic stellate cell ferroptosis for treatment of liver fibrosis
by: SUN Lijie, HAO Dandan
Published: (2024-01-01)

Inhibition of Renal Stellate Cell Activation Reduces Renal Fibrosis
by: Jin Joo Cha, et al.
Published: (2020-10-01)

Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives
by: Natascha Roehlen, et al.
Published: (2020-04-01)

Genetic Characterization of Rat Hepatic Stellate Cell Line PAV-1
by: Kiara Gäberlein, et al.
Published: (2023-06-01)

Genetic Characterization of Rat Hepatic Stellate Cell Line HSC-T6 for In Vitro Cell Line Authentication
by: Indrajit Nanda, et al.
Published: (2022-05-01)

Rat Hepatic Stellate Cell Line CFSC-2G: Genetic Markers and Short Tandem Repeat Profile Useful for Cell Line Authentication
by: Indrajit Nanda, et al.
Published: (2022-09-01)

Liver Fibrosis Leading to Cirrhosis: Basic Mechanisms and Clinical Perspectives
by: Kaumudi Somnay, et al.
Published: (2024-09-01)

Heterogeneity of Hepatic Stellate Cells in Fibrogenesis of the Liver: Insights from Single-Cell Transcriptomic Analysis in Liver Injury
by: Wenjun Zhang, et al.
Published: (2021-08-01)

Leonurine Attenuates CCl4-Induced Hepatic Fibrosis in Mice via the Hippo-YAP Pathway
by: Wang P, et al.
Published: (2025-07-01)

Effect of T lymphocyte on hepatic stellate cell activation in liver fibrosis
by: GONG Xiaoqian, et al.
Published: (2025-04-01)

RANKL inhibits activation of hepatic stellate cells during hepatic fibrosis in mice
by: ZHOU Lijia, et al.
Published: (2023-01-01)

MicroRNAs as critical regulators in liver fibrosis
by: Xiaolin Wang, et al.
Published: (2023-09-01)

Doxofylline ameliorates liver fibrosis by regulating the ferroptosis signaling pathway
by: Lenan Xu, et al.
Published: (2023-03-01)

The different effects of four adenosine receptors in liver fibrosis
by: Lan Yang, et al.
Published: (2024-09-01)

Glycochenodeoxycholate Promotes Liver Fibrosis in Mice with Hepatocellular Cholestasis
by: Simon Hohenester, et al.
Published: (2020-01-01)

Carfilzomib shows therapeutic potential for reduction of liver fibrosis by targeting hepatic stellate cell activation
by: Ayana Fujiwara, et al.
Published: (2024-08-01)

DCDC2 inhibits hepatic stellate cell activation and ameliorates CCl4-induced liver fibrosis by suppressing Wnt/β-catenin signaling
by: Qing-Qing Liu, et al.
Published: (2024-04-01)

ATF3‐mediated transactivation of CXCL14 in HSCs during liver fibrosis
by: Xinmiao Li, et al.
Published: (2024-10-01)

Pharmacotherapy of Liver Fibrosis and Hepatitis: Recent Advances
by: Liangtao Zhao, et al.
Published: (2024-12-01)

Furin inhibits HSCs activation and ameliorates liver fibrosis by regulating PTEN‐L/PINK1/parkin mediated mitophagy in mouse
by: Yan‐Wei Song, et al.
Published: (2025-05-01)

Interplays of liver fibrosis-associated microRNAs: Molecular mechanisms and implications in diagnosis and therapy
by: Hong Li, et al.
Published: (2023-07-01)

MitoQ inhibits hepatic stellate cell activation and liver fibrosis by enhancing PINK1/parkin-mediated mitophagy
by: Dou Shi-Ying, et al.
Published: (2021-11-01)

Novel Inositol 1,4,5-Trisphosphate Receptor Inhibitor Antagonizes Hepatic Stellate Cell Activation: A Potential Drug to Treat Liver Fibrosis
by: Natalia Smith-Cortinez, et al.
Published: (2024-04-01)

Single-Cell Transcriptome Analysis Identified Core Genes and Transcription Factors in Mesenchymal Cell Differentiation during Liver Cirrhosis
by: Xue Dai, et al.
Published: (2024-02-01)

Chikusetsusaponin IVa targeted YAP as an inhibitor to attenuate liver fibrosis and hepatic stellate cell activation
by: Kai Gao, et al.
Published: (2025-03-01)

Phomopsterone B Alleviates Liver Fibrosis through mTOR-Mediated Autophagy and Apoptosis Pathway
by: Mei-Lin Peng, et al.
Published: (2024-01-01)

Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice
by: Yosuke Osawa, et al.
Published: (2015-11-01)

Inhibition of FGFR2 Signaling by Cynaroside Attenuates Liver Fibrosis
by: Qilin Meng, et al.
Published: (2023-04-01)

Microvascular Thrombosis and Liver Fibrosis Progression: Mechanisms and Clinical Applications
by: Carlo Airola, et al.
Published: (2023-06-01)

The Role of Butylidenephthalide in Targeting Microenvironment Contributes to the Ameliorate of Liver Fibrosis
by: Hong-Meng eChuang, et al.
Published: (2016-04-01)