The interplay of SARS-CoV-2 evolution and constraints imposed by the structure and functionality of its proteins.
The unprecedented pace of the sequencing of the SARS-CoV-2 virus genomes provides us with unique information about the genetic changes in a single pathogen during ongoing pandemic. By the analysis of close to 200,000 genomes we show that the patterns of the SARS-CoV-2 virus mutations along its genom...
| Published in: | PLoS Computational Biology |
|---|---|
| Main Authors: | Lukasz Jaroszewski, Mallika Iyer, Arghavan Alisoltani, Mayya Sedova, Adam Godzik |
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2021-07-01
|
| Online Access: | https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009147&type=printable |
Similar Items
ViralVar: A Web Tool for Multilevel Visualization of SARS-CoV-2 Genomes
by: Arghavan Alisoltani, et al.
Published: (2022-12-01)
by: Arghavan Alisoltani, et al.
Published: (2022-12-01)
US National Institutes of Health Prioritization of SARS-CoV-2 Variants
by: Sam Turner, et al.
Published: (2023-05-01)
by: Sam Turner, et al.
Published: (2023-05-01)
Domain analysis of the tubulin cofactor system: a model for tubulin folding and dimerization
by: Jaroszewski Lukasz, et al.
Published: (2003-10-01)
by: Jaroszewski Lukasz, et al.
Published: (2003-10-01)
Is SARS-CoV-2 facing constraints in its adaptive evolution?
by: Yingguang Liu
Published: (2025-06-01)
by: Yingguang Liu
Published: (2025-06-01)
Intra-Host Evolution of SARS-CoV-2 During Persistent Infection of Pediatric COVID-19 Patients
by: Charlie R. Boyle, et al.
Published: (2025-09-01)
by: Charlie R. Boyle, et al.
Published: (2025-09-01)
Transmission of SARS-CoV-2 in domestic cats imposes a narrow bottleneck.
by: Katarina M Braun, et al.
Published: (2021-02-01)
by: Katarina M Braun, et al.
Published: (2021-02-01)
The impact of remdesivir on SARS-CoV-2 evolution in vivo
by: Ted Ling-Hu, et al.
Published: (2025-02-01)
by: Ted Ling-Hu, et al.
Published: (2025-02-01)
Bidirectional interplay between SARS-CoV-2 and autophagy
by: Hao Zhou, et al.
Published: (2023-08-01)
by: Hao Zhou, et al.
Published: (2023-08-01)
SARS-CoV-2: An Update on the Biological Interplay with the Human Host
by: Giuseppe Lippi, et al.
Published: (2023-10-01)
by: Giuseppe Lippi, et al.
Published: (2023-10-01)
Modelling the interplay of SARS-CoV-2 variants in the United Kingdom
by: N. L. Barreiro, et al.
Published: (2022-07-01)
by: N. L. Barreiro, et al.
Published: (2022-07-01)
Resurgence of SARS-CoV-2 Delta after Omicron variant superinfection in an immunocompromised pediatric patient
by: Arghavan Alisoltani, et al.
Published: (2023-10-01)
by: Arghavan Alisoltani, et al.
Published: (2023-10-01)
Imposing geometrical constraint in topology optimization for additive manufacturing
by: Takao MIKI, et al.
Published: (2019-05-01)
by: Takao MIKI, et al.
Published: (2019-05-01)
Intra-host SARS-CoV-2 diversity in immunocompromised people living with HIV provides insight into the evolutionary trajectory of SARS-CoV-2
by: R. Joseph, et al.
Published: (2025-10-01)
by: R. Joseph, et al.
Published: (2025-10-01)
Investigating the Interplay of SARS-CoV-2 RNAemia and Peripheral Inflammation in Platelet Dysfunction During Acute SARS-CoV-2 Infection
by: Mariangela Scavone, et al.
Published: (2025-07-01)
by: Mariangela Scavone, et al.
Published: (2025-07-01)
Expansion of the protein repertoire in newly explored environments: human gut microbiome specific protein families.
by: Kyle Ellrott, et al.
Published: (2010-06-01)
by: Kyle Ellrott, et al.
Published: (2010-06-01)
Immunological responses in SARS-CoV-2 and HIV co-infection versus SARS-CoV-2 mono-infection: case report of the interplay between SARS-CoV-2 and HIV
by: Shima Shahbaz, et al.
Published: (2023-10-01)
by: Shima Shahbaz, et al.
Published: (2023-10-01)
Energy Mix Constraints Imposed by Minimum EROI for Societal Sustainability
by: Ziemowit Malecha
Published: (2025-07-01)
by: Ziemowit Malecha
Published: (2025-07-01)
Imposing Star-Shaped Hard Constraints on the Neural Network Output
by: Andrei Konstantinov, et al.
Published: (2024-11-01)
by: Andrei Konstantinov, et al.
Published: (2024-11-01)
Unveiling the interplay between influenza vaccination and SARS-CoV-2 immune responses
by: Jacek Tabarkiewicz, et al.
Published: (2024-05-01)
by: Jacek Tabarkiewicz, et al.
Published: (2024-05-01)
Evaluating the Interplay between Transmissibility and Virulence of SARS-CoV-2 by Mathematical Modeling
by: L. P. Lombardi Jr, et al.
Published: (2023-11-01)
by: L. P. Lombardi Jr, et al.
Published: (2023-11-01)
SARS-CoV-2 and extracellular vesicles: An intricate interplay in pathogenesis, diagnosis and treatment
by: C. Sbarigia, et al.
Published: (2022-08-01)
by: C. Sbarigia, et al.
Published: (2022-08-01)
Product of natural evolution (SARS, MERS, and SARS-CoV-2); deadly diseases, from SARS to SARS-CoV-2
by: Mohamad Hesam Shahrajabian, et al.
Published: (2021-01-01)
by: Mohamad Hesam Shahrajabian, et al.
Published: (2021-01-01)
Interplay of TLR4 and SARS-CoV-2: Possible Involvement of microRNAs [Letter]
by: Gambari R, et al.
Published: (2024-11-01)
by: Gambari R, et al.
Published: (2024-11-01)
SARS-CoV-2 Delta Variant: Interplay between Individual Mutations and Their Allosteric Synergy
by: Kevin C. Chan, et al.
Published: (2022-11-01)
by: Kevin C. Chan, et al.
Published: (2022-11-01)
The interplay between the airway epithelium and tissue macrophages during the SARS-CoV-2 infection
by: Emilia Barreto-Duran, et al.
Published: (2022-10-01)
by: Emilia Barreto-Duran, et al.
Published: (2022-10-01)
Monitoring and assessment of SARS-CoV-2 evolution
by: V. V. Miasoiedov, et al.
Published: (2022-02-01)
by: V. V. Miasoiedov, et al.
Published: (2022-02-01)
Evolution of the SARS-CoV-2 Omicron spike
by: Ruth J. Parsons, et al.
Published: (2023-12-01)
by: Ruth J. Parsons, et al.
Published: (2023-12-01)
Monogamy removes constraints on reproductive tissue investment imposed by intense sexual selection
by: Abril Alexander, et al.
Published: (2025-06-01)
by: Abril Alexander, et al.
Published: (2025-06-01)
Constraints imposed on the creative cover letter writing by digital online job advertisements
by: Debbie Guan Eng Ho, et al.
Published: (2021-12-01)
by: Debbie Guan Eng Ho, et al.
Published: (2021-12-01)
Educational Methods and Technological Innovations for Introductory Experiential Learning Given the Contact-Related Limitations Imposed by the SARS-CoV2/COVID-19 Pandemic
by: Paul M. Reynolds, et al.
Published: (2021-02-01)
by: Paul M. Reynolds, et al.
Published: (2021-02-01)
Global atlas of predicted functional domains in Legionella pneumophila Dot/Icm translocated effectors
by: Deepak T Patel, et al.
Published: (2024-11-01)
by: Deepak T Patel, et al.
Published: (2024-11-01)
SARS-CoV-2 Alchemy: Understanding the dynamics of age, vaccination, and geography in the evolution of SARS-CoV-2 in India.
by: Mansi Patel, et al.
Published: (2025-03-01)
by: Mansi Patel, et al.
Published: (2025-03-01)
Origin, evolution and global spread of SARS-CoV-2
by: Zhukova, Anna, et al.
Published: (2020-11-01)
by: Zhukova, Anna, et al.
Published: (2020-11-01)
Evolution of Antiviral Drug Resistance in SARS-CoV-2
by: Roy Dinata, et al.
Published: (2025-05-01)
by: Roy Dinata, et al.
Published: (2025-05-01)
Unravelling Insights into the Evolution and Management of SARS-CoV-2
by: Aganze Gloire-Aimé Mushebenge, et al.
Published: (2024-02-01)
by: Aganze Gloire-Aimé Mushebenge, et al.
Published: (2024-02-01)
Genomic evolution of the SARS-CoV-2 Variants of Concern
by: Pooja Bhardwaj, et al.
Published: (2023-06-01)
by: Pooja Bhardwaj, et al.
Published: (2023-06-01)
The evolution of SARS-CoV-2 and the COVID-19 pandemic
by: Yuanfang Si, et al.
Published: (2023-09-01)
by: Yuanfang Si, et al.
Published: (2023-09-01)
Mutations and Evolution of the SARS-CoV-2 Spike Protein
by: Nicholas Magazine, et al.
Published: (2022-03-01)
by: Nicholas Magazine, et al.
Published: (2022-03-01)
SARS-CoV-2 genomic characterization and evolution in China
by: Peng Zhang, et al.
Published: (2023-08-01)
by: Peng Zhang, et al.
Published: (2023-08-01)
Understanding the SARS-CoV-2 pandemic as evolution in action
by: Will Cairns
Published: (2020-01-01)
by: Will Cairns
Published: (2020-01-01)
Similar Items
-
ViralVar: A Web Tool for Multilevel Visualization of SARS-CoV-2 Genomes
by: Arghavan Alisoltani, et al.
Published: (2022-12-01) -
US National Institutes of Health Prioritization of SARS-CoV-2 Variants
by: Sam Turner, et al.
Published: (2023-05-01) -
Domain analysis of the tubulin cofactor system: a model for tubulin folding and dimerization
by: Jaroszewski Lukasz, et al.
Published: (2003-10-01) -
Is SARS-CoV-2 facing constraints in its adaptive evolution?
by: Yingguang Liu
Published: (2025-06-01) -
Intra-Host Evolution of SARS-CoV-2 During Persistent Infection of Pediatric COVID-19 Patients
by: Charlie R. Boyle, et al.
Published: (2025-09-01)
