Large-scale production of tauroursodeoxycholic acid products through fermentation optimization of engineered Escherichia coli cell factory

Abstract Background Bear bile powder is a valuable medicinal material characterized by high content of tauroursodeoxycholic acid (TUDCA) at a certain ratio to taurochenodeoxycholic acid (TCDCA). We had created an engineered E. coli harboring two-step bidirectional oxidative and reductive enzyme-cata...

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Bibliographic Details
Published in:	Microbial Cell Factories
Main Authors:	Yingpeng Xu, Li Yang, Shujuan Zhao, Zhengtao Wang
Format:	Article
Language:	English
Published:	BMC 2019-02-01
Subjects:	TUDCA Fermentation Biotransformation Escherichia coli Process optimization Deep-tank static process
Online Access:	http://link.springer.com/article/10.1186/s12934-019-1076-2

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