KLRG1 marks tumor-infiltrating CD4 T cell subsets associated with tumor progression and immunotherapy response
Current methods for biomarker discovery and target identification in immuno-oncology rely on static snapshots of tumor immunity. To thoroughly characterize the temporal nature of antitumor immune responses, we developed a 34-parameter spectral flow cytometry panel and performed high-throughput analy...
| 發表在: | Journal for ImmunoTherapy of Cancer |
|---|---|
| Main Authors: | Charles G Drake, Benjamin Izar, Casey R Ager, Aleksandar Obradovic, Matthew Chaimowitz, Catherine Spina, Mingxuan Zhang, Shruti Bansal, Somnath Tagore, Collin Jugler, Meri Rogava, Johannes C Melms, Patrick McCann, Matthew C Dallos |
| 格式: | Article |
| 語言: | 英语 |
| 出版: |
BMJ Publishing Group
2023-09-01
|
| 在線閱讀: | https://jitc.bmj.com/content/11/9/e006782.full |
相似書籍
572 PYX-102, an anti-KLRG1 antibody, enhances cytotoxic activity of CD8-T-cells from PBMC and human tumor samples by blocking the interaction between KLRG1 and cadherins
由: Ronald Herbst, et al.
出版: (2023-11-01)
由: Ronald Herbst, et al.
出版: (2023-11-01)
329 Longitudinal immune profiling reveals unique myeloid and T cell phenotypes associated with spontaneous immunoediting in a novel prostate tumor model
由: Casey Ager, et al.
出版: (2022-04-01)
由: Casey Ager, et al.
出版: (2022-04-01)
Identification and regulation of circulating tumor-TCR-matched cytotoxic CD4+ lymphocytes by KLRG1 in bladder cancer
由: Serena S. Kwek, et al.
出版: (2025-06-01)
由: Serena S. Kwek, et al.
出版: (2025-06-01)
Expression of KLRG1 and CD127 defines distinct CD8+ subsets that differentially impact patient outcome in follicular lymphoma
由: Hyo Jin Kim, et al.
出版: (2021-07-01)
由: Hyo Jin Kim, et al.
出版: (2021-07-01)
C6 and KLRG2 are pyroptosis subtype-related prognostic biomarkers and correlated with tumor-infiltrating lymphocytes in lung adenocarcinoma
由: Shu-Min Yuan, et al.
出版: (2024-10-01)
由: Shu-Min Yuan, et al.
出版: (2024-10-01)
KLRG1 and CD103 Expressions Define Distinct Intestinal Tissue-Resident Memory CD8 T Cell Subsets Modulated in Crohn's Disease
由: Hugo Bottois, et al.
出版: (2020-05-01)
由: Hugo Bottois, et al.
出版: (2020-05-01)
The Yin and Yang of Targeting KLRG1+ Tregs and Effector Cells
由: Samantha M. Borys, et al.
出版: (2022-04-01)
由: Samantha M. Borys, et al.
出版: (2022-04-01)
The role of KLRG1: a novel biomarker and new therapeutic target
由: Yakun Zhang, et al.
出版: (2024-06-01)
由: Yakun Zhang, et al.
出版: (2024-06-01)
KLRG1 expression induces functional exhaustion of NK cells in colorectal cancer patients
由: Cairui Xu, et al.
出版: (2025-05-01)
由: Cairui Xu, et al.
出版: (2025-05-01)
Characterization of gene expression and biological pathways in Wilms tumor
由: Claire D. Gerall, et al.
出版: (2023-12-01)
由: Claire D. Gerall, et al.
出版: (2023-12-01)
KLRG1-expressing CD8+ T cells are exhausted and polyfunctional in patients with chronic hepatitis B.
由: Li Wang, et al.
出版: (2024-01-01)
由: Li Wang, et al.
出版: (2024-01-01)
Combination blockade of KLRG1 and PD-1 promotes immune control of local and disseminated cancers
由: Angela Tata, et al.
出版: (2021-01-01)
由: Angela Tata, et al.
出版: (2021-01-01)
Alpha-fetoprotein (AFP) as tumor marker in a patient with urothelial cancer with exceptional response to anti-PD-1 therapy and an escape lesion mimic
由: Johannes C. Melms, et al.
出版: (2018-09-01)
由: Johannes C. Melms, et al.
出版: (2018-09-01)
In Vivo Zymosan Treatment Induces IL15-Secreting Macrophages and KLRG1-Expressing NK Cells in Mice
由: Hyun Jung Park, et al.
出版: (2023-07-01)
由: Hyun Jung Park, et al.
出版: (2023-07-01)
Identification of a conserved subset of cold tumors responsive to immune checkpoint blockade
由: Mary Helen Barcellos-Hoff, et al.
出版: (2025-03-01)
由: Mary Helen Barcellos-Hoff, et al.
出版: (2025-03-01)
Expression Characteristics and Prognostic Value of KLRG2 in Endometrial Cancer: A Comprehensive Analysis Based on Multi-Omics Data
由: Xiaoyan Huang, et al.
出版: (2025-06-01)
由: Xiaoyan Huang, et al.
出版: (2025-06-01)
SARS-CoV-2 Spike Protein-Induced Interleukin 6 Signaling Is Blocked by a Plant-Produced Anti-Interleukin 6 Receptor Monoclonal Antibody
由: Collin Jugler, et al.
出版: (2021-11-01)
由: Collin Jugler, et al.
出版: (2021-11-01)
PD-1 blockade potentiates neoadjuvant chemotherapy in NSCLC via increasing CD127+ and KLRG1+ CD8 T cells
由: Zhenzhen Hui, et al.
出版: (2023-05-01)
由: Zhenzhen Hui, et al.
出版: (2023-05-01)
KLRG1 expression identifies short-lived Foxp3+ Treg effector cells with functional plasticity in islets of NOD mice
由: Mara Kornete, et al.
出版: (2017-08-01)
由: Mara Kornete, et al.
出版: (2017-08-01)
Armored and Cold Tumors: A Refractory Subset of Solid Cancer
由: Rui Xu, et al.
出版: (2025-09-01)
由: Rui Xu, et al.
出版: (2025-09-01)
Cytotoxic KLRG1+ IL-7R- effector CD8+ T cells distinguish kidney transplant recipients controlling cytomegalovirus reactivation
由: Yumeng Sun, et al.
出版: (2025-02-01)
由: Yumeng Sun, et al.
出版: (2025-02-01)
Dysregulation of peripheral and intratumoral KLRG1+ CD8+ T cells is associated with immune evasion in patients with non-small-cell lung cancer
由: Juan Zeng, et al.
出版: (2024-07-01)
由: Juan Zeng, et al.
出版: (2024-07-01)
Peripheral T-cell subsets in radiofrequency ablation for tumors from different origins
由: Yinghua Jin, et al.
出版: (2024-03-01)
由: Yinghua Jin, et al.
出版: (2024-03-01)
T cell subsets in cervical cancer tumor microenvironment: advances and therapeutic opportunities
由: Weilin Guo, et al.
出版: (2025-06-01)
由: Weilin Guo, et al.
出版: (2025-06-01)
Characterization of Immune Cell Subsets of Tumor Infiltrating Lymphocytes in Brain Metastases
由: Priyakshi Kalita-de Croft, et al.
出版: (2021-05-01)
由: Priyakshi Kalita-de Croft, et al.
出版: (2021-05-01)
The New T Cell Subset Opens a New Realm for Tumor Immunotherapy
由: Huanjin Zhu, et al.
出版: (2022-11-01)
由: Huanjin Zhu, et al.
出版: (2022-11-01)
Granular Cell Tumor of Rectum: A Very Rare Entity
由: Tagore Sunkara, et al.
出版: (2017-01-01)
由: Tagore Sunkara, et al.
出版: (2017-01-01)
Characterization of innate lymphoid cell subsets infiltrating melanoma and epithelial ovarian tumors
由: Douglas C. Chung, et al.
出版: (2024-12-01)
由: Douglas C. Chung, et al.
出版: (2024-12-01)
Distinct TAM subset with cross-dressing capability determines the bifurcation of tumor immunity
由: Kanako Shimizu, et al.
出版: (2025-06-01)
由: Kanako Shimizu, et al.
出版: (2025-06-01)
IFNγ mediates the resistance of tumor cells to distinct NK cell subsets
由: Adelheid Cerwenka, et al.
出版: (2024-07-01)
由: Adelheid Cerwenka, et al.
出版: (2024-07-01)
Unsupervised clustering reveals noncanonical myeloid cell subsets in the brain tumor microenvironment
由: Ismaïl Hermelo, et al.
出版: (2025-01-01)
由: Ismaïl Hermelo, et al.
出版: (2025-01-01)
Adaptive Subsets Limit the Anti-Tumoral NK-Cell Activity in Hepatocellular Carcinoma
由: Charlotte Rennert, et al.
出版: (2021-06-01)
由: Charlotte Rennert, et al.
出版: (2021-06-01)
Different subsets of tumor infiltrating lymphocytes correlate with NPC progression in different ways
由: Mo Hao-Yuan, et al.
出版: (2010-01-01)
由: Mo Hao-Yuan, et al.
出版: (2010-01-01)
Immunoregulatory Monocyte Subset Promotes Metastasis Associated With Therapeutic Intervention for Primary Tumor
由: Takumi Shibuya, et al.
出版: (2021-06-01)
由: Takumi Shibuya, et al.
出版: (2021-06-01)
N-cadherin protects oral cancer cells from NK cell killing in the circulation by inducing NK cell functional exhaustion via the KLRG1 receptor
由: Qin Xu, et al.
出版: (2022-09-01)
由: Qin Xu, et al.
出版: (2022-09-01)
Abnormalities in T cell subsets in the circulating immunity and tumor microenvironment in patients with pancreatic ductal adenocarcinoma
由: SU Bingwei, SHEN Baiyong
出版: (2025-03-01)
由: SU Bingwei, SHEN Baiyong
出版: (2025-03-01)
Location matters: spatial dynamics of tumor-infiltrating T cell subsets is prognostic in colon cancer
由: Hehuan Zhu, et al.
出版: (2024-02-01)
由: Hehuan Zhu, et al.
出版: (2024-02-01)
AR/ER Ratio Correlates with Expression of Proliferation Markers and with Distinct Subset of Breast Tumors
由: Nelson Rangel, et al.
出版: (2020-04-01)
由: Nelson Rangel, et al.
出版: (2020-04-01)
Odontogenic tumors
由: Nag Shweta, et al.
出版: (2009-01-01)
由: Nag Shweta, et al.
出版: (2009-01-01)
Molecular profiling of pre- and post-treatment pediatric high-grade astrocytomas reveals acquired increased tumor mutation burden in a subset of recurrences
由: Matthew D. Wood, et al.
出版: (2023-09-01)
由: Matthew D. Wood, et al.
出版: (2023-09-01)
相似書籍
-
572 PYX-102, an anti-KLRG1 antibody, enhances cytotoxic activity of CD8-T-cells from PBMC and human tumor samples by blocking the interaction between KLRG1 and cadherins
由: Ronald Herbst, et al.
出版: (2023-11-01) -
329 Longitudinal immune profiling reveals unique myeloid and T cell phenotypes associated with spontaneous immunoediting in a novel prostate tumor model
由: Casey Ager, et al.
出版: (2022-04-01) -
Identification and regulation of circulating tumor-TCR-matched cytotoxic CD4+ lymphocytes by KLRG1 in bladder cancer
由: Serena S. Kwek, et al.
出版: (2025-06-01) -
Expression of KLRG1 and CD127 defines distinct CD8+ subsets that differentially impact patient outcome in follicular lymphoma
由: Hyo Jin Kim, et al.
出版: (2021-07-01) -
C6 and KLRG2 are pyroptosis subtype-related prognostic biomarkers and correlated with tumor-infiltrating lymphocytes in lung adenocarcinoma
由: Shu-Min Yuan, et al.
出版: (2024-10-01)
