Synthesis of Mesoporous Silica and Modified as a Drug Delivery System of Ibuprofen
In this work we synthesized of mesoporous silica nanoparticles and functionalized with 3-aminopropyltriethoxysilane to improve the loading and release of ibuprofen bonded to 3-aminopropyltriethoxysilane. sample were characterized by Fourier transform infrared spectroscopy, Scanning electron microsco...
| 發表在: | Journal of Nanostructures |
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| Main Authors: | , |
| 格式: | Article |
| 語言: | 英语 |
| 出版: |
Nanoscience and Nanotechnology Research Center, University of Kashan
2016-01-01
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| 主題: | |
| 在線閱讀: | http://jns.kashanu.ac.ir/article_13650_1313fb1e35d96c1f9d37b1a7492d762e.pdf |
| 總結: | In this work we synthesized of mesoporous silica nanoparticles and functionalized with 3-aminopropyltriethoxysilane to improve the loading and release of ibuprofen bonded to 3-aminopropyltriethoxysilane. sample were characterized by Fourier transform infrared spectroscopy, Scanning electron microscopy , X-ray diffraction, and ultraviolet-visible. the Fourier transform infrared spectroscopy result demonstrate that organic group were successfully functionalized onto mesoporous silica nanoparticles. Then, we investigate of the adsorption and release of ibuprofen as a drug delivery system in simulated body fluid. The result demonstrates that high adsorption capacity for drug with functionalized sample and slower drug release rate was achieved. |
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| ISSN: | 2251-7871 2251-788X |