Anticancer properties of sulforaphane: current insights at the molecular level

Sulforaphane (SFN) is an isothiocyanate with multiple biomedical applications. Sulforaphane can be extracted from the plants of the genus Brassica. However, broccoli sprouts are the chief source of sulforaphane and are 20 to 50 times richer than mature broccoli as they contain 1,153 mg/100 g. SFN is...

Full description

Bibliographic Details
Published in:	Frontiers in Oncology
Main Authors:	Muhammad Asif Ali, Noohela Khan, Nabeeha Kaleem, Waqas Ahmad, Salem Hussain Alharethi, Bandar Alharbi, Hassan H. Alhassan, Maher M. Al-Enazi, Ahmad Faizal Abdull Razis, Babagana Modu, Daniela Calina, Javad Sharifi-Rad
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-06-01
Subjects:	sulforaphane isothiocyanate anticancer mechanisms cytotoxicity apoptosis
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2023.1168321/full

Similar Items

Oxidative stress, free radicals and antioxidants: potential crosstalk in the pathophysiology of human diseases
by: Priya Chaudhary, et al.
Published: (2023-05-01)

Sulforaphane and Its Bifunctional Analogs: Synthesis and Biological Activity
by: Łukasz Janczewski
Published: (2022-03-01)

Anticancer activity of sulforaphane against human hepatoblastoma cells involves apoptosis, autophagy and inhibition of β-catenin signaling pathway
by: Junshan Lin, et al.
Published: (2020-06-01)

A Lesson Learnt from Food Chemistry—Elevated Temperature Triggers the Antioxidant Action of Two Edible Isothiocyanates: Erucin and Sulforaphane
by: Jakub Cedrowski, et al.
Published: (2020-11-01)

An updated overview of anticancer effects of alternariol and its derivatives: underlying molecular mechanisms
by: Muhammad Torequl Islam, et al.
Published: (2023-03-01)

Exploring the therapeutic and anti-tumor properties of morusin: a review of recent advances
by: Amna Hafeez, et al.
Published: (2023-05-01)

Sulforaphene and sulforaphane in commonly consumed cruciferous plants contributed to antiproliferation in HCT116 colon cancer cells
by: Piman Pocasap, et al.
Published: (2016-02-01)

Contents of sulforaphane and total isothiocyanates, antimutagenic activity, and inhibition of clastogenicity in pulp
by: Jiří Totušek, et al.
Published: (2011-10-01)

Synergistic Interaction between 5-FU and an Analog of Sulforaphane—2-Oxohexyl Isothiocyanate—In an In Vitro Colon Cancer Model
by: Małgorzata Milczarek, et al.
Published: (2021-05-01)

Efficacy and tolerability of sulforaphane in the therapeutic management of cancers: a systematic review of randomized controlled trials
by: Dana ElKhalifa, et al.
Published: (2023-11-01)

An Evaluation of the Anti-Carcinogenic Response of Major Isothiocyanates in Non-Metastatic and Metastatic Melanoma Cells
by: Melina Mitsiogianni, et al.
Published: (2021-02-01)

Apoptotic Potential of Glucomoringin Isothiocyanate (GMG-ITC) Isolated from <i>Moringa oleifera</i> Lam Seeds on Human Prostate Cancer Cells (PC-3)
by: Nurul Ashikin Abd Karim, et al.
Published: (2023-04-01)

Molecular Mechanisms of the Anti-Cancer Effects of Isothiocyanates from Cruciferous Vegetables in Bladder Cancer
by: Tomhiro Mastuo, et al.
Published: (2020-01-01)

Anti-cancer properties of boswellic acids: mechanism of action as anti-cancerous agent
by: Vijay Laxmi Trivedi, et al.
Published: (2023-08-01)

Sulforaphane as a promising anti-caries agents: inhibitory effects on Streptococcus mutans and caries control in a rat model
by: Meijiao Yu, et al.
Published: (2025-01-01)

Phytates as a natural source for health promotion: A critical evaluation of clinical trials
by: Sónia M. G. Pires, et al.
Published: (2023-04-01)

Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms
by: Parteek Prasher, et al.
Published: (2023-04-01)

Induction of Apoptosis by Gluconasturtiin-Isothiocyanate (GNST-ITC) in Human Hepatocarcinoma HepG2 Cells and Human Breast Adenocarcinoma MCF-7 Cells
by: Asvinidevi Arumugam, et al.
Published: (2020-03-01)

Neopeltolide and its synthetic derivatives: a promising new class of anticancer agents
by: Sheila I. Peña-Corona, et al.
Published: (2023-06-01)

Bioavailability, Human Metabolism, and Dietary Interventions of Glucosinolates and Isothiocyanates: Critical Insights and Future Perspectives
by: Federica Narra, et al.
Published: (2025-08-01)

Induction of Apoptosis and Cytotoxicity by Raphasatin in Human Breast Adenocarcinoma MCF-7 Cells
by: Muhammad Din Ibrahim, et al.
Published: (2018-11-01)

Cell Death Effects Induced by Sulforaphane and Allyl Isothiocyanate on P-Glycoprotein Positive and Negative Variants in L1210 Cells
by: Szilvia Kontar, et al.
Published: (2020-04-01)

Beneficial Health Effects of Glucosinolates-Derived Isothiocyanates on Cardiovascular and Neurodegenerative Diseases
by: Ramla Muhammad Kamal, et al.
Published: (2022-01-01)

Anti‐pruritic effect of isothiocyanates: Potential involvement of toll‐like receptor 3 signaling
by: Masaki Moriyama, et al.
Published: (2022-12-01)

Sulforaphane alters the acidification of the yeast vacuole
by: Alexander Wilcox, et al.
Published: (2020-03-01)

Comparative Studies of Extracts Obtained from <i>Brassica oleracea</i> L. Plants at Different Stages of Growth by Isolation and Determination of Isothiocyanates: An Assessment of Chemopreventive Properties of Broccoli
by: Magdalena Ligor, et al.
Published: (2024-01-01)

Myrosinase-dependent and –independent formation and control of isothiocyanate products of glucosinolate hydrolysis.
by: Donato eAngelino, et al.
Published: (2015-10-01)

Sulforaphanes: disruptors of phagophores and autolysosomes
by: Yan Zhou, et al.
Published: (2022-12-01)

Comparison of Pharmacokinetics and Anti-Pulmonary Fibrosis-Related Effects of Sulforaphane and Sulforaphane <i>N</i>-acetylcysteine
by: Eun Suk Son, et al.
Published: (2021-06-01)

Sulforaphane Bioavailability in Healthy Subjects Fed a Single Serving of Fresh Broccoli Microgreens
by: John A. Bouranis, et al.
Published: (2023-10-01)

Sulforaphane from broccoli, an epigenetic modulator in cancer cells
by: Soayébo Dabre, et al.
Published: (2025-10-01)

Sulforaphane’s Multifaceted Potential: From Neuroprotection to Anticancer Action
by: Raymond A. Otoo, et al.
Published: (2023-10-01)

Dietary isothiocyanates and anticancer agents: exploring synergism for improved cancer management
by: Qi Wang, et al.
Published: (2024-06-01)

Evaluating the Anti-Inflammatory and Antioxidant Effects of Broccoli Treated with High Hydrostatic Pressure in Cell Models
by: Yi-Yuan Ke, et al.
Published: (2021-01-01)

Maximization of Sulforaphane Content in Broccoli Sprouts by Blanching
by: Andrea Mahn, et al.
Published: (2022-06-01)

Sulforaphane in experimental hypertension
by: Ali Banigesh, et al.
Published: (2020-07-01)

Factors Influencing Sulforaphane Content in Broccoli Sprouts and Subsequent Sulforaphane Extraction
by: Jan Tříska, et al.
Published: (2021-08-01)

Molecular Pathways Related to Sulforaphane as Adjuvant Treatment: A Nanomedicine Perspective in Breast Cancer
by: María Zenaida Saavedra-Leos, et al.
Published: (2022-10-01)

Sulforaphane as a preventive agent in Oral Cancer- A Systematic Review
by: M. Parasakthi, et al.
Published: (2024-06-01)

Potential of Sulforaphane as a Natural Immune System Enhancer: A Review
by: Andrea Mahn, et al.
Published: (2021-02-01)