Deciphering Antibiotic-Targeted Metabolic Pathways in <i>Acinetobacter baumannii</i>: Insights from Transcriptomics and Genome-Scale Metabolic Modeling

In the ongoing battle against antibiotic-resistant infections, <i>Acinetobacter baumannii</i> has emerged as a critical pathogen in healthcare settings. To understand its response to antibiotic-induced stress, we integrated transcriptomic data from various antibiotics (amikacin sulfate,...

Full description

Bibliographic Details
Published in:	Life
Main Authors:	Fatma Zehra Sarı, Tunahan Çakır
Format:	Article
Language:	English
Published:	MDPI AG 2024-09-01
Subjects:	<i>Acinetobacter baumannii</i> antibiotic resistance metabolic model reporter metabolites
Online Access:	https://www.mdpi.com/2075-1729/14/9/1102

Similar Items

Biofilm-Induced Antibiotic Resistance in Clinical <i>Acinetobacter baumannii</i> Isolates
by: Abebe Mekuria Shenkutie, et al.
Published: (2020-11-01)

<i>Acinetobacter baumannii</i> Resistance: A Real Challenge for Clinicians
by: Rosalino Vázquez-López, et al.
Published: (2020-04-01)

<i>Acinetobacter baumannii</i> Antibiotic Resistance Mechanisms
by: Ioannis Kyriakidis, et al.
Published: (2021-03-01)

Uncovering the Secretion Systems of <i>Acinetobacter baumannii</i>: Structures and Functions in Pathogenicity and Antibiotic Resistance
by: Pu Li, et al.
Published: (2023-01-01)

Genetic Determinants of <i>Acinetobacter baumannii</i> Serum-Associated Adaptive Efflux-Mediated Antibiotic Resistance
by: Mikaeel Young, et al.
Published: (2023-07-01)

CRISPR-Cas in Acinetobacter baumannii Contributes to Antibiotic Susceptibility by Targeting Endogenous AbaI
by: Yuhang Wang, et al.
Published: (2022-08-01)

Prevalence of Carbapenem Resistance Genes among <i>Acinetobacter baumannii</i> Isolated from a Teaching Hospital in Taiwan
by: Pai-Wei Su, et al.
Published: (2023-08-01)

Antibiotic Resistance of Acinetobacter baumannii Strains Isolated in 2015-2018 Years
by: Tuncer Ozekinci, et al.
Published: (2020-08-01)

Alteration in the Morphological and Transcriptomic Profiles of <i>Acinetobacter baumannii</i> after Exposure to Colistin
by: Eun-Jeong Yoon, et al.
Published: (2024-08-01)

Optimization of Pyrazole Compounds as Antibiotic Adjuvants Active against Colistin- and Carbapenem-Resistant <i>Acinetobacter baumannii</i>
by: Filomena Sannio, et al.
Published: (2022-12-01)

A National Surveillance of the Antibiotic Susceptibility of <i>Acinetobacter baumannii</i> in Saudi Arabia
by: Abrar K. Thabit, et al.
Published: (2025-02-01)

Investigating Bacteriophages Targeting the Opportunistic Pathogen <i>Acinetobacter baumannii</i>
by: Kathryn M. Styles, et al.
Published: (2020-04-01)

Regulation of antibiotic persistence and pathogenesis in Acinetobacter baumannii by glutamate and histidine metabolic pathways
by: Ho Seok Sim, et al.
Published: (2025-02-01)

Effect of Subinhibitory Concentrations of Antibiotics and Disinfectants on IS<i>Aba</i>-Mediated Inactivation of Lipooligosaccharide Biosynthesis Genes in <i>Acinetobacter baumannii</i>
by: Héctor Olmeda-López, et al.
Published: (2021-10-01)

Impact of AbaI mutation on virulence, biofilm development, and antibiotic susceptibility in Acinetobacter baumannii
by: Pornpan Pumirat, et al.
Published: (2024-09-01)

Isolation and characterization of Acinetobacter baumannii from environmental waters in Dhaka City, Bangladesh
by: Mohammed Aziz Hossain, et al.
Published: (2025-05-01)

Exploration of Phosphoproteins in <i>Acinetobacter baumannii</i>
by: Lisa Brémard, et al.
Published: (2025-07-01)

Antibiotic Activity of Probiotic Strain Bacillus subtilis 534 Against Clinical Isolates of Acinetobacter baumannii
by: O. V. Efremenkova, et al.
Published: (2020-05-01)

Outer Membrane Vesicles from <i>Acinetobacter baumannii</i>: Biogenesis, Functions, and Vaccine Application
by: Zheqi Weng, et al.
Published: (2023-12-01)

Preclinical Assessment of Bacteriophage Therapy against Experimental <i>Acinetobacter baumannii</i> Lung Infection
by: Sandra-Maria Wienhold, et al.
Published: (2021-12-01)

Quercetin: Synergistic Interaction with Antibiotics against Colistin-Resistant <i>Acinetobacter baumannii</i>
by: Elif Odabaş Köse, et al.
Published: (2023-04-01)

Gallic Acid: A Potent Metabolite Targeting Shikimate Kinase in <i>Acinetobacter baumannii</i>
by: Mansour S. Alturki, et al.
Published: (2024-12-01)

Clinical Implications of Bacteremia Caused by Non-<i>baumannii Acinetobacter</i> Compared with Those of <i>Acinetobacter baumannii</i> Bacteremia
by: Jin Woong Suh, et al.
Published: (2025-09-01)

Comparative Analysis of Clinical Characteristics and Antimicrobial Resistance Between <i>Acinetobacter baumannii</i> and Other <i>Acinetobacter</i> Species
by: Si-Ho Kim, et al.
Published: (2025-01-01)

Antibiotic Resistance and Genotypes of Nosocomial Strains of <i>Acinetobacter baumannii</i> in Kazakhstan
by: Alyona Lavrinenko, et al.
Published: (2021-04-01)

Evaluation of the Synergistic Antibacterial Effects of Fosfomycin in Combination with Selected Antibiotics against Carbapenem–Resistant <i>Acinetobacter baumannii</i>
by: Ozioma F. Nwabor, et al.
Published: (2021-02-01)

The Transcriptomic Signature of Tigecycline in Acinetobacter baumannii
by: Liping Li, et al.
Published: (2020-10-01)

Sequential Hypertonic-Hypotonic Treatment Enhances Efficacy of Antibiotic against <i>Acinetobacter baumannii</i> Biofilm Communities
by: Azeza Falghoush, et al.
Published: (2020-11-01)

Gastrointestinal Colonization of Carbapenem-Resistant <i>Acinetobacter baumannii</i>: What Is the Implication for Infection Control?
by: Shuk-Ching Wong, et al.
Published: (2022-09-01)

Rapid Killing and Biofilm Inhibition of Multidrug-Resistant <i>Acinetobacter baumannii</i> Strains and Other Microbes by Iodoindoles
by: Chaitany Jayprakash Raorane, et al.
Published: (2020-08-01)

Acinetobacter baumannii Efflux Pumps and Antibiotic Resistance
by: Abdi SN, et al.
Published: (2020-02-01)

Hypervirulent <i>Acinetobacter baumannii</i> (hvAB): The Convergence of Virulence and Multidrug Resistance
by: Nan Wu, et al.
Published: (2025-05-01)

Treatment Strategies of Colistin Resistance <i>Acinetobacter baumannii</i> Infections
by: Andria Papazachariou, et al.
Published: (2024-05-01)

Insights into <i>Acinetobacter baumannii</i>: A Review of Microbiological, Virulence, and Resistance Traits in a Threatening Nosocomial Pathogen
by: Carole Ayoub Moubareck, et al.
Published: (2020-03-01)

First Characterization of <i>Acinetobacter baumannii</i>-Specific Filamentous Phages
by: Jelena Narancic, et al.
Published: (2024-05-01)

The Evolution of Antimicrobial Resistance in <i>Acinetobacter baumannii</i> and New Strategies to Fight It
by: Viola Camilla Scoffone, et al.
Published: (2025-01-01)

In Vitro Antibacterial Efficacy of Recombinant Phage-Derived Endolysin LysTAC1 Against Carbapenem-Resistant <i>Acinetobacter baumannii</i>
by: Inam Ullah, et al.
Published: (2025-09-01)

Interaction of <i>Acinetobacter baumannii</i> with Human Serum Albumin: Does the Host Determine the Outcome?
by: Camila Pimentel, et al.
Published: (2021-07-01)

Colistin and Carbapenem-Resistant <i>Acinetobacter baumannii</i> Aci46 in Thailand: Genome Analysis and Antibiotic Resistance Profiling
by: Nalumon Thadtapong, et al.
Published: (2021-08-01)

Prevalence of antibiotic-resistant <i>Acinetobacter baumannii</i> in a 1000-bed tertiary care hospital in Tehran, Iran
by: Rahbar Mohammad, et al.
Published: (2010-04-01)