3D Printing—A “Touch-Button” Approach to Manufacture Microneedles for Transdermal Drug Delivery
Microneedles (MNs) represent the concept of attractive, minimally invasive puncture devices of micron-sized dimensions that penetrate the skin painlessly and thus facilitate the transdermal administration of a wide range of active substances. MNs have been manufactured by a variety of production tec...
| 發表在: | Pharmaceutics |
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| Main Authors: | , , , , , , , , , , |
| 格式: | Article |
| 語言: | 英语 |
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MDPI AG
2021-06-01
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| 主題: | |
| 在線閱讀: | https://www.mdpi.com/1999-4923/13/7/924 |
| _version_ | 1851841758292344832 |
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| author | Merima Sirbubalo Amina Tucak Kenan Muhamedagic Lamija Hindija Ognjenka Rahić Jasmina Hadžiabdić Ahmet Cekic Derzija Begic-Hajdarevic Maida Cohodar Husic Almir Dervišević Edina Vranić |
| author_facet | Merima Sirbubalo Amina Tucak Kenan Muhamedagic Lamija Hindija Ognjenka Rahić Jasmina Hadžiabdić Ahmet Cekic Derzija Begic-Hajdarevic Maida Cohodar Husic Almir Dervišević Edina Vranić |
| author_sort | Merima Sirbubalo |
| collection | DOAJ |
| container_title | Pharmaceutics |
| description | Microneedles (MNs) represent the concept of attractive, minimally invasive puncture devices of micron-sized dimensions that penetrate the skin painlessly and thus facilitate the transdermal administration of a wide range of active substances. MNs have been manufactured by a variety of production technologies, from a range of materials, but most of these manufacturing methods are time-consuming and expensive for screening new designs and making any modifications. Additive manufacturing (AM) has become one of the most revolutionary tools in the pharmaceutical field, with its unique ability to manufacture personalized dosage forms and patient-specific medical devices such as MNs. This review aims to summarize various 3D printing technologies that can produce MNs from digital models in a single step, including a survey on their benefits and drawbacks. In addition, this paper highlights current research in the field of 3D printed MN-assisted transdermal drug delivery systems and analyzes parameters affecting the mechanical properties of 3D printed MNs. The current regulatory framework associated with 3D printed MNs as well as different methods for the analysis and evaluation of 3D printed MN properties are outlined. |
| format | Article |
| id | doaj-art-e9f501651d3e43d5881ddea68cb12bbc |
| institution | Directory of Open Access Journals |
| issn | 1999-4923 |
| language | English |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| spelling | doaj-art-e9f501651d3e43d5881ddea68cb12bbc2025-08-19T22:28:08ZengMDPI AGPharmaceutics1999-49232021-06-0113792410.3390/pharmaceutics130709243D Printing—A “Touch-Button” Approach to Manufacture Microneedles for Transdermal Drug DeliveryMerima Sirbubalo0Amina Tucak1Kenan Muhamedagic2Lamija Hindija3Ognjenka Rahić4Jasmina Hadžiabdić5Ahmet Cekic6Derzija Begic-Hajdarevic7Maida Cohodar Husic8Almir Dervišević9Edina Vranić10Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and HerzegovinaDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and HerzegovinaDepartment of Mechanical Production Engineering, Faculty of Mechanical Engineering, University of Sarajevo, Vilsonovo Setaliste 9, 71000 Sarajevo, Bosnia and HerzegovinaDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and HerzegovinaDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and HerzegovinaDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and HerzegovinaDepartment of Mechanical Production Engineering, Faculty of Mechanical Engineering, University of Sarajevo, Vilsonovo Setaliste 9, 71000 Sarajevo, Bosnia and HerzegovinaDepartment of Mechanical Production Engineering, Faculty of Mechanical Engineering, University of Sarajevo, Vilsonovo Setaliste 9, 71000 Sarajevo, Bosnia and HerzegovinaDepartment of Mechanical Production Engineering, Faculty of Mechanical Engineering, University of Sarajevo, Vilsonovo Setaliste 9, 71000 Sarajevo, Bosnia and HerzegovinaHead and Neck Surgery, Clinical Center University of Sarajevo, Bolnička 25, 71000 Sarajevo, Bosnia and HerzegovinaDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and HerzegovinaMicroneedles (MNs) represent the concept of attractive, minimally invasive puncture devices of micron-sized dimensions that penetrate the skin painlessly and thus facilitate the transdermal administration of a wide range of active substances. MNs have been manufactured by a variety of production technologies, from a range of materials, but most of these manufacturing methods are time-consuming and expensive for screening new designs and making any modifications. Additive manufacturing (AM) has become one of the most revolutionary tools in the pharmaceutical field, with its unique ability to manufacture personalized dosage forms and patient-specific medical devices such as MNs. This review aims to summarize various 3D printing technologies that can produce MNs from digital models in a single step, including a survey on their benefits and drawbacks. In addition, this paper highlights current research in the field of 3D printed MN-assisted transdermal drug delivery systems and analyzes parameters affecting the mechanical properties of 3D printed MNs. The current regulatory framework associated with 3D printed MNs as well as different methods for the analysis and evaluation of 3D printed MN properties are outlined.https://www.mdpi.com/1999-4923/13/7/924microneedles3D printingtransdermal drug deliveryprinting materialsprinting parameters |
| spellingShingle | Merima Sirbubalo Amina Tucak Kenan Muhamedagic Lamija Hindija Ognjenka Rahić Jasmina Hadžiabdić Ahmet Cekic Derzija Begic-Hajdarevic Maida Cohodar Husic Almir Dervišević Edina Vranić 3D Printing—A “Touch-Button” Approach to Manufacture Microneedles for Transdermal Drug Delivery microneedles 3D printing transdermal drug delivery printing materials printing parameters |
| title | 3D Printing—A “Touch-Button” Approach to Manufacture Microneedles for Transdermal Drug Delivery |
| title_full | 3D Printing—A “Touch-Button” Approach to Manufacture Microneedles for Transdermal Drug Delivery |
| title_fullStr | 3D Printing—A “Touch-Button” Approach to Manufacture Microneedles for Transdermal Drug Delivery |
| title_full_unstemmed | 3D Printing—A “Touch-Button” Approach to Manufacture Microneedles for Transdermal Drug Delivery |
| title_short | 3D Printing—A “Touch-Button” Approach to Manufacture Microneedles for Transdermal Drug Delivery |
| title_sort | 3d printing a touch button approach to manufacture microneedles for transdermal drug delivery |
| topic | microneedles 3D printing transdermal drug delivery printing materials printing parameters |
| url | https://www.mdpi.com/1999-4923/13/7/924 |
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