Covalent DNA Binding Is Essential for Gram-Negative Antibacterial Activity of Broad Spectrum Pyrrolobenzodiazepines

It is urgent to find new antibiotic classes against multidrug-resistant bacteria as the rate of discovery of new classes of antibiotics has been very slow in the last 50 years. Recently, pyrrolobenzodiazepines (PBDs) with a C8-linked aliphatic-heterocycle have been identified as a new broad-spectrum...

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Bibliographic Details
Published in:	Antibiotics
Main Authors:	Pietro Picconi, Charlotte K. Hind, J. Mark Sutton, Khondaker Miraz Rahman
Format:	Article
Language:	English
Published:	MDPI AG 2022-12-01
Subjects:	antimicrobial resistance broad-spectrum antibiotics antibacterial drug discovery gram-negative bacteria pyrrolobenzodiazepines
Online Access:	https://www.mdpi.com/2079-6382/11/12/1770

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