Oxytocin levels in children with childhood-onset fluency disorder

• Published in: The Turkish Journal of Pediatrics
• Main Authors: Erdoğan Özgür, Ercan Saruhan, Börte Gürbüz Özgür
• Format: Article
• Language: English
• Published: Hacettepe University Institute of Child Health 2025-10-01
• Subjects: stuttering; childhood; oxytocin; speech disorders; fluency disorder
• Online Access: https://turkjpediatr.org/article/view/6132
• ISSN: 0041-4301; 2791-6421

Background. Evidence suggests a role for oxytocin in language development and cognitive functions in humans. However, there is a lack of research investigating the role of oxytocin in childhood-onset fluency disorder (stuttering). The aim of this study is to compare blood oxytocin levels between children diagnosed with stuttering and healthy controls. Methods. Nineteen male children diagnosed with stuttering, aged between 6 and 11 years, and 27 typically fluent male children as a control group were included. All participants underwent psychiatric screening using the semi-structured interview The Kiddie Schedule for Affective Disorders and Schizophrenia School-Age Children-Present and Lifetime Version, and an ear, nose, throat examination. Serum oxytocin levels were determined using enzyme-linked immunosorbent assay. Results. The median (Q1-Q3) blood oxytocin levels in the case group were 113.4 (90.19-136.3) pg/mL, while in the control group were 136.7 (105.4-203.7) pg/mL. A statistically significant lower level of oxytocin was observed in the case group compared to the control group (U=162, p=0.03). Conclusions. We speculate a potential role of oxytocin in the etiology of developmental stuttering under the umbrella of neurodevelopmental disorders. The investigation of oxytocin, which plays a role in socialization and speech, in future studies on speech fluency disorders is intriguing in terms of its implications for clinical applications, including treatment.