The Probiotic <i>Streptococcus salivarius</i> M18 Increases Plasma Nitrite but Does Not Alter Blood Pressure: A Pilot Randomised Controlled Trial

Some species of oral bacteria can reduce dietary nitrate to nitrite, which can later be converted to nitric oxide in the nitrate—nitrite—nitic oxide pathway. Increasing nitric oxide availability can reduce blood pressure (BP) and improve exercise performance. <i>Streptococcus salivarius</i&...

Full description

Bibliographic Details
Published in:	Applied Microbiology
Main Authors:	Mia C. Burleigh, Bob T. Rosier, Annabel Simpson, Nicholas Sculthorpe, Fiona Henriquez, Chris Easton
Format:	Article
Language:	English
Published:	MDPI AG 2023-07-01
Subjects:	nitric oxide 1 nitrate 2 nitrite 3 probiotic <i>Streptococcus salivarius</i> M18 blood pressure
Online Access:	https://www.mdpi.com/2673-8007/3/3/54

Similar Items

<i>Streptococcus salivarius</i> Role as a Probiotic in Children’s Health and Disease Prophylaxis—A Systematic Review
by: Flavia Cristina Al-Akel, et al.
Published: (2024-12-01)

<i>Streptococcus salivarius</i> and <i>Ligilactobacillus salivarius</i>: Paragons of Probiotic Potential and Reservoirs of Novel Antimicrobials
by: McKinley D. Williams, et al.
Published: (2025-02-01)

In vitro Interactions between <i>Streptococcus intermedius</i> and <i>Streptococcus salivarius</i> K12 on a Titanium Cylindrical Surface
by: Carla Vacca, et al.
Published: (2020-12-01)

Probiotic <i>Streptococcus salivarius</i> Reduces Symptoms of Denture Stomatitis and Oral Colonization by <i>Candida albicans</i>
by: Claudio Passariello, et al.
Published: (2020-04-01)

BLIS Fingerprinting as a Tool to Investigate the Distribution and Significance of Bacteriocin Production and Immunity in <i>Streptococcus pyogenes</i> and <i>Streptococcus salivarius</i>
by: John R. Tagg, et al.
Published: (2025-05-01)

The effects of nitrate on the oral microbiome: a systematic review investigating prebiotic potential
by: Siobhan P. Moran, et al.
Published: (2024-12-01)

Inhibitory effect of Streptococcus salivarius K12 and M18 on halitosis in vitro
by: Hyun‐Jun Yoo, et al.
Published: (2020-04-01)

The Genomic Characteristics of Potential Probiotics: Two <i>Streptococcus salivarius</i> Isolates from a Healthy Individual in China
by: Mingyue Sun, et al.
Published: (2025-03-01)

COMPARING THE EFFECT OF PROBIOTIC STREPTOCOCCUS SALIVARIUS K12 AND M18 ON THE STREPTOCOCCUS MUTANS COUNT, SALIVARY PH AND BUFFER CAPACITY: A RANDOMIZED DOUBLE BLINDED CLINICAL TRIAL
by: Saravanan Poorni, et al.
Published: (2022-01-01)

Streptococcus salivarius pneumonia-associated pneumomediastinum: a case report and literature review
by: Zhuo Chen, et al.
Published: (2024-11-01)

The Effect of Pimpinella Anisum and Origanum Vulgare Extracts Against Streptococcus Sanguinis, Streptococcus Mutans, and Streptococcus Salivarius
by: Fatemeh Lavaee, et al.
Published: (2022-06-01)

Review of <i>Streptococcus salivarius</i> BLIS K12 in the Prevention and Modulation of Viral Infections
by: John R. Tagg, et al.
Published: (2025-01-01)

Efficacy of <i>Streptococcus salivarius</i> Blis K12 in the Prevention of Upper Respiratory Tract Infections in Physically Active Individuals: A Randomized Controlled Trial
by: Alexander Bertuccioli, et al.
Published: (2024-10-01)

A Three-Month Probiotic (the <i>Streptococcus salivarius</i> M18 Strain) Supplementation Decreases Gingival Bleeding and Plaque Accumulation: A Randomized Clinical Trial
by: Ksenia Babina, et al.
Published: (2024-07-01)

Specific Synbiotic Sugars Stimulate <i>Streptococcus salivarius</i> BLIS K12 and BLIS M18 Lantibiotic Production to Expand Bacterial Inhibition Range and Potency
by: Liam K. Harold, et al.
Published: (2024-09-01)

Metabolic and Transcriptomic-Based Characterization of <i>Streptococcus salivarius</i> ssp. <i>thermophilus</i> Snew Fermentation in Milk
by: Ye Wang, et al.
Published: (2025-02-01)

A New Frontier in Oral Care: Live <i>Streptococcus salivarius</i> M18 Probiotic Toothpaste
by: Sonali S. Sali, et al.
Published: (2025-01-01)

Probiotics study with Streptococcus salivarius and its ability to produce bacteriocins and adherence to KB cells
by: Vera FANTINATO, et al.
Published: (2019-08-01)

Evaluation of the effects of Streptococcus salivarius M18 and K12 probiotic bacteria on the Streptococcus mutans in saliva: A randomized clinical trial
by: Firoozeh Nilchian, et al.
Published: (2024-07-01)

Indirect Antioxidant Effects of the Nitrite Anion: Focus on Xanthine Oxidase
by: Xena M. Williams, et al.
Published: (2023-04-01)

Clinical Effects of <i>Streptococcus salivarius</i> K12 in Hospitalized COVID-19 Patients: Results of a Preliminary Study
by: Francesco Di Pierro, et al.
Published: (2022-09-01)

Aztreonam intervention recalibrates microbial interactions between Pseudomonas aeruginosa and Streptococcus salivarius
by: Shiyi Gou, et al.
Published: (2025-10-01)

Antimicrobial and Antibiofilm Activity of the Probiotic Strain <i>Streptococcus salivarius</i> K12 against Oral Potential Pathogens
by: Andrea Stašková, et al.
Published: (2021-06-01)

Quantitative aspects of nitric oxide production from nitrate and nitrite
by: Asghar Ghasemi
Published: (2022-02-01)

Early‐onset neonatal sepsis due to Streptococcus salivarius: A case report
by: Sakviseth Bin, et al.
Published: (2023-01-01)

Use of Streptococcus Salivarius K12 in a cohort of PFAPA patients
by: Alessandra Spagnolo, et al.
Published: (2024-07-01)

A comparison of oral microbiome composition between highly trained competitive athletes and untrained controls
by: Annabel Simpson, et al.
Published: (2025-08-01)

<i>Streptococcus salivarius</i> 24SMBc Genome Analysis Reveals New Biosynthetic Gene Clusters Involved in Antimicrobial Effects on <i>Streptococcus pneumoniae</i> and <i>Streptococcus pyogenes</i>
by: Gaia Vertillo Aluisio, et al.
Published: (2022-10-01)

<i>Ligilactobacillus salivarius</i> PS2 Supplementation during Pregnancy and Lactation Prevents Mastitis: A Randomised Controlled Trial
by: Esther Jiménez, et al.
Published: (2021-09-01)

Antimicrobial effect of Streptococcus salivarius outer membrane-coated nanocomplexes against Candida albicans and oral candidiasis
by: Jiajia Ye, et al.
Published: (2023-09-01)

Splenic mycotic aneurysm complicating <em>Streptococcus salivarius</em> mitral valve endocarditis
by: R. W. P. M. R. A. S. Rajapaksha, et al.
Published: (2023-02-01)

Fermentation of Clementine Juice with <i>Lactobacillus salivarius</i> spp. <i>salivarius</i> CECT 4063: Effect of Trehalose Addition and High-Pressure Homogenization on Antioxidant Properties, Mucin Adhesion, and Shelf Life
by: Cristina Gabriela Burca-Busaga, et al.
Published: (2022-11-01)

Caries Inhibition Potential of <italic>Salivarius</italic> M18 Probiotic in High-risk Children
by: Siragam Pavani Lakshmi, et al.
Published: (2022-08-01)

Therapeutic potential of the nitrite-generated NO pathway in vascular dysfunction.
by: Michael eMadigan, et al.
Published: (2013-07-01)

The comparative effect of propolis and chlorhexidine mouthwash on oral nitrite-producing bacteria and blood pressure regulation
by: R. Bescos, et al.
Published: (2025-12-01)

The effectiveness of using respiratory probiotic Streptococcus salivarius K12 in children with recurrent tonsillitis
by: S.I. Ilchenko, et al.
Published: (2020-03-01)

Exploration of the primary antibiofilm substance and mechanism employed by Lactobacillus salivarius ATCC 11741 to inhibit biofilm of Streptococcus mutans
by: Nan Ma, et al.
Published: (2025-03-01)

Effect of a bacteriocin-producing Streptococcus salivarius on the pathogen Fusobacterium nucleatum in a model of the human distal colon
by: Garreth W. Lawrence, et al.
Published: (2022-12-01)

<i>Ligilactobacillus salivarius</i> 7247 Strain: Probiotic Properties and Anti-<i>Salmonella</i> Effect with Prebiotics
by: Vyacheslav M. Abramov, et al.
Published: (2023-10-01)

Streptococcus salivarius-derived ilexgenin A alleviates pneumonia through the gut-lung axis
by: Xintao Huang, et al.
Published: (2025-08-01)