Rate of action of schistosomicides in mice infected with Schistosoma mansoni
Mice infected with adult Schistosoma mansoni were dosed with a single oral dose of 125 or 250 mg/kg oltipraz, 50 or 100 mg/kg oxamniquine, or 200 or 400 mg/kg praziquantel. The mortality rate of worms and oogram changes were determined between 1 and 16 weeks after dosing. The time required between d...
| Published in: | Revista da Sociedade Brasileira de Medicina Tropical |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Medicina Tropical (SBMT)
1989-12-01
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| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821989000400004&lng=en&tlng=en |
| _version_ | 1857066724799545344 |
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| author | Naftale Katz Emmanuel Pinto Dias Cecilia Pereira de Souza John I. Bruce Gerald C. Coles |
| author_facet | Naftale Katz Emmanuel Pinto Dias Cecilia Pereira de Souza John I. Bruce Gerald C. Coles |
| author_sort | Naftale Katz |
| collection | DOAJ |
| container_title | Revista da Sociedade Brasileira de Medicina Tropical |
| description | Mice infected with adult Schistosoma mansoni were dosed with a single oral dose of 125 or 250 mg/kg oltipraz, 50 or 100 mg/kg oxamniquine, or 200 or 400 mg/kg praziquantel. The mortality rate of worms and oogram changes were determined between 1 and 16 weeks after dosing. The time required between dosing and postmortem to obtain maximum effectiveness was 1 week for praziquantel, 2 weeks for oxamniquine and 8 weeks for oltipraz. Changes in oograms persisted throughout most of the experiment, although relapse has been observed at the 4th week on. |
| format | Article |
| id | doaj-art-eab1eec7b3564862a72ddda1dfc62bca |
| institution | Directory of Open Access Journals |
| issn | 1678-9849 |
| language | English |
| publishDate | 1989-12-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| spelling | doaj-art-eab1eec7b3564862a72ddda1dfc62bca2025-08-19T19:27:05ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98491989-12-0122418318610.1590/S0037-86821989000400004S0037-86821989000400004Rate of action of schistosomicides in mice infected with Schistosoma mansoniNaftale Katz0Emmanuel Pinto Dias1Cecilia Pereira de Souza2John I. Bruce3Gerald C. Coles4Fundação Oswaldo CruzFundação Oswaldo CruzFundação Oswaldo CruzUniversity of LowellUniversity of MassachusettsMice infected with adult Schistosoma mansoni were dosed with a single oral dose of 125 or 250 mg/kg oltipraz, 50 or 100 mg/kg oxamniquine, or 200 or 400 mg/kg praziquantel. The mortality rate of worms and oogram changes were determined between 1 and 16 weeks after dosing. The time required between dosing and postmortem to obtain maximum effectiveness was 1 week for praziquantel, 2 weeks for oxamniquine and 8 weeks for oltipraz. Changes in oograms persisted throughout most of the experiment, although relapse has been observed at the 4th week on.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821989000400004&lng=en&tlng=enSchistosoma mansoniEsquissomicidasMortalidade de vermes |
| spellingShingle | Naftale Katz Emmanuel Pinto Dias Cecilia Pereira de Souza John I. Bruce Gerald C. Coles Rate of action of schistosomicides in mice infected with Schistosoma mansoni Schistosoma mansoni Esquissomicidas Mortalidade de vermes |
| title | Rate of action of schistosomicides in mice infected with Schistosoma mansoni |
| title_full | Rate of action of schistosomicides in mice infected with Schistosoma mansoni |
| title_fullStr | Rate of action of schistosomicides in mice infected with Schistosoma mansoni |
| title_full_unstemmed | Rate of action of schistosomicides in mice infected with Schistosoma mansoni |
| title_short | Rate of action of schistosomicides in mice infected with Schistosoma mansoni |
| title_sort | rate of action of schistosomicides in mice infected with schistosoma mansoni |
| topic | Schistosoma mansoni Esquissomicidas Mortalidade de vermes |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821989000400004&lng=en&tlng=en |
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