The dual role of neutrophils in sepsis-associated liver injury
Sepsis is often accompanied by liver injury and is associated with an increase in the number of circulating and hepatic neutrophils. In sepsis-associated liver injury, neutrophils exhibit phenotypic heterogeneity and perform both pro- and anti-inflammatory functions. Moreover, neutrophil dysfunction...
| Published in: | Frontiers in Immunology |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
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| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1538282/full |
| _version_ | 1849516559497691136 |
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| author | Lexin Fang Yu Song Jiangtao Chen Yueping Ding |
| author_facet | Lexin Fang Yu Song Jiangtao Chen Yueping Ding |
| author_sort | Lexin Fang |
| collection | DOAJ |
| container_title | Frontiers in Immunology |
| description | Sepsis is often accompanied by liver injury and is associated with an increase in the number of circulating and hepatic neutrophils. In sepsis-associated liver injury, neutrophils exhibit phenotypic heterogeneity and perform both pro- and anti-inflammatory functions. Moreover, neutrophil dysfunction and neutrophil-associated immunosuppression are also involved in the pathogenesis of sepsis. Given the complex functionality of this cell type, the aim of this review was to describe the possible mechanistic role of neutrophils in sepsis-associated liver injury, with a brief introduction to neutrophil recruitment and subsequent discussion of the potential contributions of neutrophils to different subtypes of sepsis-associated liver injury. |
| format | Article |
| id | doaj-art-eab3f4558c7b4e8e8ff3e0cc5cd5fb1b |
| institution | Directory of Open Access Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| spelling | doaj-art-eab3f4558c7b4e8e8ff3e0cc5cd5fb1b2025-08-20T02:55:06ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-02-011610.3389/fimmu.2025.15382821538282The dual role of neutrophils in sepsis-associated liver injuryLexin Fang0Yu Song1Jiangtao Chen2Yueping Ding3Department of Intensive Care Unit, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Xinhua Hospital of Zhejiang Province, Hangzhou, Zhejiang, ChinaDepartment of Hepatology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Xinhua Hospital of Zhejiang Province, Hangzhou, Zhejiang, ChinaDepartment of Intensive Care Unit, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Xinhua Hospital of Zhejiang Province, Hangzhou, Zhejiang, ChinaDepartment of Intensive Care Unit, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Xinhua Hospital of Zhejiang Province, Hangzhou, Zhejiang, ChinaSepsis is often accompanied by liver injury and is associated with an increase in the number of circulating and hepatic neutrophils. In sepsis-associated liver injury, neutrophils exhibit phenotypic heterogeneity and perform both pro- and anti-inflammatory functions. Moreover, neutrophil dysfunction and neutrophil-associated immunosuppression are also involved in the pathogenesis of sepsis. Given the complex functionality of this cell type, the aim of this review was to describe the possible mechanistic role of neutrophils in sepsis-associated liver injury, with a brief introduction to neutrophil recruitment and subsequent discussion of the potential contributions of neutrophils to different subtypes of sepsis-associated liver injury.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1538282/fullimmunosuppressioninflammationliver injuryneutrophilsepsis |
| spellingShingle | Lexin Fang Yu Song Jiangtao Chen Yueping Ding The dual role of neutrophils in sepsis-associated liver injury immunosuppression inflammation liver injury neutrophil sepsis |
| title | The dual role of neutrophils in sepsis-associated liver injury |
| title_full | The dual role of neutrophils in sepsis-associated liver injury |
| title_fullStr | The dual role of neutrophils in sepsis-associated liver injury |
| title_full_unstemmed | The dual role of neutrophils in sepsis-associated liver injury |
| title_short | The dual role of neutrophils in sepsis-associated liver injury |
| title_sort | dual role of neutrophils in sepsis associated liver injury |
| topic | immunosuppression inflammation liver injury neutrophil sepsis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1538282/full |
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