iPSC-derived NK cells engineered with CD226 effectively control acute myeloid leukemia

Abstract CD226 plays a vital role in NK cell cytotoxicity, interacting with its ligands on tumor targets. Acute myeloid leukemia (AML) cells have developed mechanisms to escape NK cell cytotoxicity, including inducing downregulation of CD226 on NK cells. Induced pluripotent stem cell -derived NK (iP...

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Bibliographic Details
Published in:	Experimental Hematology & Oncology
Main Authors:	Runze Cai, Binyan Lu, Xiangyu Zhao, Shixin Zhou, Yang Li
Format:	Article
Language:	English
Published:	BMC 2025-07-01
Subjects:	Acute myeloid leukemia iPSC-derived NK cells CD226 Immunotherapy
Online Access:	https://doi.org/10.1186/s40164-025-00686-9

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