Design and biological evaluation of substituted 5,7-dihydro-6H-indolo[2,3-c]quinolin-6-one as novel selective Haspin inhibitors

A library of substituted indolo[2,3-c]quinolone-6-ones was developed as simplified Lamellarin isosters. Synthesis was achieved from indole after a four-step pathway sequence involving iodination, a Suzuki-Miyaura cross-coupling reaction, and a reduction/lactamization sequence. The inhibitory activit...

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Bibliographic Details
Published in:	Journal of Enzyme Inhibition and Medicinal Chemistry
Main Authors:	Sreenivas Avula, Xudan Peng, Xingfen Lang, Micky Tortorella, Béatrice Josselin, Stéphane Bach, Stephane Bourg, Pascal Bonnet, Frédéric Buron, Sandrine Ruchaud, Sylvain Routier, Cleopatra Neagoie
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2022-12-01
Subjects:	Indoloquinoline Haspin kinase docking cell viability
Online Access:	https://www.tandfonline.com/doi/10.1080/14756366.2022.2082419

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