Uncovering mechanism of hepatotoxicity diseases caused by tetrahydrocannabinol based on novel network toxicology and experimental verification

Abstract This study systematically investigated the molecular mechanisms underlying tetrahydrocannabinol (THC)-induced hepatotoxicity in humans through an integrated approach combining network toxicology, molecular docking, and experimental validation. Our analysis identified 22 core targets associa...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:	Scientific Reports
المؤلفون الرئيسيون:	Tiantian Zou, Ruilin Zhang, Liping Hu, Genmeng Yang, Xuanyu Chen, Mengqing Wang, Tiantian Cheng, Shengjie Nie, Linlin Liu, Shijun Hong
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Nature Portfolio 2025-04-01
الموضوعات:	Tetrahydrocannabinol Hepatotoxicity Network toxicology Molecular docking Therapeutic targets
الوصول للمادة أونلاين:	https://doi.org/10.1038/s41598-025-97523-0

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