Study of Crocin (Saffron Component) on Apoptosis or Survival of MCF7 Breast Cancer Cells Lines) PTEN/AKT1 signaling pathway)

Introduction: Evidence shows that secondary metabolites of saffron can be used in the formulation of new drugs for the treatment of various human cancers. It is demonstrated that saffron crocin inhibits the proliferation of cancer cells while having no inhibition effect on the growth of normal cells...

Full description

Bibliographic Details
Published in:	Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām
Main Authors:	Saeid Ghorbian, Aysan Hajizadeh
Format:	Article
Language:	Persian
Published:	Ilam University of Medical Sciences 2022-10-01
Subjects:	apoptosis breast cancer crocin mcf7
Online Access:	http://sjimu.medilam.ac.ir/article-1-7319-en.html

Similar Items

Preventive Effects of Crocin, a Key Carotenoid Component in Saffron, Against Nicotine-Triggered Neurodegeneration in Rat Hippocampus: Possible Role of Autophagy and Apoptosis
by: Mina Gholami, et al.
Published: (2024-09-01)

Octreotide acetate enhanced radio sensitivity and induced apoptosis in MCF7 breast cancer cell line
by: Alkhansa Salih Mahmoud, et al.
Published: (2022-03-01)

Cytotoxic activity and apoptosis induction of Avocado (Persea americana) seed extract on MCF-7 cancer cell line
by: Yuli Widiyastuti, et al.
Published: (2018-12-01)

Regorafenib Suppresses Migration of and Induces Cell Cycle Arrest and Apoptosis in MCF-7 Cells
by: Dawei Wang, et al.
Published: (2021-10-01)

Quantitative Estimation of Saffron Components by Using HPLC an Approach for The Determination of Saffron Quality
by: Sarkar Apurba Kumar
Published: (2025-08-01)

Effect of bispecific recombinant oncolytic adenovirus carrying apoptin on apoptosis of MCF-7 cells
by: Shuang Chen, et al.
Published: (2025-05-01)

Mitochondrial and caspase pathways are involved in the induction of apoptosis by nardosinen in MCF-7 breast cancer cell line
by: Amirhosein Shahali, et al.
Published: (2018-01-01)

Effects of crocin and safranal, saffron constituents, on the formalin-induced orofacial pain in rats
by: Amir Erfanparast, et al.
Published: (2015-08-01)

Dual PI3K/Akt Inhibitors Bearing Coumarin-Thiazolidine Pharmacophores as Potential Apoptosis Inducers in MCF-7 Cells
by: Rana M. Abdelnaby, et al.
Published: (2022-03-01)

Anti-Depressant Properties of Crocin Molecules in Saffron
by: Shahida Anusha Siddiqui, et al.
Published: (2022-03-01)

The efficacy of crocin of saffron (Crocus sativus L.) on the components of metabolic syndrome: A randomized controlled clinical trial
by: Tayyebe Kermani, et al.
Published: (2017-01-01)

Antiproliferative Phenothiazine Hybrids as Novel Apoptosis Inducers against MCF-7 Breast Cancer
by: Jun-Xia Zhang, et al.
Published: (2018-05-01)

Anti-obesity and anorectic effects of saffron and its constituent crocin in obese Wistar rat
by: Saeed Kianbakht, et al.
Published: (2015-03-01)

Bacaba (Oenocarpus bacaba) phenolic extract induces apoptosis in the MCF-7 breast cancer cell line via the mitochondria-dependent pathway
by: Fernanda Dias Bartolomeu Abadio Finco, et al.
Published: (2016-12-01)

The Role of Harmine in Up-regulating p53 Gene Expression and Inducing Apoptosis in MCF-7 Cell Line
by: Shiva Roshankhah, et al.
Published: (2020-01-01)

The Role of Milk Thistle Extract in Breast Carcinoma Cell Line (MCF-7) Apoptosis with Doxorubicin
by: Hussein Rastegar, et al.
Published: (2013-09-01)

A Bottom-Up Synthesis Approach to Silver Nanoparticles Induces Anti-Proliferative and Apoptotic Activities Against MCF-7, MCF-7/TAMR-1 and MCF-10A Human Breast Cell Lines
by: Nurul Izzati Zulkifli, et al.
Published: (2020-09-01)

Effects of Sulfur Containing Glycine Imine Derivatives Compounds on Multidrug Resistance Proteins (MRPs) and Apoptosis Mechanism in MCF-7 and DLD-1 Cell Lines
by: Seda MESCİ, et al.
Published: (2022-08-01)

Effect of the Serum Inhibited Gene (Si1) on Autophagy and Apoptosis in MCF-7 Breast Cancer Cells
by: Yu Li, et al.
Published: (2017-04-01)

Impacts of endurance training and crocin supplementation on the apoptotic pathways in rat skeletal muscle following doxorubicin administration
by: Kavous Eydivandi, et al.
Published: (2024-09-01)

Synthesis of Pirano-Based Piranazole-based Compounds to Induce Apoptosis by Reducing the Expression of Anti-Apoptotic Protein B2 Cell Lymphoma Protein in the MCF-7 Human Breast Cancer Cell Category
by: H Shahriyari-Nejad, et al.
Published: (2021-02-01)

Investigating the Effects of Peiminine and Hyperthermia Therapy on the Induction of Apoptosis in MCF-7 Cell Line
by: Ali Miri, et al.
Published: (2023-10-01)

<i>Rubus</i> Capped Zinc Oxide Nanoparticles Induce Apoptosis in MCF-7 Breast Cancer Cells
by: Blassan P. George, et al.
Published: (2022-10-01)

<it>In vitro </it>cytotoxicity of <it>Strobilanthes crispus </it>ethanol extract on hormone dependent human breast adenocarcinoma MCF-7 cell
by: Chong Hueh, et al.
Published: (2012-04-01)

Molecular mechanisms involved in the anticancer activity of crocin and crocetin, two bioactive compounds found in saffron
by: Mohammad Mehdi Haghighat_Lari, et al.
Published: (2024-10-01)

Safety Evaluation of Crocin (a constituent of saffron) Tablets in Healthy Volunteers
by: Amir Houshang Mohamadpour, et al.
Published: (2013-01-01)

Evaluation of Crocin Content and In Vitro Antioxidant and Anti-Glycation Activity of Different Saffron Extracts
by: Simone Ronsisvalle, et al.
Published: (2023-10-01)

The Prophylactic and Therapeutic Effects of Saffron Extract and Crocin on Ethanol Withdrawal Syndrome in Mice
by: Maryam Shoja, et al.
Published: (2018-12-01)

Magnetic nanoparticles sensitize MCF-7 breast cancer cells to doxorubicin-induced apoptosis
by: Aljarrah Khaled, et al.
Published: (2012-04-01)

Antimicrobial and Cytotoxic Effect of Bornetella Nitida Green Algae Isolate on MCF-7 Breast Cancer
by: Hadisaputri YE, et al.
Published: (2024-09-01)

Investigating the effect of cadmium telluride quantum dots coated with Nerium oleander hydroalcoholic extract on apoptosis induction in MCF7 cancer cells
by: Saeid Bazyar Dehkordi, et al.
Published: (2025-07-01)

An In Vitro Study of Saffron Carotenoids: The Effect of Crocin Extracts and Dimethylcrocetin on Cancer Cell Lines
by: Kyriaki Hatziagapiou, et al.
Published: (2022-05-01)

Anti-proliferative and Apoptotic Effect of Tetrahydrobenzo[h]quinoline on MCF-7 Human Breast Cancer Cell
by: Maryam Ghaffari, et al.
Published: (2022-04-01)

Evaluation of the Cytotoxic and Autophagic Effects of Atorvastatin on MCF-7 Breast Cancer Cells
by: Tuğba Alarcon Martinez, et al.
Published: (2018-05-01)

Investigation of Antiproliferative, Apoptotic and Antioxidant Effects of Oleuropein and Vitamin D on Breast Cancer Cell Lines (MCF-7)
by: Murat Arı, et al.
Published: (2018-12-01)

Tamoxifen-Induced Apoptosis of MCF-7 Cells via GPR30/PI3K/MAPKs Interactions: Verification by ODE Modeling and RNA Sequencing
by: Milad Rouhimoghadam, et al.
Published: (2018-07-01)

Efficient purification of CrocinI from saffron stigmas using antisolvent precipitation to implications for food technology
by: Elmira Fotouhi, et al.
Published: (2025-08-01)

Anti-hyperglycemic Effects of Saffron and its Active Constituents, Crocin and Safranal, in Alloxan-Induced Diabetic Rats
by: S Kianbakht, et al.
Published: (2011-09-01)

Apoptosis Induced by 13-S-hydroxyoctadecadienoic acid in the Breast Cancer Cell Lines, MCF-7 and MDA-MB-231
by: Masoumeh Tavakoli-Yaraki, et al.
Published: (2013-04-01)

4,6′-Anhydrooxysporidinone from <i>Fusarium lateritium</i> SSF2 Induces Autophagic and Apoptosis Cell Death in MCF-7 Breast Cancer Cells
by: Dahae Lee, et al.
Published: (2021-06-01)