Trained-immunity and cross-reactivity for protection: insights from the coronavirus disease 2019 and monkeypox emergencies for vaccine development

The emergence and re-emergence of pathogens is a public-health concern, which has become more evident after the coronavirus disease 2019 (COVID-19) pandemic and the monkeypox outbreaks in early 2022. Given that vaccines are the more effective and affordable tools to control infectious diseases, the...

Full description

Bibliographic Details
Published in:	Exploration of Immunology
Main Authors:	Amanda Izeli Portilho, Elizabeth De Gaspari
Format:	Article
Language:	English
Published:	Open Exploration Publishing Inc. 2023-08-01
Subjects:	coronavirus disease 2019 monkeypox trained-immunity cross-immunity adjuvants
Online Access:	https://www.explorationpub.com/Journals/ei/Article/1003102

Similar Items

Monkeypox outbreak in the age of COVID-19: a new global health emergency
by: Rahim Hirani, et al.
Published: (2022-10-01)

Cross-reactive immune responses to monkeypox virus induced by MVA vaccination in mice
by: Feixia Gao, et al.
Published: (2023-06-01)

From pox to protection: understanding Monkeypox pathophysiology and immune resilience
by: Alagammai Ganesan, et al.
Published: (2025-02-01)

Coronavirus Disease 2019 (COVID-19) Crisis: Losing Our Immunity When We Need It the Most
by: Abdelaziz Ghanemi, et al.
Published: (2021-06-01)

Single Dose of Recombinant Chimeric Horsepox Virus (TNX-801) Vaccination Protects Macaques from Lethal Monkeypox Challenge
by: Ryan S. Noyce, et al.
Published: (2023-01-01)

Coronavirus disease 2019 and the gut–lung axis
by: Dan Zhou, et al.
Published: (2021-12-01)

Vaccinia-Virus-Based Vaccines Are Expected to Elicit Highly Cross-Reactive Immunity to the 2022 Monkeypox Virus
by: Syed Faraz Ahmed, et al.
Published: (2022-09-01)

Knowledge of monkeypox and willingness to vaccinate against monkeypox among Chinese college students: A cross-sectional study
by: Linqiong Zhou, et al.
Published: (2025-04-01)

Is meningococcal B vaccination needed in the post-COVID-19 world?
by: Amanda Izeli Portilho, et al.
Published: (2025-08-01)

Evidence-based yoga and ayurveda lifestyle practices for the geriatric population during Coronavirus Disease 2019 pandemic: A narrative
by: Praag Bhardwaj, et al.
Published: (2021-01-01)

RETRACTED ARTICLE: An overview on mRNA-based vaccines to prevent monkeypox infection
by: Mohammad Natami, et al.
Published: (2024-03-01)

Recent Advances in Research and Management of Human Monkeypox Virus: An Emerging Global Health Threat
by: Parveen Kumar, et al.
Published: (2023-04-01)

Comprehensive evaluations of coronavirus disease 2019 survivors regarding immunity, laboratory and computed tomography change
by: Shereen Bahgat, et al.
Published: (2024-04-01)

Plant-derived molecules in monkeypox management: insight and alternative therapeutic strategies
by: Martin Ndayambaje, et al.
Published: (2025-02-01)

Exploring the Characteristics of Monkeypox-Related Genes in Pan-Cancer
by: Yong Liao, et al.
Published: (2022-12-01)

Monkeypox – An emerging pandemic
by: Kunal M. Ajmera, et al.
Published: (2022-01-01)

Annotation of the Extracellular Enveloped Form of Monkeypox Virus for the Design, Screening, Validation, and Simulation of a Chimeric Vaccine Construct
by: Mohammad Asrar Izhari, et al.
Published: (2025-07-01)

Monkeypox Virus Immune Evasion and Eye Manifestation: Beyond Eyelid Implications
by: Francisco D. Lucena-Neto, et al.
Published: (2023-11-01)

Influence of season of birth on symptomatology of coronavirus disease 2019: An observational study based on ayurveda concept of immunity
by: Anubha Chandla, et al.
Published: (2024-01-01)

Thoughts on renaming “Coronavirus disease 2019” to “Coronavirus infectious syndrome 2019”
by: WANG Jiwei, et al.
Published: (2022-08-01)

Coronavirus disease COVID-2019
by: B. K. Romanov
Published: (2020-03-01)

The prospective outcome of the monkeypox outbreak in 2022 and characterization of monkeypox disease immunobiology
by: Muhammad Suhaib Qudus, et al.
Published: (2023-07-01)

Do we need to vaccinate every child against coronavirus disease 2019 in India?
by: Suraj Kapoor
Published: (2022-01-01)

Evaluation of Monkeypox- and Vaccinia virus-neutralizing antibodies in human serum samples after vaccination and natural infection
by: Alessandro Manenti, et al.
Published: (2023-06-01)

Potential Cross-Reactive Immunity to COVID-19 Infection in Individuals With Laboratory-Confirmed MERS-CoV Infection: A National Retrospective Cohort Study From Saudi Arabia
by: Anas A. Khan, et al.
Published: (2021-09-01)

Characterization of interventional clinical trials for monkeypox; systematic review of ClinicalTrials.gov database
by: Nasser M. Alorfi, et al.
Published: (2023-03-01)

Coronavirus Disease 2019 Vaccination Status at a Tertiary Care Hospital of Uttarakhand: A Retrospective Record-Based Study
by: Pallavi Singh, et al.
Published: (2024-06-01)

Corrigendum: The prospective outcome of the Monkeypox outbreak in 2022 and characterization of monkeypox disease immunobiology
by: Muhammad Suhaib Qudus, et al.
Published: (2023-09-01)

Clinical characteristics of monkeypox vaccine injection site reactions: A cohort of seven patients
by: Anthony A. Gaspari
Published: (2024-03-01)

Vaccination against SARS-CoV-2 provides low-level cross-protection against common cold coronaviruses in mouse and non-human primate animal models
by: Maedeh Naghibosadat, et al.
Published: (2025-02-01)

Convalescent plasma therapy in severe coronavirus disease-2019: A narrative review
by: Rasmi Ranjan Sahoo, et al.
Published: (2020-01-01)

Immunogenicity of monkeypox virus surface proteins and cross-reactive antibody responses in vaccinated and infected individuals: implications for vaccine and therapeutic development
by: Jing Liu, et al.
Published: (2025-02-01)

Correlation of clinical, laboratory, ventilation, and outcome parameters in hospitalized Coronavirus Disease 2019-infected patients with computed tomography severity score
by: Mohammed A Ibrahim, et al.
Published: (2023-01-01)

Comparative Evaluation of Immune Responses and Protection of Chitosan Nanoparticles and Oil-Emulsion Adjuvants in Avian Coronavirus Inactivated Vaccines in Chickens
by: Priscila Diniz Lopes, et al.
Published: (2021-12-01)

Management of coronavirus disease 2019 vaccine-induced cutaneous complications: A comprehensive literature review
by: Nouf F Bin Rubaian, et al.
Published: (2023-01-01)

Sculpting multi-epitope vaccine against Monkeypox viral strains using immunoinformatics
by: Zaira Rehman, et al.
Published: (2025-01-01)

Physical activity, immune system and hypertension: reflections and challenges for future pandemics based on learning from coronavirus disease 2019
by: Francisco Pitanga
Published: (2024-04-01)

Monkeypox as a warning to preserve global herd immunities
by: Daniel Miranda, et al.
Published: (2023-12-01)

Evolving Threats: Adaptive Mechanisms of Monkeypox Virus (MPXV) in the 2022 Global Outbreak and Their Implications for Vaccine Strategies
by: Yuanwen Wang, et al.
Published: (2025-08-01)

Monkeypox Virus Neutralizing Antibodies at Six Months from Mpox Infection: Virologic Factors Associated with Poor Immunologic Response
by: Angelo Roberto Raccagni, et al.
Published: (2024-04-01)