TGF-beta receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence

ABSTRACT Human telomerase reverse transcriptase (hTERT) plays a central role in telomere lengthening for continuous cell proliferation, but it remains unclear how extracellular cues regulate telomerase lengthening of telomeres. Here we report that the cytokine bone morphogenetic protein-7 (BMP7) ind...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:	Protein & Cell
المؤلفون الرئيسيون:	Lucy Cassar, Craig Nicholls, Alex R. Pinto, Ruping Chen, Lihui Wang, He Li, Jun-Ping Liu
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Oxford University Press 2016-09-01
الموضوعات:	BMPRII TGFbeta hTERT telomerase telomeres senescence
الوصول للمادة أونلاين:	http://link.springer.com/article/10.1007/s13238-016-0322-1

مواد مشابهة

Effects of hTERT transfection on the telomere and telomerase of Periplaneta americana cells in vitro
حسب: Chenjing Ma, وآخرون
منشور في: (2023-10-01)

The Status of Telomerase Enzyme Activity in Benign and Malignant Gynaecologic Pathologies
حسب: İlhami Gül, وآخرون
منشور في: (2013-09-01)

The hTERTα Splice Variant is a Dominant Negative Inhibitor of Telomerase Activity
حسب: Lorel M. Colgin, وآخرون
منشور في: (2000-09-01)

Ovarian Telomerase and Female Fertility
حسب: Simon Toupance, وآخرون
منشور في: (2021-07-01)

Expression Profile of a γ-Deletion Variant of the Human Telomerase Reverse Transcriptase Gene
حسب: Hisashi Hisatomi, وآخرون
منشور في: (2003-05-01)

Association of hTERT expression, Her2Neu, estrogen receptors, progesterone receptors, with telomere length before and at the end of treatment in breast cancer patients
حسب: Blanca Olivia Murillo-Ortiz, وآخرون
منشور في: (2024-08-01)

Current Insights to Regulation and Role of Telomerase in Human Diseases
حسب: Mert Burak Ozturk, وآخرون
منشور في: (2017-02-01)

Natural Product Library Screens Identify Sanguinarine Chloride as a Potent Inhibitor of Telomerase Expression and Activity
حسب: Siyu Yan, وآخرون
منشور في: (2022-04-01)

Exosomes derived from hTERT-immortalized cells delay cellular senescence of human fibroblasts
حسب: Yang Liu, وآخرون
منشور في: (2024-09-01)

Alternative Splicing of Human Telomerase Reverse Transcriptase (hTERT) and Its Implications in Physiological and Pathological Processes
حسب: Anna A. Plyasova, وآخرون
منشور في: (2021-05-01)

Associations of meditation with telomere dynamics: a case–control study in healthy adults
حسب: Nirodhi Namika Dasanayaka, وآخرون
منشور في: (2023-07-01)

Methylation of the telomerase gene promoter region in umbilical cord blood of patients with gestational diabetes mellitus is associated with decreased telomerase expression levels and shortened telomere length
حسب: Shuhua Liu, وآخرون
منشور في: (2025-03-01)

Managing telomerase and telomere dysfunction in acral melanoma
حسب: Vishnu Sravan Bollu, وآخرون
منشور في: (2025-05-01)

The Role of Natural Flavonoids as Telomerase Inhibitors in Suppressing Cancer Growth
حسب: Neel Parekh, وآخرون
منشور في: (2023-04-01)

Human Telomerase Reverse Transcriptase and Metallothionein 1A Expressions in Relation with Telomere Length in Healthy Individuals
حسب: Parul Gupta, Mohit Mehndiratta, Edelbert Anthonio Almeida, Seema Garg
منشور في: (2024-08-01)

Telomerase as a Target for Therapeutic Cancer Vaccines and Considerations for Optimizing Their Clinical Potential
حسب: Espen Basmo Ellingsen, وآخرون
منشور في: (2021-07-01)

Role of Telomeres Shortening in Atherogenesis: An Overview
حسب: Yegor E. Yegorov, وآخرون
منشور في: (2021-02-01)

Telomerase-based vaccines: a promising frontier in cancer immunotherapy
حسب: Sogand Vahidi, وآخرون
منشور في: (2024-12-01)

Revisiting Telomere Shortening in Cancer
حسب: Keiji Okamoto, وآخرون
منشور في: (2019-01-01)

Properties of a Telomerase-Specific Cre/Lox Switch for Transcriptionally Targeted Cancer Gene Therapy
حسب: Alan E. Bilsland, وآخرون
منشور في: (2005-11-01)

Inhibition of Telomerase Activity by Oleanane Triterpenoid CDDO-Me in Pancreatic Cancer Cells is ROS-Dependent
حسب: Subhash C. Gautam, وآخرون
منشور في: (2013-03-01)

Telomerase Reverse Transcriptase (TERT) is a Therapeutic Target of Oleanane Triterpenoid CDDO-Me in Prostate Cancer
حسب: Subhash C. Gautam, وآخرون
منشور في: (2012-12-01)

Multiple Actions of Telomerase Reverse Transcriptase in Cell Death Regulation
حسب: Anastasia I. Palamarchuk, وآخرون
منشور في: (2023-04-01)

Telomeres and Telomerase in the Control of Stem Cells
حسب: Alexey Yu. Lupatov, وآخرون
منشور في: (2022-09-01)

RETRACTED: Hsp90‐binding immunophilin FKBP51 forms complexes with hTERT enhancing telomerase activity
حسب: Mariana Lagadari, وآخرون
منشور في: (2016-08-01)

TELOMERASE CATALYTIC SUBUNIT mRNA IN LARYNGEAL SQUAMOUS CELL CARCINOMAS
حسب: Boštjan Luzar, وآخرون
منشور في: (2002-12-01)

Gene expression in mice with endothelium-specific telomerase knockout
حسب: Zhanguo Gao, وآخرون
منشور في: (2023-12-01)

Simultaneous quantification of alternatively spliced transcripts in a single droplet digital PCR reaction
حسب: Bing Sun, وآخرون
منشور في: (2014-06-01)

Application of telomere biology and telomerase in mesenchymal stem cells
حسب: Shuili Jing, وآخرون
منشور في: (2022-12-01)

Activation of telomerase activity and telomere elongation of host cells by Theileria annulata infection
حسب: Junlong Liu, وآخرون
منشور في: (2023-02-01)

Telomeres and telomerase in endometrial cancer and hyperplasia
حسب: Anna Pańczyszyn, وآخرون
منشور في: (2024-03-01)

Starting at the end: telomeres and telomerase in arthropods
حسب: Mandrioli Mauro, وآخرون
منشور في: (2012-10-01)

Telomerase activation in small intestinal neuroendocrine tumours is associated with aberrant TERT promoter methylation, but not hot-spot mutations
حسب: Omid Fotouhi, وآخرون
منشور في: (2019-12-01)

How Do Telomere Abnormalities Regulate the Biology of Neuroblastoma?
حسب: Jesmin Akter, وآخرون
منشور في: (2021-07-01)

Connecting the Dots: Telomere Shortening and Rheumatic Diseases
حسب: Fang Han, وآخرون
منشور في: (2024-10-01)

Parental Genetics Communicate with Intrauterine Environment to Reprogram Newborn Telomeres and Immunity
حسب: Sadia Farrukh, وآخرون
منشور في: (2022-11-01)

Optimized for routine: highly sensitive fluorescent Telomeric Repeat Amplification Protocol (f-TRAP)
حسب: Silke Fähnrich, وآخرون
منشور في: (2024-10-01)

Telomere dysfunction in some pediatric congenital and growth-related diseases
حسب: Bo Zheng, وآخرون
منشور في: (2023-04-01)

Telomerase inhibitors - TMPyP4, BIBR 1532 and imetelstat - alter the adhesion potential of breast cancer MCF7 and MDA-MB-231 cells that leads to impaired ability to form spheroids
حسب: Przemysław Kopczyński, وآخرون
منشور في: (2025-12-01)

Spheroid-Derived Cells From Renal Adenocarcinoma Have Low Telomerase Activity and High Stem-Like and Invasive Characteristics
حسب: Leili Saeednejad Zanjani, وآخرون
منشور في: (2019-12-01)