Heterologous Expression of a VioA Variant Activates Cryptic Compounds in a Marine-Derived Brevibacterium Strain

A new 14-membered homodimeric macrodiolide, brevidiolide (3), along with four known aromatic compounds (1, 2, 4 and 5) were obtained by heterologous expression of the recombinant plasmid pWLI823 expressing the G231L variant of VioA in the marine-derived Brevibacterium sp. 7002-073. The structures of...

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Bibliographic Details
Published in:	Marine Drugs
Main Authors:	Xiao Han, Lukuan Hou, Jing Hou, Yongyu Zhang, Huayue Li, Wenli Li
Format:	Article
Language:	English
Published:	MDPI AG 2018-06-01
Subjects:	heterologous expression recombinant Brevibacterium macrodiolide antibacterial
Online Access:	http://www.mdpi.com/1660-3397/16/6/191

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