Effects of Deep versus Moderate Neuromuscular Blockade on Postoperative Acute and Chronic Pain in Laparoscopic Gynecological Surgery

• الحاوية / القاعدة: Journal of Pain Research
• المؤلفون الرئيسيون: Zhao Y, Zhang J, Qian W, Mu H, Tang Q, Zhang P
• التنسيق: مقال
• اللغة: الإنجليزية
• منشور في: Dove Medical Press 2026-05-01
• الموضوعات: Neuromuscular Blockade; Postoperative Pain; Deep Neuromuscular Blockade; Chronic Postsurgical Pain
• الوصول للمادة أونلاين: https://www.dovepress.com/effects-of-deep-versus-moderate-neuromuscular-blockade-on-postoperativ-peer-reviewed-fulltext-article-JPR

Ying Zhao, Jingjing Zhang, Wei Qian, Hailing Mu, Qiushuang Tang, Peng Zhang Department of Anesthesiology, The Second People’s Hospital, Wuhu, Anhui, People’s Republic of ChinaCorrespondence: Peng Zhang, Department of Anesthesiology, The Second People’s Hospital, Wuhu, Anhui, People’s Republic of China, Tel [phone], Email [e-mail]: To evaluate the effects of deep neuromuscular blockade (D-NMB) versus moderate NMB (M-NMB) on postoperative pain and chronic postsurgical pain (CPSP) in patients undergoing laparoscopic gynecological surgery.Patients and Methods: Seventy-two patients scheduled for laparoscopic uterine or adnexal surgery were randomly assigned to Group D (D-NMB, post-tetanic count 1– 2) or Group M (M-NMB, train-of-four count 1– 2). Postoperative pain was assessed using the visual analogue scale (VAS) at multiple time points. Surgeon satisfaction score (SRS), opioid consumption, Quality of Recovery-15 (QoR-15) score, and CPSP incidence at 3 and 6 months were compared.Results: The VAS score at 0.5 hours postoperatively was significantly lower in Group D than in Group M (4.18± 1.40 vs. 5.42± 1.61, P=0.001). Postoperative opioid consumption and the proportion requiring additional analgesia were significantly reduced in Group D (P=0.011 and P=0.019, respectively).SRS and QoR-15 scores were significantly higher in Group D (P< 0.001 and P=0.022, respectively). No significant differences were observed in CPSP incidence or adverse reactions between the two groups.Conclusion: D-NMB improves early postoperative pain control, reduces opioid requirements, and enhances surgeon satisfaction and early recovery quality without increasing adverse events, but does not reduce CPSP incidence.Keywords: neuromuscular blockade, postoperative pain, deep neuromuscular blockade, chronic postsurgical pain