A novel vaccine construct against Zika virus fever: insights from epitope-based vaccine discovery through molecular modeling and immunoinformatics approaches

The Zika virus (ZIKV) is an emerging virus associated with the Flaviviridae family that mainly causes infection in pregnant women and leads to several abnormalities during pregnancy. This virus has unique properties that may lead to pathological diseases. As the virus has the ability to evade immune...

Full description

Bibliographic Details
Published in:	Frontiers in Immunology
Main Authors:	Metab Alharbi, Abdulrahman Alshammari, Jawza F. Alsabhan, Sami I. Alzarea, Talal Alshammari, Fawaz Alasmari, Abdullah F. Alasmari
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-07-01
Subjects:	epitopes base vaccine construct molecular docking molecular dynamic simulation Zika virus binding free energies
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1426496/full

Similar Items

Peptide-Based Subunit Vaccine Design of T- and B-Cells Multi-Epitopes against Zika Virus Using Immunoinformatics Approaches
by: Vivitri Dewi Prasasty, et al.
Published: (2019-07-01)

Revolutionizing the virulent protein Internalin a in Listeria monocytogenes and designing multi epitope-based vaccine via immunoinformatic approaches
by: Tariq Aziz, et al.
Published: (2024-12-01)

Identification of B-cell epitopes of Indian Zika virus strains using immunoinformatics
by: Rohan Raj Roy, et al.
Published: (2025-02-01)

Whole Proteome-Based Therapeutic Targets Annotation and Designing of Multi-Epitope-Based Vaccines against the Gram-Negative XDR-<i>Alcaligenes faecalis</i> Bacterium
by: Metab Alharbi, et al.
Published: (2022-03-01)

Exploring glutathione transferase and Cathepsin L-like proteinase for designing of epitopes-based vaccine against Fasciola hepatica by immunoinformatics and biophysics studies
by: Hassan H. Alhassan, et al.
Published: (2024-09-01)

Immunoinformatics for Novel Multi-Epitope Vaccine Development in Canine Parvovirus Infections
by: Bashudeb Paul, et al.
Published: (2023-08-01)

Design of a multi-epitope vaccine against goatpox virus using an immunoinformatics approach
by: Qinqin Long, et al.
Published: (2024-02-01)

In Silico BCell Epitope Design of Zika Virus Vaccine Using “Zika Virus Isolate Zika Virus/H sapiensTc/Tha/2006/CVD_06020 Complete Genome”
by: Lisa Savitri, et al.
Published: (2023-09-01)

Immunoinformatics and Biophysics Approaches to Design a Novel Multi-Epitopes Vaccine Design against <i>Staphylococcus auricularis</i>
by: Roba Attar, et al.
Published: (2022-04-01)

An immunoinformatics study: designing multivalent T-cell epitope vaccine against canine circovirus
by: Pankaj Jain, et al.
Published: (2021-08-01)

Targeting Yezo Virus Structural Proteins for Multi-Epitope Vaccine Design Using Immunoinformatics Approach
by: Sudais Rahman, et al.
Published: (2024-09-01)

Integrated immunoinformatics and subtractive proteomics approach for multi-epitope vaccine designing to combat S. pneumoniae TIGR4
by: Sami S. Ashgar, et al.
Published: (2023-07-01)

An immunoinformatics-based designed multi-epitope candidate vaccine against Mycoplasma pneumoniae
by: Behzad Shahbazi, et al.
Published: (2025-09-01)

Designing a multi-epitope influenza vaccine: an immunoinformatics approach
by: Leila Momajadi, et al.
Published: (2024-10-01)

A novel mRNA multi-epitope vaccine of Acinetobacter baumannii based on multi-target protein design in immunoinformatic approach
by: Yizhong Xu, et al.
Published: (2024-08-01)

An immunoinformatic investigation on Rift Valley fever virus protein reveals possible epitopes for vaccines
by: Tanjir Hosen, et al.
Published: (2024-07-01)

Immunoinformatics-Aided Analysis of RSV Fusion and Attachment Glycoproteins to Design a Potent Multi-Epitope Vaccine
by: Hamza Arshad Dar, et al.
Published: (2022-08-01)

Immunoinformatics design of a multi-epitope vaccine for Chlamydia trachomatis major outer membrane proteins
by: Seema Shetty, et al.
Published: (2024-12-01)

Identification of B-Cell Epitopes with Potential to Serologicaly Discrimnate Dengue from Zika Infections
by: Alice F. Versiani, et al.
Published: (2019-11-01)

Design of a Novel and Potent Multi-Epitope Chimeric Vaccine against Human Papillomavirus (HPV): An Immunoinformatics Approach
by: Muhammad Shahab, et al.
Published: (2023-05-01)

Design of a multi-epitope vaccine candidate against Helicobacter pylori in gastric cancer: an immunoinformatic approach
by: Shojaeian, Ali, et al.
Published: (2025-06-01)

Development of multi-epitope vaccines against the monkeypox virus based on envelope proteins using immunoinformatics approaches
by: Caixia Tan, et al.
Published: (2023-03-01)

Designing a Multi-Epitope Vaccine against <i>Toxoplasma gondii</i>: An Immunoinformatics Approach
by: Mutiat Hammed-Akanmu, et al.
Published: (2022-08-01)

Development of a Universal Multi-Epitope Vaccine Candidate against <i>Streptococcus suis</i> Infections Using Immunoinformatics Approaches
by: Yumin Zhang, et al.
Published: (2023-05-01)

Immunoinformatics Approach to Design Multi-Epitope-Based Vaccine against Machupo Virus Taking Viral Nucleocapsid as a Potential Candidate
by: Muhammad Naveed, et al.
Published: (2022-10-01)

Multi-epitope-based vaccine designing against Junín virus glycoprotein: immunoinformatics approach
by: Mallari Praveen
Published: (2024-02-01)

Development of a novel multi-epitope vaccine for brucellosis prevention
by: Kaiyu Shang, et al.
Published: (2024-07-01)

Designing a broad-spectrum multi-epitope subunit vaccine against leptospirosis using immunoinformatics and structural approaches
by: Guneswar Sethi, et al.
Published: (2025-01-01)

Designing a multi-epitope vaccine against Pseudomonas aeruginosa via integrating reverse vaccinology with immunoinformatics approaches
by: Fei Zhu, et al.
Published: (2025-03-01)

Identification of immunodominant T cell epitopes induced by natural Zika virus infection
by: Christopher S. Eickhoff, et al.
Published: (2023-08-01)

An Immunoinformatics Approach to Design Novel and Potent Multi-Epitope-Based Vaccine to Target Lumpy Skin Disease
by: Muhammad Shahab, et al.
Published: (2023-01-01)

Design of a multi-epitope vaccine against six Nocardia species based on reverse vaccinology combined with immunoinformatics
by: Fei Zhu, et al.
Published: (2023-02-01)

Secreted Aspartyl Proteinases Targeted Multi-Epitope Vaccine Design for <i>Candida dubliniensis</i> Using Immunoinformatics
by: Nahid Akhtar, et al.
Published: (2023-02-01)

Corrigendum: Structural Influence on the Dominance of Virus-Specific CD4 T Cell Epitopes in Zika Virus Infection
by: Maximilian Koblischke, et al.
Published: (2018-09-01)

An immunoinformatics and structural vaccinology approach to design a novel and potent multi-epitope base vaccine targeting Zika virus
by: Mohammed Ageeli Hakami
Published: (2024-02-01)

Virus-like particle vaccine with authentic quaternary epitopes protects against Zika virus-induced viremia and testicular damage
by: Sandra R. Abbo, et al.
Published: (2025-04-01)

A novel mRNA-based multi-epitope vaccine for rabies virus computationally designed via reverse vaccinology and immunoinformatics
by: Wafa Tombari, et al.
Published: (2025-08-01)

Design of a Multi-Epitopes Vaccine against Hantaviruses: An Immunoinformatics and Molecular Modelling Approach
by: Saba Ismail, et al.
Published: (2022-02-01)

Immunoinformatics and structural aided approach to develop multi-epitope based subunit vaccine against Mycobacterium tuberculosis
by: Guneswar Sethi, et al.
Published: (2024-07-01)

Bioinformatics and immunoinformatics assisted multiepitope vaccine construct against Burkholderia anthina
by: Maha A. Alshiekheid, et al.
Published: (2024-01-01)