Improved Mucoadhesion, Permeation and In Vitro Anticancer Potential of Synthesized Thiolated Acacia and Karaya Gum Combination: A Systematic Study

Thiolation of polymers is one of the most appropriate approaches to impart higher mechanical strength and mucoadhesion. Thiol modification of gum karaya and gum acacia was carried out by esterification with 80% thioglycolic acid. FTIR, DSC and XRD confirmed the completion of thiolation reaction. Ant...

Full description

Bibliographic Details
Published in:	Molecules
Main Authors:	Neha Munot, Ujjwala Kandekar, Chaitali Rikame, Abhinandan Patil, Poulomi Sengupta, Shabana Urooj, Anusha Bilal
Format:	Article
Language:	English
Published:	MDPI AG 2022-10-01
Subjects:	mucoadhesion thiolated gums ivabradine HCl buccal tablets enhanced permeation
Online Access:	https://www.mdpi.com/1420-3049/27/20/6829

Similar Items

Intraoral Drug Delivery: Highly Thiolated κ-Carrageenan as Mucoadhesive Excipient
by: Gergely Kali, et al.
Published: (2023-07-01)

Tobramycin-loaded nanoparticles of thiolated chitosan for ocular drug delivery: Preparation, mucoadhesion and pharmacokinetic evaluation
by: Sadaf Javed, et al.
Published: (2023-09-01)

Synthesis and characterization of thiolated hexanoyl glycol chitosan as a mucoadhesive thermogelling polymer
by: Ik Sung Cho, et al.
Published: (2018-09-01)

Bioadhesiveness of thiolated pectin for buccal delivery of carbenoxolone sodium
by: Kamonrak Cheewatanakornkool, et al.
Published: (2016-02-01)

Formulation Options for Mucoadhesive Dosage Forms for Use in the Oral Cavity
by: Šimunková V., et al.
Published: (2023-09-01)

Buccal administration of mucoadhesive blend films saturated with propranolol loaded nanoparticles
by: Pakorn Kraisit, et al.
Published: (2018-01-01)

Effects of Sucrose Palmitate on the Physico-Chemical and Mucoadhesive Properties of Buccal Films
by: András Kelemen, et al.
Published: (2020-11-01)

Comparative Study of Different Combinational Mucoadhesive Formulations of Sumatriptan-Metoclopramide
by: Mitra Jelvehgari, et al.
Published: (2016-03-01)

Mucoadhesive Gelatin Buccal Films with Propranolol Hydrochloride: Evaluation of Mechanical, Mucoadhesive, and Biopharmaceutical Properties
by: Marija Jovanović, et al.
Published: (2021-02-01)

Design and Evaluation of S-Protected Thiolated-Based Itopride Hydrochloride Polymeric Nanocrystals for Functional Dyspepsia: QbD-Driven Optimization, In Situ, In Vitro, and In Vivo Investigation
by: Moutaz Y. Badr, et al.
Published: (2023-06-01)

Development of an ANN optimized mucoadhesive buccal tablet containing flurbiprofen and lidocaine for dental pain
by: Hussain Amjad, et al.
Published: (2016-06-01)

Synthesis and functionalization of mucoadhesive mesoporous silica particles containing diphenhydramine for treatment of aphthous ulcers
by: Azadeh Vaezi Moghaddam, et al.
Published: (2023-11-01)

Risperidone mucoadhesive buccal tablets: formulation design, optimization and evaluation
by: Çelik B
Published: (2017-11-01)

Investigation of Surface Properties and Free Volumes of Chitosan-Based Buccal Mucoadhesive Drug Delivery Films Containing Ascorbic Acid
by: Katalin Kristó, et al.
Published: (2022-02-01)

Optimization of Thiolated Chitosan Nanoparticles for the Enhancement of in Vivo Hypoglycemic Efficacy of Sitagliptin in Streptozotocin-Induced Diabetic Rats
by: Kousalya Prabahar, et al.
Published: (2020-03-01)

Preparation and Characterization of a Novel Mucoadhesive Carvedilol Nanosponge: A Promising Platform for Buccal Anti-Hypertensive Delivery
by: El-Sayed Khafagy, et al.
Published: (2022-04-01)

Chlorhexidine Mucoadhesive Buccal Tablets: The Impact of Formulation Design on Drug Delivery and Release Kinetics Using Conventional and Novel Dissolution Methods
by: Enas Al-Ani, et al.
Published: (2021-05-01)

Buccal Bullfrog (<i>Rana catesbeiana</i> Shaw) Oil Emulsion: A Mucoadhesive System Intended for Treatment of Oral Candidiasis
by: Susiane S. Moreira-Oliveira, et al.
Published: (2018-12-01)

Preparation of glimepiride mucoadhesive tablets by direct compression method and their in-vitro evaluation
by: Anum Akram, et al.
Published: (2019-07-01)

Concept of Orodispersible or Mucoadhesive “Tandem Films” and Their Pharmaceutical Realization
by: Anja Göbel, et al.
Published: (2022-01-01)

Mucoadhesive Marine Polysaccharides
by: Irina M. Yermak, et al.
Published: (2022-08-01)

Mucoadhesive drug delivery systems
by: Rahamatullah Shaikh, et al.
Published: (2011-01-01)

Formulation and Optimization of Sodium Alginate Polymer Film as a Buccal Mucoadhesive Drug Delivery System Containing Cetirizine Dihydrochloride
by: Krisztián Pamlényi, et al.
Published: (2021-04-01)

Unlocking traditional remedy: Gulkand-enhanced mucoadhesive gel for canker sore relief
by: Manoj Madanahalli Ramesh, et al.
Published: (2024-11-01)

Polycomplex Carrier for Buccal Mucoadhesion Delivery of Metronidazole
by: R. I. Moustafine, et al.
Published: (2020-05-01)

Assessment of Binary Agarose–Carbopol Buccal Gels for Mucoadhesive Drug Delivery: Ex Vivo and In Vivo Characterization
by: Muhammad Ali Syed, et al.
Published: (2022-10-01)

To study the effect of HPMC and Carbopol in mucoadhesive buccal tablets of Meclizine hydrochloride using Central Composite Design: In-vitro Characterization
by: Shardor Ambarish, et al.
Published: (2024-04-01)

Synthesis and Evaluation of Thiol-Conjugated Poloxamer and Its Pharmaceutical Applications
by: Muhammad Zaman, et al.
Published: (2021-05-01)

Mucoadhesive drug delivery system: An overview
by: Bindu M Boddupalli, et al.
Published: (2010-01-01)

S-Thiolation Targets Albumin in Heart Failure
by: Maura Brioschi, et al.
Published: (2020-08-01)

Development and in vitro Evaluation of Cannabidiol Mucoadhesive Buccal Film Formulations Using Hot-Melt Extrusion Technology
by: Iman E. Taha, et al.
Published: (2024-10-01)

Evaluation and Optimization of Prolonged Release Mucoadhesive Tablets of Dexamethasone for Wound Healing: In Vitro–In Vivo Profiling in Healthy Volunteers
by: Qurrat ul Ain Javed, et al.
Published: (2022-04-01)

Buccal Thin Films as Potent Permeation Enhancers for Cytisine Transbuccal Delivery
by: Viviana De Caro, et al.
Published: (2022-11-01)

Buccal Resveratrol Delivery System as a Potential New Concept for the Periodontitis Treatment
by: Magdalena Paczkowska-Walendowska, et al.
Published: (2021-03-01)

Formulation and Evaluation of Prednisolone Sodium Metazoate-Loaded Mucoadhesive Quatsomal Gel for Local Treatment of Recurrent Aphthous Ulcers: Optimization, In Vitro, Ex Vivo, and In Vivo Studies
by: Ashraf Kassem, et al.
Published: (2023-07-01)

Quality by Design-Guided Systematic Development and Optimization of Mucoadhesive Buccal Films
by: Alharith A. A. Hassan, et al.
Published: (2023-09-01)

Mucoadhesive Buccal Films for Local Delivery of <i>Lactobacillus brevis</i>
by: Angela Abruzzo, et al.
Published: (2020-03-01)

Formulation and evaluation of mucoadhesive buccal patch of acyclovir utilizing inclusion phenomenon
by: Ankita Saxena, et al.
Published: (2011-12-01)

Evaluating Novel Agarose-Based Buccal Gels Scaffold: Mucoadhesive and Pharmacokinetic Profiling in Healthy Volunteers
by: Muhammad Ali Syed, et al.
Published: (2022-07-01)

A multilayered nanofibrous mucoadhesive system for chamomile and Lidocaine controlled delivery in aphthous
by: Zeynab Ahmadifard, et al.
Published: (2025-04-01)