Mesenchymal Stem Cell-Derived Exosomal MiRNAs Promote M2 Macrophages Polarization: Therapeutic Opportunities for Spinal Cord Injury

Spinal cord injury (SCI) is an enormous public health concern affecting approximately 250,000–500,000 people worldwide each year. It is mostly irreversible considering the limitations of currently available treatments, and its prevention and management have been the prime focus of many studies. Mese...

Full description

Bibliographic Details
Published in:	Frontiers in Molecular Neuroscience
Main Authors:	Ze-Yan Liang, Xiong-Jie Xu, Jian Rao, Zhe-Lun Yang, Chun-Hua Wang, Chun-Mei Chen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-07-01
Subjects:	spinal cord injury macrophages mesenchymal stem cells exosomes microRNA
Online Access:	https://www.frontiersin.org/articles/10.3389/fnmol.2022.926928/full

Similar Items

Mesenchymal stem cell-derived exosomes: therapeutic opportunities and challenges for spinal cord injury
by: Wen-zhao Liu, et al.
Published: (2021-02-01)

Emerging Exosomes and Exosomal MiRNAs in Spinal Cord Injury
by: Jia Feng, et al.
Published: (2021-07-01)

Potential of different cells-derived exosomal microRNA cargos for treating spinal cord injury
by: Dayu Pan, et al.
Published: (2021-11-01)

Overexpression of miRNA-216 in exosomes derived from umbilical cord mesenchymal stem cells promotes angiogenesis and improves functional recovery after spinal cord injury
by: Hengde Li, et al.
Published: (2025-10-01)

Inhibition of Ferroptosis by Mesenchymal Stem Cell-Derived Exosomes in Acute Spinal Cord Injury: Role of Nrf2/GCH1/BH4 Axis
by: Yixin Chen, et al.
Published: (2024-06-01)

Macrophage polarization in spinal cord injury repair and the possible role of microRNAs: A review
by: Jiawei Wang, et al.
Published: (2023-12-01)

Regenerative Effects of Exosomes-Derived MSCs: An Overview on Spinal Cord Injury Experimental Studies
by: Giovanni Schepici, et al.
Published: (2023-01-01)

Stem Cell-Derived Exosomes as a Therapeutic Option for Spinal Cord Injuries; a Systematic Review and Meta-Analysis
by: Sajjad Jabermoradi, et al.
Published: (2024-09-01)

Mesenchymal stem cell-derived exosomes as a new drug carrier for the treatment of spinal cord injury: A review
by: Lin-Fei Cheng, et al.
Published: (2024-05-01)

Emerging regenerative strategies for spinal cord injury: exosome-derived mechanisms and therapeutic insights
by: Haixia Fan, et al.
Published: (2025-08-01)

Safety and potential effects of intrathecal injection of allogeneic human umbilical cord mesenchymal stem cell-derived exosomes in complete subacute spinal cord injury: a first-in-human, single-arm, open-label, phase I clinical trial
by: Mohammadhosein Akhlaghpasand, et al.
Published: (2024-08-01)

Research landscape and trends of human umbilical cord mesenchymal stem cell-derived exosomes
by: Desheng Chen, et al.
Published: (2025-05-01)

Exosomes derived from human placental mesenchymal stem cells enhanced the recovery of spinal cord injury by activating endogenous neurogenesis
by: Wenshu Zhou, et al.
Published: (2021-03-01)

Human Epidural AD–MSC Exosomes Improve Function Recovery after Spinal Cord Injury in Rats
by: Soo-Eun Sung, et al.
Published: (2022-03-01)

Exosomes secreted from miRNA-29b-modified mesenchymal stem cells repaired spinal cord injury in rats
by: Tao Yu, et al.
Published: (2019-12-01)

Exosomes derived from umbilical cord-mesenchymal stem cells inhibit the NF-κB/MAPK signaling pathway and reduce the inflammatory response to promote recovery from spinal cord injury
by: Zhiwei Luan, et al.
Published: (2024-03-01)

Exosomes Derived From Bone Marrow Mesenchymal Stem Cells Inhibit Complement Activation In Rats With Spinal Cord Injury
by: Zhao C, et al.
Published: (2019-10-01)

MiRNAs as Promising Translational Strategies for Neuronal Repair and Regeneration in Spinal Cord Injury
by: Serena Silvestro, et al.
Published: (2022-07-01)

Repair of spinal cord injury by bone marrow mesenchymal stem cell-derived exosomes: a systematic review and meta-analysis based on rat models
by: Zhongduo Ye, et al.
Published: (2024-08-01)

Exosome-mediated repair of spinal cord injury: a promising therapeutic strategy
by: Tong Yu, et al.
Published: (2024-01-01)

The Value of MicroRNAs as an Indicator of the Severity and the Acute Phase of Spinal Cord Injury
by: Junyoung Park, et al.
Published: (2019-06-01)

Adipose-derived mesenchymal stem cell exosomes ameliorate spinal cord injury in rats by activating the Nrf2/HO-1 pathway and regulating microglial polarization
by: Yi Luo, et al.
Published: (2023-08-01)

Platelet-rich plasma-derived exosomes promote blood-spinal cord barrier repair and attenuate neuroinflammation after spinal cord injury
by: Xinyu Nie, et al.
Published: (2024-07-01)

Bone marrow mesenchymal stem cell exosomes-derived microRNA-216a-5p on locomotor performance, neuronal injury, and microglia inflammation in spinal cord injury
by: Hao Xue, et al.
Published: (2023-09-01)

Treg cells-derived exosomes promote blood-spinal cord barrier repair and motor function recovery after spinal cord injury by delivering miR-2861
by: Guang Kong, et al.
Published: (2023-10-01)

Exosomes derived from human placental mesenchymal stem cells in combination with hyperbaric oxygen synergically alleviates spinal cord ischemia-reperfusion injury
by: Aref Jafari, et al.
Published: (2023-12-01)

Stem cell-derived exosome treatment for acute spinal cord injury: a systematic review and meta-analysis based on preclinical evidence
by: Chunlin Mou, et al.
Published: (2025-01-01)

Exosomes and MicroRNAs: key modulators of macrophage polarization in sepsis pathophysiology
by: Mohamed J. Saadh, et al.
Published: (2025-04-01)

Small extracellular vesicles derived from umbilical cord mesenchymal stem cells repair blood-spinal cord barrier disruption after spinal cord injury through down-regulation of Endothelin-1 in rats
by: Chenhui Xue, et al.
Published: (2023-10-01)

Bibliometric Analysis of Exosome Research in Spinal Cord Injury (2000&ndash;May 2024). Trends, Collaborations, and Emerging Insights
by: Wang Z, et al.
Published: (2025-08-01)

How Advanced Are Exosomes as Cell-Free Therapeutics for Spinal Cord Injury?
by: Wu Y, et al.
Published: (2025-09-01)

Cell penetrating peptide modified M2 macrophage derived exosomes treat spinal cord injury and rheumatoid arthritis by loading curcumin
by: Zhuo Li, et al.
Published: (2023-01-01)

Mesenchymal Stem Cell-Derived Exosomal microRNAs in Cardiac Regeneration
by: Meghana Bhaskara, et al.
Published: (2023-12-01)

Mesenchymal Stem-Cell-Derived Exosomes and MicroRNAs: Advancing Cell-Free Therapy in Systemic Sclerosis
by: Cristiano Barbetta, et al.
Published: (2025-07-01)

Exosomes as promising bioactive materials in the treatment of spinal cord injury
by: Yueying Li, et al.
Published: (2024-09-01)

The Tumor Cytosol miRNAs, Fluid miRNAs and Exosome miRNAs in Lung Cancer
by: Xin eQin, et al.
Published: (2015-01-01)

An injectable decellularized extracellular matrix hydrogel with cortical neuron-derived exosomes enhances tissue repair following traumatic spinal cord injury
by: Gang Wang, et al.
Published: (2024-10-01)

Hypoxic exosomes alleviated the spinal cord injury after ischemic/reperfusion in a rat model
by: Mahdiyeh Asadzadeh Bavil, et al.
Published: (2025-07-01)

Rapid and effective treatment of traumatic spinal cord injury using stem cell derived exosomes
by: Jiafu Mu, et al.
Published: (2021-11-01)

From hope to healing: Exploring the therapeutic potential of exosomes in spinal cord injury
by: Nidhi Singh, et al.
Published: (2024-06-01)