Escalated (Dependent) Oxycodone Self-Administration Is Associated with Cognitive Impairment and Transcriptional Evidence of Neurodegeneration in Human Immunodeficiency Virus (HIV) Transgenic Rats

Substance use disorder is associated with accelerated disease progression in people with human immunodeficiency virus (HIV; PWH). Problem opioid use, including high-dose opioid therapy, prescription drug misuse, and opioid abuse, is high and increasing in the PWH population. Oxycodone is a broadly p...

Full description

Bibliographic Details
Published in:	Viruses
Main Authors:	Yu Fu, Irene Lorrai, Barry Zorman, Daniele Mercatelli, Chase Shankula, Jorge Marquez Gaytan, Celine Lefebvre, Giordano de Guglielmo, Hyunjae Ryan Kim, Pavel Sumazin, Federico M. Giorgi, Vez Repunte-Canonigo, Pietro Paolo Sanna
Format:	Article
Language:	English
Published:	MDPI AG 2022-03-01
Subjects:	neuroHIV AIDS neuroinflammation cognitive impairment
Online Access:	https://www.mdpi.com/1999-4915/14/4/669

Similar Items

CXCL12-induced rescue of cortical dendritic spines and cognitive flexibility
by: Lindsay K Festa, et al.
Published: (2020-01-01)

Morphine suppresses peripheral responses and transforms brain myeloid gene expression to favor neuropathogenesis in SIV infection
by: Howard S. Fox, et al.
Published: (2022-11-01)

Transmitted/founder SHIV.D replicates in the brain, causes neuropathogenesis, and persists on combination antiretroviral therapy in rhesus macaques
by: Rachel M. Podgorski, et al.
Published: (2023-08-01)

Movement-related beta and gamma oscillations indicate parallels and disparities between Alzheimer's disease and HIV-associated neurocognitive disorder
by: Chloe E. Meehan, et al.
Published: (2023-10-01)

Editorial: Advances in Understanding NeuroHIV Associated Changes in Neuroimmune Communication in the Combined Anti-retroviral Therapy (cART) Era
by: Peter J. Gaskill, et al.
Published: (2021-10-01)

Pitfalls of Antiretroviral Therapy: Current Status and Long-Term CNS Toxicity
by: Harrison Rudd, et al.
Published: (2022-06-01)

Identification, Quantification, and Characterization of HIV-1 Reservoirs in the Human Brain
by: Maribel Donoso, et al.
Published: (2022-08-01)

HIV-1 Tat alters neuronal intrinsic excitability
by: Walter Francesconi, et al.
Published: (2018-05-01)

Dopamine Levels Induced by Substance Abuse Alter Efficacy of Maraviroc and Expression of CCR5 Conformations on Myeloid Cells: Implications for NeuroHIV
by: Stephanie M. Matt, et al.
Published: (2021-05-01)

Non-Coding RNAs in HIV Infection, NeuroHIV, and Related Comorbidities
by: Seema Singh, et al.
Published: (2024-05-01)

A Rationale and Approach to the Development of Specific Treatments for HIV Associated Neurocognitive Impairment
by: Aaron Scanlan, et al.
Published: (2022-11-01)

HIV-Induced Hyperactivity of Striatal Neurons Is Associated with Dysfunction of Voltage-Gated Calcium and Potassium Channels at Middle Age
by: Christina E. Khodr, et al.
Published: (2022-07-01)

Nef is a key player in neuroinflammation and myelin impairment associated with neuroHIV
by: Michael Ilya Bukrinsky
Published: (2025-03-01)

Methamphetamine Increases the Proportion of SIV-Infected Microglia/Macrophages, Alters Metabolic Pathways, and Elevates Cell Death Pathways: A Single-Cell Analysis
by: Meng Niu, et al.
Published: (2020-11-01)

Dopamine D3 Receptor Antagonism Reverses the Escalation of Oxycodone Self-administration and Decreases Withdrawal-Induced Hyperalgesia and Irritability-Like Behavior in Oxycodone-Dependent Heterogeneous Stock Rats
by: Giordano de Guglielmo, et al.
Published: (2020-01-01)

Prospective Neuropsychological and Plasma Biomarker Changes in Treatment-Naïve People Living with HIV After Antiretroviral Treatment Initiation
by: Charalampos D. Moschopoulos, et al.
Published: (2025-07-01)

THC reverses SIV-induced senescence in astrocytes: possible compensatory mechanism against HIV associated brain injury?
by: Alison R. Van Zandt, et al.
Published: (2025-09-01)

HIV Protein TAT Dysregulates Multiple Pathways in Human iPSCs-Derived Microglia
by: Liam Liyang Guo, et al.
Published: (2025-07-01)

Inhibitory Neurotransmission Is Sex-Dependently Affected by Tat Expression in Transgenic Mice and Suppressed by the Fatty Acid Amide Hydrolase Enzyme Inhibitor PF3845 via Cannabinoid Type-1 Receptor Mechanisms
by: Changqing Xu, et al.
Published: (2022-03-01)

HIV and opiates dysregulate K+- Cl− cotransporter 2 (KCC2) to cause GABAergic dysfunction in primary human neurons and Tat-transgenic mice
by: Aaron J. Barbour, et al.
Published: (2020-07-01)

Escalated oxycodone self-administration is associated with expression of voltage gated and calcium activated potassium channels in the mesocorticolimbic system in rats
by: Ammanuel Y. Wabreha, et al.
Published: (2025-08-01)

Charge Characteristics of Agouti-Related Protein Implicate Potent Involvement of Heparan Sulfate Proteoglycans in Metabolic Function
by: Jihuan Chen, et al.
Published: (2019-12-01)

Oxycodone, an opioid like the others?
by: Nicolas Marie, et al.
Published: (2023-12-01)

Epidural Oxycodone for Acute Pain
by: Panu Piirainen, et al.
Published: (2022-05-01)

Effects of single and dual hypocretin-receptor blockade or knockdown of hypocretin projections to the central amygdala on alcohol drinking in dependent male rats
by: Gabriel M. Aldridge, et al.
Published: (2022-09-01)

CLONIDINE INHIBITS OXYCODONE-MOTIVATED BEHAVIORS, BRAIN STIMULATION REWARD AND POTENTIATES THE ANTINOCICEPTIVE EFFECTS OF OXYCODONE IN RODENTS
by: Ashton Taylor, et al.
Published: (2023-10-01)

Effects of sex and estrous cycle on intravenous oxycodone self-administration and the reinstatement of oxycodone-seeking behavior in rats
by: Nicole M. Hinds, et al.
Published: (2023-07-01)

Predator scent stress reduces oxycodone self-administration and the nucleus accumbens dopamine response to oxycodone in female rats
by: Courtney S. Wilkinson, et al.
Published: (2025-06-01)

Voluntary alcohol intake alters the motivation to seek intravenous oxycodone and neuronal activation during the reinstatement of oxycodone and sucrose seeking
by: Courtney S. Wilkinson, et al.
Published: (2023-11-01)

Quality of life under oxycodone/naloxone, oxycodone, or morphine treatment for chronic low back pain in routine clinical practice
by: Ueberall MA, et al.
Published: (2016-02-01)

An Unusual Case of Serotonin Syndrome with Oxycodone and Citalopram
by: Clare Walter, et al.
Published: (2012-01-01)

Social Networking Site Behaviors Across the Relational Lifespan: Measurement and Association With Relationship Escalation and De-escalation
by: Nicholas Brody, et al.
Published: (2016-11-01)

Genetic or pharmacological GHSR blockade has sexually dimorphic effects in rodents on a high-fat diet
by: András H. Lékó, et al.
Published: (2024-05-01)

Identification of Plasma Metabolites Responding to Oxycodone Exposure in Rats
by: Thao Vu, et al.
Published: (2025-02-01)

Acute Abdomen in a Patient with Cancer Pain on Oxycodone
by: Naomi Kishine, et al.
Published: (2011-01-01)

Role of Oxycodone Hydrochloride in Treating Radiotherapy-Related Pain
by: Yinxia Wang, et al.
Published: (2020-01-01)

Active CNS delivery of oxycodone in healthy and endotoxemic pigs
by: Frida Bällgren, et al.
Published: (2024-10-01)

Oxycodone as a replacement to opioid to facilitate tracheal intubation
by: Aninda Tanggono, et al.
Published: (2020-01-01)

Profile of extended-release oxycodone/acetaminophen for acute pain
by: Bekhit MH
Published: (2015-10-01)

Restless Leg Syndrome Induced by an Acute Withdrawal of Oxycodone
by: Joon Hyun Baek, et al.
Published: (2015-12-01)