Tardive Oculogyric Dystonia during Concomitant Quetiapine, Fluoxetine and Lithium Therapy: Case Report and Literature Review

Oculogyric crisis (OGC) is an acute paroxysmal sustained dystonia that occurs as an adverse drug event, commonly following first-generation antipsychotics and rarely with second-generation antipsychotics. We report a case of quetiapine (QTP)-induced disabling and stigmatizing tardive OGC developing...

Full description

Bibliographic Details
Published in:Journal of Psychiatry Spectrum
Main Authors: Ranganath R. Kulkarni, Swapna A. Pandurangi, Raghavendra C. Patil, R. Shantheri Pai
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2022-04-01
Subjects:
dystonia
fluoxetine
lithium
oculogyric crisis
quetiapine
tardive
Online Access:https://journals.lww.com/jops/fulltext/2022/01000/tardive_oculogyric_dystonia_during_concomitant.11.aspx
Description
Summary:Oculogyric crisis (OGC) is an acute paroxysmal sustained dystonia that occurs as an adverse drug event, commonly following first-generation antipsychotics and rarely with second-generation antipsychotics. We report a case of quetiapine (QTP)-induced disabling and stigmatizing tardive OGC developing after a month of its initiation, at a substantive low-dose (100 mg/day) in an ectomorphic young adult female during concomitant QTP, fluoxetine, and lithium therapy. It responded well to anticholinergic medications alone, without the need for dose-reduction or discontinuation of medications. We review literature on OGC due to QTP, fluoxetine and lithium; and discuss putative mechanisms leading to OGC in our case.
ISSN:2949-6969

Similar Items