LOX-1-Mediated Effects on Vascular Cells in Atherosclerosis

• الحاوية / القاعدة: Cellular Physiology and Biochemistry
• المؤلفون الرئيسيون: Dimitry A. Chistiakov, Alexander N. Orekhov, Yuri V. Bobryshev
• التنسيق: مقال
• اللغة: الإنجليزية
• منشور في: Cell Physiol Biochem Press GmbH & Co KG 2016-05-01
• الموضوعات: Atherosclerosis; Atherogenesis; Arteries; Lectin-like oxidized low-density lipoprotein receptor-1; LOX-1; Oxidized LDL; OxLDL
• الوصول للمادة أونلاين: http://www.karger.com/Article/FullText/443123

In healthy arteries, expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is almost undetectable. However, in proatherogenic conditions, LOX-1 is markedly up-regulated in vascular cells. In atherosclerosis, LOX-1 appears to be the key scavenger receptor for binding oxidized LDL (oxLDL). Notably, a positive feedback exists between LOX-1 and oxLDL. LOX-1 is involved in mediating of proatherosclerotic effects of oxLDL which result in endothelial dysfunction, proinflammatory recruitment of monocytes into the arterial intima, formation of foam cells, apoptosis of endothelial cells (ECs) and vascular smooth muscle cells (VSMCs), as well as in plaque destabilization and rupture. In this review, we consider effects of the LOX-1/oxLDL axis on several types of vascular cells such as ECs, VSMCs, and macrophages.