Sulphated Zirconia as an Eco-Friendly Catalyst in Acylal Preparation under Solvent-Free Conditions, Acylal Deprotection Assisted by Microwaves, and the Synthesis of Anhydro-Dimers of o-Hydroxybenzaldehydes

A solvent-free approach is described for the regioselective synthesis of acylals (1,1-diacetates) in shorter reaction times and higher yields, compared to conventional methodology using solvents. In the protection reaction of the o-hydroxybenzaldehyde the formation of acetyl compounds and anhydro-di...

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Bibliographic Details
Published in:Molecules
Main Authors: Gerardo Ulibarri, Eduardo González-Zamora, Laura Nadxieli Palacios-Grijalva, Leticia Lomas-Romero, Deysi Y. Cruz-González, Guillermo E. Negrón-Silva
Format: Article
Language:English
Published: MDPI AG 2009-10-01
Subjects:
sulphated zirconia
solvent-free
microwaves
regioselective
diacetates
Online Access:http://www.mdpi.com/1420-3049/14/10/4065/
Description
Summary:A solvent-free approach is described for the regioselective synthesis of acylals (1,1-diacetates) in shorter reaction times and higher yields, compared to conventional methodology using solvents. In the protection reaction of the o-hydroxybenzaldehyde the formation of acetyl compounds and anhydro-dimers was observed. The deprotection reaction involves microwave (MW) exposure of diluted reactants in the presence of solid sulphated zirconia (SZ) catalyst that can be easily recovered and reused. The sulphated zirconia was recycled several times without any loss of activity.
ISSN:1420-3049

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