AGEP overlap induced by hydroxychloroquine: a case report and literature review

Acute Generalized Exanthematous Pustulosis (AGEP) is a rare drug reaction manifesting as pustular lesions with surrounding erythema following exposure. The disease is often self-limited and treatment is supportive. It may present in an atypical variant with vesicles that desquamate into erosions, wh...

Full description

Bibliographic Details
Published in:	Journal of Community Hospital Internal Medicine Perspectives
Main Authors:	Christopher Mercogliano, Muhammad Khan, Catherine Lin, Elan Mohanty, Ryan Zimmerman
Format:	Article
Language:	English
Published:	Greater Baltimore Medical Center 2018-11-01
Subjects:	AGEP SJS/TEN overlap Plaquenil hydroxychloroquine acute generalized exanthematous pustulosis sero-negative arthritis
Online Access:	http://dx.doi.org/10.1080/20009666.2018.1547089

Similar Items

Multi‐institutional retrospective review of acute generalized exanthematous pustulosis (AGEP) induced by hydroxychloroquine
by: Alexander S. Bang, et al.
Published: (2024-06-01)

Ixekizumab for treatment of refractory acute generalized exanthematous pustulosis caused by hydroxychloroquine
by: Mohammad Munshi, MD, et al.
Published: (2020-07-01)

Hydroxychloroquine‐induced repetitive atypical pustular drug eruptions in the same patient separated by 12 years
by: Jeffrey Chen, et al.
Published: (2023-07-01)

Naltrexone-induced acute generalized exanthematous pustulosis
by: Jason Eakes, BS, et al.
Published: (2023-09-01)

Recurrent pediatric acute generalized exanthematous pustulosis with drug and infective precipitants
by: An Jian Leung, MBBS, MRCP (Int Med), MMed (S’pore), et al.
Published: (2025-01-01)

A case of acute generalized exanthematous pustulosis following COVID‐19 infection and remdesivir
by: Yasamin Kalantari, et al.
Published: (2023-06-01)

Leucomycin-induced acute generalized exanthematous pustulosis complicated with pitting edema of the legs
by: Chu-Ju Hung, et al.
Published: (2015-09-01)

Paediatric Acute Generalised and Localised Exanthematous Pustulosis: A Systematic Review
by: Miranda K. Branyiczky, et al.
Published: (2026-06-01)

Acute Generalized Exanthematous Pustulosis in a 76-year-Old Man With Neuroendocrine Carcinoma of the Lung, Responsive to Ixekizumab
by: Zhang J, et al.
Published: (2025-02-01)

Isotretinoin – Induced AGEP: A Case Report
by: Alotaibi HM, et al.
Published: (2025-02-01)

Severe Cutaneous Adverse Drug Reaction
by: Damayanti Damayanti, et al.
Published: (2017-08-01)

Diffuse pustules overlying brightly erythematous plaques in skin of color
by: Angela L. Zhang, BA, et al.
Published: (2025-02-01)

Clinical features of acute generalized exanthematous pustulosis caused by hydroxychloroquine in rheumatology patients and exploration of CARD14 gene mutations
by: Feng Luo, et al.
Published: (2023-04-01)

A case of recalcitrant acute generalized exanthematous pustulosis with Sjogren's syndrome: Successfully treated with low‐dose cyclosporine
by: Zeynep Gizem Kaya İslamoğlu, et al.
Published: (2019-09-01)

High Grade Dermatologic Adverse Events Associated With Immune Checkpoint Blockade for Cancer
by: Alyce M. Kuo, et al.
Published: (2022-06-01)

Upadacitinib Coadministered with Methylprednisolone for Effective Treatment of SJS/TEN Overlap Syndrome: A Case Report
by: Zhou X, et al.
Published: (2025-08-01)

Photoinduced acute exanthematous pustulosis caused by dicloxacillin and exposure to sunlight
by: Rikke M. Nielsen, et al.
Published: (2020-03-01)

Acute Generalized Exanthematous Pustulosis (AGEP) Caused by Antibiotic Polytherapy: a Case Report
by: Siniša Jolić, et al.
Published: (2024-01-01)

Acute generalized exanthematous pustulosis and Stevens-Johnson syndrome overlap due to hydroxychloroquine: a case report
by: Ivorie Coleman, et al.
Published: (2020-11-01)

Case Report: Infliximab for hydroxychloroquine-induced AGEP with IL17A and IL36RN mutations: a case report and management considerations
by: Xiaoyun Jiang, et al.
Published: (2025-07-01)

Successful Use of Bimekizumab in Refractory Acute Generalised Exanthematous Pustulosis Triggered by Amoxicillin‐Clavulanate
by: Alexandra Junge, et al.
Published: (2026-06-01)

Pericentral hydroxychloroquine retinopathy in a Caucasian female
by: Nikhil Anand, et al.
Published: (2018-03-01)

Combination testing confirming clindamycin induced acute generalized exanthematous pustulosis
by: Vinh-An Vo, MD, et al.
Published: (2025-09-01)

Acute generalized exanthematous pustulosis induced by Moderna COVID-19 messenger RNA vaccine
by: Anna Agaronov, BS, et al.
Published: (2021-10-01)

Acute localized exanthematous pustulosis induced by fosfomycin
by: Ibrahim Alfuraih, MD, et al.
Published: (2023-06-01)

Acute generalized exanthematous pustulosis sine pustules following semaglutide injection
by: Nayha P. Shetty, MD, et al.
Published: (2024-09-01)

Acute generalized exanthematous pustulosis associated with human parvovirus B19 infection
by: Juliette Coursier, et al.
Published: (2025-08-01)

Causative drugs and clinical outcome in Stevens Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN), and SJS-TEN overlap in children
by: Gomathy Sethuraman, et al.
Published: (2012-01-01)

A Case Report of Possibly Related Acute Generalized Exanthematous Pustulosis with Staphylococcus pettenkoferi
by: Wang S, et al.
Published: (2023-03-01)

Acute localized exanthematous pustulosis caused by cefoperazone and sodium sulbactam
by: Yan-Jing Qu, et al.
Published: (2016-12-01)

Acute Generalized Exanthematous Pustulosis with Multiple Organ Failure
by: Tausif Syed, et al.
Published: (2021-01-01)

Acute generalized exanthematous pustulosis induced by duloxetine
by: Numa Deydier, et al.
Published: (2023-06-01)

Stability data of extemporaneous suspensions of hydroxychloroquine sulphate in oral liquid bases after tablet manipulation
by: Mara Perrone, et al.
Published: (2020-12-01)

Development and initial validation of a modified lymphocyte transformation test (LTT) assay in patients with DRESS and AGEP
by: Chris Weir, et al.
Published: (2022-10-01)

The HIT Study—The Hydroxychloroquine Effect in the Treatment of Patients with Age-Related Macular Degeneration: A Randomized Controlled Trial
by: Tal Yahalomi, et al.
Published: (2023-03-01)

Stevens-Johnson syndrome-toxic epidermal necrolysis spectrum reactions to immune checkpoint inhibitor therapy and safety of rechallenge: A retrospective review
by: Gunnar Mattson, MD, MPH, et al.
Published: (2025-10-01)

Severe Cutaneous Adverse Reaction Caused by Carbamazepine and Levofloxacin After Varicella Zoster Virus Infection
by: Wang M, et al.
Published: (2023-03-01)

Acute generalized exanthematous pustulosis triggered by dupilumab
by: Caterina Mariarosaria Giorgio, et al.
Published: (2025-07-01)

Acute generalized exanthematous pustulosis related to phenytoin administration. Case report
by: Juan Raul Castro-Ayarza, et al.
Published: (2016-07-01)

Acute generalized exanthematous pustulosis induced by sulfasalazine: Uncommon presentation of a common culprit
by: Deepak Vashisht, et al.
Published: (2022-01-01)