Multi-scale simulations of the T cell receptor reveal its lipid interactions, dynamics and the arrangement of its cytoplasmic region.

The T cell receptor (TCR-CD3) initiates T cell activation by binding to peptides of Major Histocompatibility Complexes (pMHC). The TCR-CD3 topology is well understood but the arrangement and dynamics of its cytoplasmic tails remains unknown, limiting our grasp of the signalling mechanism. Here, we u...

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Bibliographic Details

Published in:	PLoS Computational Biology
Main Authors:	Dheeraj Prakaash, Graham P Cook, Oreste Acuto, Antreas C Kalli
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2021-07-01
Online Access:	https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009232&type=printable