Plant Terpenoids as Hit Compounds against Trypanosomiasis
Human African trypanosomiasis (sleeping sickness) and American trypanosomiasis (Chagas disease) are vector-borne neglected tropical diseases, caused by the protozoan parasites <i>Trypanosoma brucei</i> and <i>Trypanosoma cruzi</i>, respectively. These diseases were circumscri...
| الحاوية / القاعدة: | Pharmaceuticals |
|---|---|
| المؤلفون الرئيسيون: | , , , , |
| التنسيق: | مقال |
| اللغة: | الإنجليزية |
| منشور في: |
MDPI AG
2022-03-01
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://www.mdpi.com/1424-8247/15/3/340 |
| _version_ | 1851939319079501824 |
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| author | Raquel Durão Cátia Ramalhete Ana Margarida Madureira Eduarda Mendes Noélia Duarte |
| author_facet | Raquel Durão Cátia Ramalhete Ana Margarida Madureira Eduarda Mendes Noélia Duarte |
| author_sort | Raquel Durão |
| collection | DOAJ |
| container_title | Pharmaceuticals |
| description | Human African trypanosomiasis (sleeping sickness) and American trypanosomiasis (Chagas disease) are vector-borne neglected tropical diseases, caused by the protozoan parasites <i>Trypanosoma brucei</i> and <i>Trypanosoma cruzi</i>, respectively. These diseases were circumscribed to South American and African countries in the past. However, human migration, military interventions, and climate changes have had an important effect on their worldwide propagation, particularly Chagas disease. Currently, the treatment of trypanosomiasis is not ideal, becoming a challenge in poor populations with limited resources. Exploring natural products from higher plants remains a valuable approach to find new hits and enlarge the pipeline of new drugs against protozoal human infections. This review covers the recent studies (2016–2021) on plant terpenoids, and their semi-synthetic derivatives, which have shown promising in vitro and in vivo activities against Trypanosoma parasites. |
| format | Article |
| id | doaj-art-eefda3c2da2240f0893ecd8b3138b0bb |
| institution | Directory of Open Access Journals |
| issn | 1424-8247 |
| language | English |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| spelling | doaj-art-eefda3c2da2240f0893ecd8b3138b0bb2025-08-19T21:51:02ZengMDPI AGPharmaceuticals1424-82472022-03-0115334010.3390/ph15030340Plant Terpenoids as Hit Compounds against TrypanosomiasisRaquel Durão0Cátia Ramalhete1Ana Margarida Madureira2Eduarda Mendes3Noélia Duarte4Research Institute for Medicines (iMED.Ulisboa), Faculdade de Farmácia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, PortugalResearch Institute for Medicines (iMED.Ulisboa), Faculdade de Farmácia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, PortugalResearch Institute for Medicines (iMED.Ulisboa), Faculdade de Farmácia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, PortugalResearch Institute for Medicines (iMED.Ulisboa), Faculdade de Farmácia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, PortugalResearch Institute for Medicines (iMED.Ulisboa), Faculdade de Farmácia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, PortugalHuman African trypanosomiasis (sleeping sickness) and American trypanosomiasis (Chagas disease) are vector-borne neglected tropical diseases, caused by the protozoan parasites <i>Trypanosoma brucei</i> and <i>Trypanosoma cruzi</i>, respectively. These diseases were circumscribed to South American and African countries in the past. However, human migration, military interventions, and climate changes have had an important effect on their worldwide propagation, particularly Chagas disease. Currently, the treatment of trypanosomiasis is not ideal, becoming a challenge in poor populations with limited resources. Exploring natural products from higher plants remains a valuable approach to find new hits and enlarge the pipeline of new drugs against protozoal human infections. This review covers the recent studies (2016–2021) on plant terpenoids, and their semi-synthetic derivatives, which have shown promising in vitro and in vivo activities against Trypanosoma parasites.https://www.mdpi.com/1424-8247/15/3/340terpenoidsTrypanosomahuman African trypanosomiasissleeping diseasehuman American trypanosomiasisChagas disease |
| spellingShingle | Raquel Durão Cátia Ramalhete Ana Margarida Madureira Eduarda Mendes Noélia Duarte Plant Terpenoids as Hit Compounds against Trypanosomiasis terpenoids Trypanosoma human African trypanosomiasis sleeping disease human American trypanosomiasis Chagas disease |
| title | Plant Terpenoids as Hit Compounds against Trypanosomiasis |
| title_full | Plant Terpenoids as Hit Compounds against Trypanosomiasis |
| title_fullStr | Plant Terpenoids as Hit Compounds against Trypanosomiasis |
| title_full_unstemmed | Plant Terpenoids as Hit Compounds against Trypanosomiasis |
| title_short | Plant Terpenoids as Hit Compounds against Trypanosomiasis |
| title_sort | plant terpenoids as hit compounds against trypanosomiasis |
| topic | terpenoids Trypanosoma human African trypanosomiasis sleeping disease human American trypanosomiasis Chagas disease |
| url | https://www.mdpi.com/1424-8247/15/3/340 |
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