Magnetic copper nanoparticle catalyst on β-cyclodextrin-modifed AlFe2O4 for efficient green synthesis 1H-pyrazolo[1,2-b]phthalazine-5,10-diones

This study reports a green, efficient synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones using a novel magnetic copper nanoparticle catalyst, Cu@β-CD@AlFe₂O₄. The catalyst, prepared by anchoring copper onto β-cyclodextrin-modified AlFe₂O₄, was characterized via SEM, TEM, XRD, and FT-IR. Reaction...

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Bibliographic Details
Published in:Results in Chemistry
Main Authors: Zahra Moghadasi, Jayanti Makasana, Suhas Ballal, Munther Kadheem, Abhayveer Singh, Kattela Chennakesavulu, Pushpa Negi Bhakuni
Format: Article
Language:English
Published: Elsevier 2025-07-01
Subjects:
(cu@β-CD@AlFe2O4 NPs)
Magnetic nanoparticle catalyst
Microwave synthesis
Β-Cyclodextrin
Green synthesis
1H-pyrazolo[1,2-b]phthalazine-5,10-diones
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715625003984
Description
Summary:This study reports a green, efficient synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones using a novel magnetic copper nanoparticle catalyst, Cu@β-CD@AlFe₂O₄. The catalyst, prepared by anchoring copper onto β-cyclodextrin-modified AlFe₂O₄, was characterized via SEM, TEM, XRD, and FT-IR. Reactions with malonitrile, aromatic aldehydes, and phthalhydrazide were carried out under solvent-free microwave conditions at room temperature, yielding remarkably high product yields (89–97 %) over 18 examples. The catalyst is highly reusable, retaining efficiency after five cycles. This work showcases the potential of magnetic nanocatalysts for eco-friendly organic synthesis.
ISSN:2211-7156

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