FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons.

Sphingosine-1-phosphate (S1P) is a pluripotent lipophilic mediator working as a ligand for G-protein coupled S1P receptors (S1PR), which is currently highlighted as a therapeutic target for autoimmune diseases including relapsing forms of multiple sclerosis. Sphingosine related compounds, FTY720 and...

Full description

Bibliographic Details
Published in:	PLoS ONE
Main Authors:	Nobumasa Takasugi, Tomoki Sasaki, Ihori Ebinuma, Satoko Osawa, Hayato Isshiki, Koji Takeo, Taisuke Tomita, Takeshi Iwatsubo
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2013-01-01
Online Access:	http://europepmc.org/articles/PMC3646787?pdf=render

Similar Items

Sphingosine 1-Phosphate Receptor Modulator Fingolimod (FTY720) Attenuates Myocardial Fibrosis in Post-heterotopic Heart Transplantation
by: Naseer Ahmed, et al.
Published: (2017-09-01)

The Immunosuppressant FTY720 (Fingolimod) enhances Glycosaminoglycan depletion in articular cartilage
by: Stradner Martin H, et al.
Published: (2011-12-01)

The Immunosuppressant Fingolimod (FTY720) for the Treatment of Mechanical Force-Induced Abnormal Scars
by: Masayo Aoki, et al.
Published: (2020-01-01)

Fingolimod (FTY720) stimulates Ca(2+)/calcineurin signaling in fission yeast.
by: Kanako Hagihara, et al.
Published: (2013-01-01)

FTY720-derivatives do not induce FTY720-like lymphopenia
by: Ismael Segura-Ulate, et al.
Published: (2017-03-01)

Effects of FTY720 (Fingolimod) on Proliferation, Differentiation, and Migration of Brain-Derived Neural Stem Cells
by: Botao Tan, et al.
Published: (2016-01-01)

Behavioral Analyses in Dark Agouti Rats Following Repeated Systemic Treatment With Fingolimod (FTY720)
by: Marie Jakobs, et al.
Published: (2024-11-01)

The functional antagonist of sphingosine-1-phosphate, FTY720, impairs gut barrier function
by: Sohini Sikdar, et al.
Published: (2024-08-01)

The Effects of the S1P Receptor Agonist Fingolimod (FTY720) on Central and Peripheral Myelin in Twitcher Mice
by: Sibylle Béchet, et al.
Published: (2024-03-01)

Effect of FTY720 (fingolimod) on graft survival in renal transplant recipients: a systematic review protocol
by: Reza Gholamnezhadjafari, et al.
Published: (2016-04-01)

Fingolimod (FTY720) Tedavisinin Relapsing-Remitting Multipl Skleroz Hastalarında Karaciğer Enzim Düzeylerine Etkisi
by: Duygu Tap, et al.
Published: (2020-12-01)

Fingolimod (FTY720) improves postoperative cognitive dysfunction in mice subjected to D-galactose-induced aging
by: Jie Zhang, et al.
Published: (2020-01-01)

Sex-dependent efficacy of sphingosine-1-phosphate receptor agonist FTY720 in mitigating Huntington’s disease
by: Jingyun Wu, et al.
Published: (2025-01-01)

Ameliorative effects of Fingolimod (FTY720) on microglial activation and psychosis-related behavior in short term cuprizone exposed mice
by: Siyao Li, et al.
Published: (2023-07-01)

Fingolimod (FTY720), a Sphinogosine-1-Phosphate Receptor Agonist, Mitigates Choroidal Endothelial Proangiogenic Properties and Choroidal Neovascularization
by: Christine M. Sorenson, et al.
Published: (2022-03-01)

Immunomodulatory drug fingolimod (FTY720) restricts the growth of opportunistic yeast Candida albicans in vitro and in a mouse candidiasis model
by: Niloofar Najarzadegan, et al.
Published: (2022-01-01)

Immunomodulatory drug fingolimod (FTY720) restricts the growth of opportunistic yeast Candida albicans in vitro and in a mouse candidiasis model.
by: Niloofar Najarzadegan, et al.
Published: (2022-01-01)

Actions of FTY720 (Fingolimod), a Sphingosine-1-Phosphate Receptor Modulator, on Delayed-Rectifier K<sup>+</sup> Current and Intermediate-Conductance Ca<sup>2+</sup>-Activated K<sup>+</sup> Channel in Jurkat T-Lymphocytes
by: Wei-Ting Chang, et al.
Published: (2020-10-01)

Pharmacokinetic/pharmacodynamic relationships of FTY720 in kidney transplant recipients
by: S.I. Park, et al.
Published: (2005-05-01)

Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A‐RIPK1‐dependent necroptosis
by: Sahar A. Saddoughi, et al.
Published: (2012-11-01)

Presynaptic Release-Regulating Sphingosine 1-Phosphate 1/3 Receptors in Cortical Glutamatergic Terminals: Adaptations in EAE Mice and Impact of Therapeutic FTY720
by: Alessandra Roggeri, et al.
Published: (2023-09-01)

Effect of FTY720 on Angiotensin Ⅱ-mediated chronic kidney diseases
by: HAN Qi, et al.
Published: (2019-01-01)

Effect of FTY720P on lipid accumulation in HEPG2 cells
by: Reem Rida, et al.
Published: (2023-11-01)

Effects of FTY720 on Lung Injury Induced by Hindlimb Ischemia Reperfusion in Rats
by: Liangrong Wang, et al.
Published: (2017-01-01)

Anti-tumor drug FTY720 regulates p53-dependent transcription
by: YAO Han, XU Wen-bin, WANG Dong-lai
Published: (2021-03-01)

Effect of FTY720 on transfusion-related acute lung injury: a preliminary investigation
by: Yaling ZHOU, et al.
Published: (2023-05-01)

FTY720 in immuno-regenerative and wound healing technologies for muscle, epithelial and bone regeneration
by: Monica Behara, et al.
Published: (2023-05-01)

FTY720 Attenuates Angiotensin II-Induced Podocyte Damage via Inhibiting Inflammatory Cytokines
by: Ke Su, et al.
Published: (2017-01-01)

Sphingomimetic multiple sclerosis drug FTY720 activates vesicular synaptobrevin and augments neuroendocrine secretion
by: Frederic D. Darios, et al.
Published: (2017-07-01)

Effects of FTY720 on brain neurogenic niches in vitro and after kainic acid-induced injury
by: Raffaela Cipriani, et al.
Published: (2017-07-01)

FTY720 在大鼠肾脏缺血再灌注损伤中的作用
Published: (2005-01-01)

A genome-wide screen for FTY720-sensitive mutants reveals genes required for ROS homeostasis
by: Kanako Hagihara, et al.
Published: (2017-11-01)

FTY720 Effects on Inflammation and Liver Damage in a Rat Model of Renal Ischemia-Reperfusion Injury
by: Anthony D. Foster, et al.
Published: (2019-01-01)

Administration of FTY720 during Tourniquet-Induced Limb Ischemia Reperfusion Injury Attenuates Systemic Inflammation
by: Anthony D. Foster, et al.
Published: (2017-01-01)

FTY720 Reduces the Biomass of Biofilms in <i>Pseudomonas aeruginosa</i> in a Dose-Dependent Manner
by: Abdurahman A. Niazy, et al.
Published: (2024-07-01)

FTY720 increases sensitivity of Temozolomid due to down-regulation of N-Cadherin expression in glioblastoma cells
by: Malgorzata Kolodziej
Published: (2023-01-01)

Signaling Cascade Mediating the Effect of FTY720P on the Na+/K+ ATPase in LLC-PK1
by: Christine Khalil, et al.
Published: (2022-08-01)

FTY720 controls disease severity and attenuates sciatic nerve damage in chronic experimental autoimmune neuritis
by: Laurent Kremer, et al.
Published: (2019-03-01)

FTY720 预防小鼠同种异体胰岛移植的排斥反应
Published: (2006-01-01)

Injectable Hydrogel Loaded with CDs and FTY720 Combined with Neural Stem Cells for the Treatment of Spinal Cord Injury
by: Qi Z, et al.
Published: (2024-05-01)