| Summary: | Parabens are used as preservatives in sanitizers and cosmetic products causing environmental concern, because presented potential as endocrine disrupters. Among these compounds, the most used are methylparaben and propylparaben. Thus, a study was proposed to evaluate the interaction between different concentrations (mmol L-1) of the variables methylparaben [MP] and propylparaben [PP], against the acute toxicity of the microcrustacean Artemia salina (A. salina) and Allium cepa (A. cepa) applying the 22 factorial design with an added center point. Responses were used: percent A. salina mortality (% mortality), A. cepa root growth inhibition (% root inhibition) and mitotic index (%MI). For A. salina, after 72 hours of exposure with the combination of concentration ([MP] and [PP] = 0.8 mmol L−1) caused an 80% mortality. While, A. cepa a high cytotoxicity was observed with the mixture of Parabens, exhibiting 72.3% root growth inhibition at [MP] = 1.2 mmol L-1 with [PP] = 1.2 mmol L-1. In contrast, for response %MI at [MP] = 0.3 mmol L-1 with [PP] = 0.3 mmol L-1, 2.5 %MI with 36% inhibition. In this context, parabens demonstrated high toxicity for A. salina and cytotoxicity for A. cepa, based on the interaction with the effect of the concentrations.
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