Prognostic Role of Pre- and Post-Treatment [18F]FDG PET/CT in Squamous Cell Carcinoma of the Oropharynx in Patients Treated with Chemotherapy and Radiotherapy

• الحاوية / القاعدة: Medical Sciences
• المؤلفون الرئيسيون: Francesco Dondi, Maria Gazzilli, Domenico Albano, Alessio Rizzo, Giorgio Treglia, Antonio Rosario Pisani, Carmen Palumbo, Dino Rubini, Manuela Racca, Giuseppe Rubini, Francesco Bertagna
• التنسيق: مقال
• اللغة: الإنجليزية
• منشور في: MDPI AG 2024-07-01
• الموضوعات: [18]F-FDG; positron emission tomography; PET/CT; oropharynx; head and neck; squamous cell carcinoma
• الوصول للمادة أونلاين: https://www.mdpi.com/2076-3271/12/3/36
• تدمد: 2076-3271

Background: The prognostic role of imaging with [18F]fluorodeoxyglucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) in oropharynx cancer (OPC) has been demonstrated in the past. The aim of this study was to assess the prognostic impact of both baseline and post-treatment PET/CT in patients with OPC and treated with chemo- and/or radiotherapy. Methods: The PET/CT parameters of scans performed before and after therapy were collected and analyzed to find significant prognosticators for progression-free survival (PFS) and overall survival (OS). Human papillomavirus (HPV) infection’s influence on the prognosis was also taken into account. Results: A total of 66 patients were included in the study. The staging volumetric parameters of PET/CT were significant prognosticators for OS, while the same parameters were affordable predictors for PFS at the restaging evaluation. No significant correlations between HPV infection and PET/CT parameters were reported. Conclusion: The prognostic role of volumetric [18F]FDG PET/CT parameters in patients with OPC was reported.