A gH/gL-encoding replicon vaccine elicits neutralizing antibodies that protect humanized mice against EBV challenge

Abstract Epstein-Barr virus (EBV) is associated with several malignancies, neurodegenerative disorders and is the causative agent of infectious mononucleosis. A vaccine that prevents EBV-driven morbidity and mortality remains an unmet need. EBV is orally transmitted, infecting both B cells and epith...

Full description

Bibliographic Details
Published in:	npj Vaccines
Main Authors:	Kristina R. Edwards, Harman Malhi, Karina Schmidt, Amelia R. Davis, Leah J. Homad, Nikole L. Warner, Crystal B. Chhan, Samuel C. Scharffenberger, Karen Gaffney, Troy Hinkley, Nicole B. Potchen, Jing Yang Wang, Jason Price, M. Juliana McElrath, James Olson, Neil P. King, Jennifer M. Lund, Zoe Moodie, Jesse H. Erasmus, Andrew T. McGuire
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-06-01
Online Access:	https://doi.org/10.1038/s41541-024-00907-y

Similar Items

EBV gL-gH344-Ferritin Nanoparticle Vaccine Elicits Robust Immune Responses in Mice
by: Chenyu Li, et al.
Published: (2025-05-01)

The murid herpesvirus-4 gH/gL binds to glycosaminoglycans.
by: Laurent Gillet, et al.
Published: (2008-02-01)

Antibodies Targeting KSHV gH/gL Reveal Distinct Neutralization Mechanisms
by: Thomas Fricke, et al.
Published: (2022-03-01)

Human cytomegalovirus vaccine based on the envelope gH/gL pentamer complex.
by: Felix Wussow, et al.
Published: (2014-11-01)

Well Put Together—A Guide to Accessorizing with the Herpesvirus gH/gL Complexes
by: Gonzalo L. Gonzalez-Del Pino, et al.
Published: (2022-01-01)

Correction: The Murid Herpesvirus-4 gL Regulates an Entry-Associated Conformation Change in gH
Published: (2008-01-01)

Correction: The Murid Herpesvirus-4 gL Regulates an Entry-Associated Conformation Change in gH.
by: Laurent Gillet, et al.
Published: (2008-01-01)

Human cytomegalovirus glycoprotein complex gH/gL/gO uses PDGFR-α as a key for entry.
by: Yiquan Wu, et al.
Published: (2017-04-01)

Targeting RSV-neutralizing B cell receptors with anti-idiotypic antibodies
by: Samuel C. Scharffenberger, et al.
Published: (2024-10-01)

Generation of chimeric forms of rhesus macaque rhadinovirus expressing KSHV envelope glycoproteins gH and gL for utilization in an NHP model of infection
by: Ryan D. Estep, et al.
Published: (2025-02-01)

A neutralizing anti-gH/gL monoclonal antibody is protective in the guinea pig model of congenital CMV infection.
by: Marcy R Auerbach, et al.
Published: (2014-04-01)

Single-dose replicon RNA Sudan virus vaccine uniformly protects female guinea pigs from disease
by: Kyle L. O’Donnell, et al.
Published: (2025-05-01)

The viral chemokine MCK-2 of murine cytomegalovirus promotes infection as part of a gH/gL/MCK-2 complex.
by: Felicia M Wagner, et al.
Published: (2013-01-01)

Human cytomegalovirus gH/gL/gO binding to PDGFRα provides a regulatory signal activating the fusion protein gB that can be blocked by neutralizing antibodies
by: Eric P. Schultz, et al.
Published: (2025-05-01)

Low gH/gL (Sub)Species-Specific Antibody Levels Indicate Elephants at Risk of Fatal Elephant Endotheliotropic Herpesvirus Hemorrhagic Disease
by: Tabitha E. Hoornweg, et al.
Published: (2024-02-01)

Receptor Binding-Induced Conformational Changes in Herpes Simplex Virus Glycoprotein D Permit Interaction with the gH/gL Complex to Activate Fusion
by: Doina Atanasiu, et al.
Published: (2023-03-01)

Two Sides to Every Story: Herpes Simplex Type-1 Viral Glycoproteins gB, gD, gH/gL, gK, and Cellular Receptors Function as Key Players in Membrane Fusion
by: Nithya Jambunathan, et al.
Published: (2021-09-01)

Complete protection of mice against lethal murine cytomegalovirus challenge by immunization with DNA vaccines encoding envelope glycoprotein complex III antigens gH, gL and gO.
by: Huadong Wang, et al.
Published: (2015-01-01)

Fetal human cytomegalovirus transmission correlates with delayed maternal antibodies to gH/gL/pUL128-130-131 complex during primary infection.
by: Daniele Lilleri, et al.
Published: (2013-01-01)

Association of plasminogen activator inhibitor-type 1 (-675 4G/5G) polymorphism with pre-eclampsia: systematic review.
by: Jessie A Morgan, et al.
Published: (2013-01-01)

Cognitive Dissonance Identification in the Institutional Setting of the Academic Library
by: Eileen McElrath
Published: (2004-03-01)

Neutralizing Antibodies Protect against Oral Transmission of Lymphocryptovirus
by: Swati Singh, et al.
Published: (2020-06-01)

G.L. Cleintuar, Wisselend getij. Geschiedenis van de Zuiderzeevereeniging 1886-1949
by: G. Taal
Published: (1984-01-01)

The adjuvant activity of alphavirus replicons is enhanced by incorporating the microbial molecule flagellin into the replicon.
by: Maria L Knudsen, et al.
Published: (2013-01-01)

Replicon-Based Typing About IncG Plasmids and Molecular Characterization of Five IncG Plasmids Carrying Carbapenem Resistance Gene blaKPC-2
by: Guo H, et al.
Published: (2024-07-01)

G.L. Lindner, Parlementaire geschiedenis van het militaire straf-, strafproces- en tuchtrecht
by: E.L. Gonsalves
Published: (1994-01-01)

On Bethe vectors in gl3 $$ \mathfrak{g}{\mathfrak{l}}_3 $$-invariant integrable models
by: A. Liashyk, et al.
Published: (2018-06-01)

THE ROLE OF anti-EBNA1 IgG DETERMINATION IN EBV DIAGNOSTICS
by: Tsvetelina Kostadinova, et al.
Published: (2018-09-01)

Priming VRC01-precursor B cells with non-envelope immunogens disfavors boosting with HIV-1 envelope
by: Andrew Wilcox-King, et al.
Published: (2025-08-01)

<i>gL</i>1 Scheme for Solving a Class of Generalized Time-Fractional Diffusion Equations
by: Xuhao Li, et al.
Published: (2022-04-01)

Several Characteristics of <i>Oidiodendron maius</i> G.L. Barron Important for Heather Plants’ Controlled Mycorrhization
by: Vyacheslav S. Mikheev, et al.
Published: (2023-07-01)

Alphavirus Replicon Particle Vaccine Breaks B Cell Tolerance and Rapidly Induces IgG to Murine Hematolymphoid Tumor Associated Antigens
by: Hsuan Su, et al.
Published: (2022-05-01)

ebv-sisRNA-3 contributes to the formation of G4-associated R-loop upstream of EBV lytic replication origin in latently infected cells
by: Bo Wang, et al.
Published: (2025-06-01)

Comparison of Helicobacter bilis-Associated Protein Expression in Huh7 Cells Harbouring HCV Replicon and in Replicon-Cured Cells
by: Arinze S. Okoli, et al.
Published: (2012-01-01)

Association of G12D mutation in the KRAS gene with HPV and EBV in gastrointestinal cancer tissues
by: Vahideh Hamidi Sofiani, et al.
Published: (2024-12-01)

A rewinding model for replicons with DNA-links
by: Abdul Adheem Mohamad, et al.
Published: (2020-02-01)

Lightweight Application Of Signal BIM Models Based On GlTF And WebGL
by: Yunshui Zheng, et al.
Published: (2023-02-01)

A Single Amino Acid Substitution in the Transmembrane Domain of Glycoprotein H Functionally Compensates for the Absence of gL in Pseudorabies Virus
by: Melina Vallbracht, et al.
Published: (2023-12-01)

Yang-Baxter deformations of the $$GL(2,{\mathbb {R}})$$ G L ( 2 , R ) WZW model and non-Abelian T-duality
by: Ali Eghbali, et al.
Published: (2023-10-01)

Self-Amplifying Replicon RNA Delivery to Dendritic Cells by Cationic Lipids
by: Pavlos C. Englezou, et al.
Published: (2018-09-01)