Mechanisms and Molecular Targets of BuShenHuoXue Formula for Osteoarthritis

Bibliographic Details
Published in:	ACS Omega
Main Authors:	Wen Xiong, Jiazheng Zhao, Xiaowei Ma, Zhangying Feng
Format:	Article
Language:	English
Published:	American Chemical Society 2022-01-01
Online Access:	https://doi.org/10.1021/acsomega.1c07270

Analysis of the Potential Angiogenic Mechanisms of BuShenHuoXue Decoction against Osteonecrosis of the Femoral Head Based on Network Pharmacology and Experimental Validation
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Bu Shen Huo Xue Formula Provides Neuroprotection Against Spinal Cord Injury by Inhibits Oxidative Stress by Activating the Nrf2 Signaling Pathway
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An Integration of RNA Sequencing and Network Pharmacology Approaches Predicts the Molecular Mechanisms of the Huo-Xue-Shen Formula in the Treatment of Liver Fibrosis
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BuShen HuoXue decoction improves fertility through intestinal hsp-16.2-mediated heat-shock signaling pathway in Caenorhabditis elegans
by: Kanglu Wu, et al.
Published: (2023-06-01)

Bu-Fei-Huo-Xue capsule alleviates bleomycin-induced pulmonary fibrosis in mice through modulating gut microbiota
by: Haibo Hu, et al.
Published: (2023-02-01)

Efficacy and safety of the Chinese herbal medicine Bu-Shen-Huo-Xue granule for the treatment of coronary heart disease: study protocol for a multicenter, randomized, double-blinded, placebo-controlled clinical trial
by: Lanchun Liu, et al.
Published: (2024-06-01)

Network Pharmacology Analysis and Machine-Learning Models Confirmed the Ability of YiShen HuoXue Decoction to Alleviate Renal Fibrosis by Inhibiting Pyroptosis
by: Feng M, et al.
Published: (2023-10-01)

Herbal HuoXueTongFu Formula with anti-inflammatory and fibrinolytic activity regulation for the prevention of postoperative peritoneal adhesions
by: Lili Yang, et al.
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Network Pharmacology and Molecular Docking Study on the Potential Mechanism of Yi-Qi-Huo-Xue-Tong-Luo Formula in Treating Diabetic Peripheral Neuropathy
by: Yixuan Lin, et al.
Published: (2021-01-01)

Huo Xue Tong Luo capsule, a vasoactive herbal formula prevents progression of asymptomatic osteonecrosis of femoral head: A prospective study
by: Qiu-Shi Wei, et al.
Published: (2019-07-01)

Protective effects of Qing-Re-Huo-Xue formula on bleomycin-induced pulmonary fibrosis through the p53/IGFBP3 pathway
by: Fangyong Yang, et al.
Published: (2023-03-01)

HuoXueTongFu Formula Alleviates Intraperitoneal Adhesion by Regulating Macrophage Polarization and the SOCS/JAK2/STAT/PPAR-γ Signalling Pathway
by: Min Zhao, et al.
Published: (2019-01-01)

HuoXueJieDu Formula Alleviates Diabetic Retinopathy in Rats by Inhibiting SOCS3-STAT3 and TIMP1-A2M Pathways
by: Hongliang Wang, et al.
Published: (2017-01-01)

Qi-Dong-Huo-Xue-Yin balances the immune microenvironment to protect against LPS induced acute lung injury
by: Tian zhao, et al.
Published: (2023-05-01)

Jian-Pi-Bu-Xue-Formula Alleviates Cyclophosphamide-Induced Myelosuppression via Up-Regulating NRF2/HO1/NQO1 Signaling
by: Qiuju Huang, et al.
Published: (2020-08-01)

Effect of Chinese herbal formulae (BU-SHEN-YI-QI granule) treatment on thrombin expression after ischemia/reperfusion
by: Aihua Liu, et al.
Published: (2023-12-01)

The Bushenhuoxue formula improves prothrombotic state in recurrent spontaneous abortion: network pharmacology and experimental validation
by: Xuan Yang, et al.
Published: (2025-08-01)

A Prospective Observational Study on the Effects of XingQi HuoXue Decoction on Gut Microbiota and Clinical Outcomes in Sepsis Patients with Acute Gastrointestinal Injury
by: Zhang J, et al.
Published: (2025-07-01)

Network pharmacology and the experimental findings of Bushenhuoxue formula for improving hippocampal neuron injury in vascular demented rats
by: Shan Luo, et al.
Published: (2021-12-01)

Evaluation of HuoXueHuaYu therapy for nonalcoholic fatty liver disease: a systematic review and meta-analysis of randomized controlled trial
by: Yunfei Cai, et al.
Published: (2019-07-01)

BuShenFang Suppresses Tumor Growth and Induces Apoptosis in Colorectal Cancer Xenografts
by: Khang Wen Goh, et al.
Published: (2025-09-01)

Network pharmacology-based mechanism prediction and pharmacological validation of Bushenhuoxue formula attenuating postmenopausal osteoporosis in ovariectomized mice
by: Chenjie Xia, et al.
Published: (2023-03-01)

Bushenhuoxue formula attenuates cartilage degeneration in an osteoarthritic mouse model through TGF-β/MMP13 signaling
by: Ping-er Wang, et al.
Published: (2018-03-01)

Gasdermin D could be lost in the brain parenchyma infarct core and a pyroptosis-autophagy inhibition effect of Jie-Du-Huo-Xue decoction after stroke
by: Chang Zhou, et al.
Published: (2024-07-01)

Dang-Gui-Bu-Xue decoction improves wound healing in diabetic rats by the activation of Notch signaling
by: Xian Zhang, et al.
Published: (2024-03-01)

Effects of Bu Shen Hua Zhuo formula on the LPS/TLR4 pathway and gut microbiota in rats with letrozole-induced polycystic ovary syndrome
by: Yang Wang, et al.
Published: (2022-08-01)

A network pharmacology approach to understanding the mechanisms of action of traditional medicine: Bushenhuoxue formula for treatment of chronic kidney disease.
by: Shao-hua Shi, et al.
Published: (2014-01-01)

Chinese herbal medicine (Bu-Shen-Tian-Jing Formula) for outcomes of IVF in Chinese patients with polycystic ovary syndrome: A retrospective cohort study
by: Xiaoming Pan, et al.
Published: (2022-03-01)

Efficacy and safety of Jian-Pi Huo-Xue granule for non-alcoholic fatty liver disease: study protocol for a randomized, double-blind, placebo-controlled trial
by: Yuanlong Sun, et al.
Published: (2022-06-01)

Implications of the anti-aging efficacy of BaZi Bu Shen capsules for human longevity and development
by: Zuohuan Meng, et al.
Published: (2025-10-01)

BushenHuoxue formula promotes osteogenic differentiation via affecting Hedgehog signaling pathway in bone marrow stem cells to improve osteoporosis symptoms
by: Yuqi Chen, et al.
Published: (2023-01-01)

Investigating the regulatory effect of Shen Qi Bu Qi powder on the gastrointestinal flora and serum metabolites in calves
by: Haochi Yang, et al.
Published: (2024-08-01)

First person – Qingran Huo
Published: (2025-07-01)

Bu-Shen-Tian-Jing formulas alleviate the mitochondrial damage induced by oxidative stress in ovarian granulosa cells exposed to DEHP through the HDAC3-HSP90AA pathway
by: Hui Zhang, et al.
Published: (2023-12-01)

Zi Shen Huo Luo Formula Enhances the Therapeutic Effects of Angiotensin-Converting Enzyme Inhibitors on Hypertensive Left Ventricular Hypertrophy by Interfering With Aldosterone Breakthrough and Affecting Caveolin-1/Mineralocorticoid Receptor Colocalization and Downstream Extracellular Signal-Regulated Kinase Signaling
by: Xiaotong Song, et al.
Published: (2020-04-01)

Efficacy of Yang Yin Sheng Xue formula against canine lymphoma chemotherapy-induced myelosuppression
by: Wanbing Pan, et al.
Published: (2025-08-01)

Corrigendum: The Therapeutic Effect of Huo Xue Tong Luo Capsules in Association Research Circulation Osseous (ARCO) Stage II Osteonecrosis of the Femoral Head: A Clinical Study With an Average Follow-up Period of 7.95 Years
by: Xiao-Ming He, et al.
Published: (2022-04-01)

Bu-Shen-Ning-Xin Decoction ameliorated the osteoporotic phenotype of ovariectomized mice without affecting the serum estrogen concentration or uterus
by: Wang L, et al.
Published: (2015-08-01)

Bu-Fei Yi-Shen Granules Reduce Acute Exacerbations in Patients with GOLD 3–4 COPD: A Randomized Controlled Trial
by: Yu XQ, et al.
Published: (2023-11-01)

Correction: Xue, S.; Shen, R. Corrosion-Fatigue Analysis of High-Strength Steel Wire by Experiment and the Numerical Simulation. <i>Metals</i> 2020, <i>10</i>, 734
by: Songling Xue, et al.
Published: (2021-06-01)

Mechanisms and Molecular Targets of BuShenHuoXue Formula for Osteoarthritis

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