Astragaloside IV alleviates GDM via regulating gut microbiota and gut microbiota metabolomic

BackgroundGestational diabetes mellitus (GDM), a severe pregnancy disorder, is a temporary form of diabetes that occurs during gestation. Astragaloside IV (AS IV), a natural and effective composition of Astragalus membranaceus, shows pharmacological effects against diabetes. On the contrary, the eff...

Full description

Bibliographic Details
Published in:	Frontiers in Pharmacology
Main Authors:	Fengge Wang, Yongning Zhu, Hua Shu, Xiaoyun Zhang, Liting Duan, Dongmei Man, Yanping Wang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Subjects:	gut microbiota gestational diabetes mellitus astragaloside IV metabolism gut microbiota-related metabolites
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1431240/full

Similar Items

Astragaloside IV alleviated bone loss in mice with ovariectomy-induced osteoporosis via modulating gut microbiota and fecal metabolism
by: Huichao Wang, et al.
Published: (2025-04-01)

Astragaloside IV Ameliorates Isoprenaline-Induced Cardiac Fibrosis in Mice via Modulating Gut Microbiota and Fecal Metabolites
by: Xu-Qin Du, et al.
Published: (2022-05-01)

Astragaloside IV ameliorates experimental autoimmune myasthenia gravis by regulating CD4 + T cells and altering gut microbiota
by: Senhui Weng, et al.
Published: (2023-08-01)

Astragaloside IV improves slow transit constipation by regulating gut microbiota and enterochromaffin cells
by: Xingyang Wan, et al.
Published: (2023-11-01)

Astragaloside IV ameliorate acute alcohol-induced liver injury in mice via modulating gut microbiota and regulating NLRP3/caspase-1 signaling pathway
by: Shan Wu, et al.
Published: (2023-12-01)

A novel microbial and hepatic biotransformation-integrated network pharmacology strategy explores the therapeutic mechanisms of bioactive herbal products in neurological diseases: the effects of Astragaloside IV on intracerebral hemorrhage as an example
by: En Hu, et al.
Published: (2023-04-01)

Astragaloside IV-PESV inhibits prostate cancer tumor growth by restoring gut microbiota and microbial metabolic homeostasis via the AGE-RAGE pathway
by: Xujun You, et al.
Published: (2024-04-01)

Astragaloside IV alleviates lipopolysaccharide‐induced preeclampsia‐like phenotypes via suppressing the inflammatory responses
by: Dilihuma Tuerxun, et al.
Published: (2021-03-01)

Research progress of gut microbiota in the pathogenesis of gestational diabetes mellitus
by: HU Xian-liang, WAN Yan, FENG Ji
Published: (2022-03-01)

Astragaloside IV, as a potential anticancer agent
by: Dongqin Xia, et al.
Published: (2023-02-01)

Gut Microbiota-brain Axis
by: Hong-Xing Wang, et al.
Published: (2016-01-01)

Insomnia and Gut Microbiota
by: Nazime Mercan Doğan, et al.
Published: (2024-03-01)

Gut Microbiota and Alzheimer Disease
by: Lester Raymundo Dominguez Huarcaya
Published: (2025-01-01)

GUT MICROBIOTA AND CARDIOVASCULAR RISK FACTORS. PART 1. GUT MICROBIOTA, AGE AND SEX
by: D. A. Kashtanova, et al.
Published: (2015-08-01)

Integrated Metabolome and Microbiome Analysis Reveals the Regulatory Effects of Fermented Soybean Meal on the Gut Microbiota of Late Gestation
by: Yantao Li, et al.
Published: (2025-05-01)

Fecal Microbiota Transplantation Beneficially Regulates Intestinal Mucosal Autophagy and Alleviates Gut Barrier Injury
by: Saisai Cheng, et al.
Published: (2018-10-01)

Gut microbiota and serum metabolomic alterations in modulating the impact of fecal microbiota transplantation on ciprofloxacin-induced seizure susceptibility
by: Shangnan Zou, et al.
Published: (2024-06-01)

Editorial: Dietary modulation of gut microbiota-X axis
by: Bowen Li, et al.
Published: (2025-09-01)

Gut Microbiota across Normal Gestation and Gestational Diabetes Mellitus: A Cohort Analysis
by: Patricia M. Dualib, et al.
Published: (2022-08-01)

Retraction: Human gut microbiota: dysbiosis and manipulation
by: Frontiers in Microbiology
Published: (2013-12-01)

Effects of the Gut Microbiota and Barrier Function on Melatonin Efficacy in Alleviating Liver Injury
by: Hao Zhang, et al.
Published: (2022-08-01)

Mechanisms linking gut microbiota to depression
by: A. Fraga, et al.
Published: (2021-04-01)

Targeting the Gut Microbiota to Treat Cachexia
by: Laurence Genton, et al.
Published: (2019-09-01)

Astragaloside IV alleviates inflammation and improves myocardial metabolism in heart failure mice with preserved ejection fraction
by: Xiao Wang, et al.
Published: (2024-11-01)

Origin of the neonatal gut microbiota and probiotic intervention: a randomized controlled trial
by: Zhe Li, et al.
Published: (2024-04-01)

Astragaloside-IV Alleviates Heat-Induced Inflammation by Inhibiting Endoplasmic Reticulum Stress and Autophagy
by: Zhiwei Dong, et al.
Published: (2017-06-01)

Imbalance of gut microbiota in gestational diabetes
by: Weiyi Shen, et al.
Published: (2024-04-01)

Sialic acid exacerbates gut dysbiosis-associated mastitis through the microbiota-gut-mammary axis by fueling gut microbiota disruption
by: Caijun Zhao, et al.
Published: (2023-04-01)

The Role of Gut Microbiota in Obesity
by: Durma Anna Celina, et al.
Published: (2024-03-01)

Correlations between gut microbiota and serum metabolomics in patients with neurogenic rosacea
by: Min Li, et al.
Published: (2025-07-01)

The interaction between oral microbiota and gut microbiota in atherosclerosis
by: Xinsi Li, et al.
Published: (2024-06-01)

Repairing gut barrier by traditional Chinese medicine: roles of gut microbiota
by: Yaochuan Zhou, et al.
Published: (2024-07-01)

The role of gut microbiota in diarrhea and its alleviation through microbiota-targeted interventions
by: Rui Tian, et al.
Published: (2025-10-01)

Matrine alleviates depressive-like behaviors via modulating microbiota–gut–brain axis in CUMS-induced mice
by: Ming Zhang, et al.
Published: (2023-02-01)

The interplay between oral microbiota, gut microbiota and systematic diseases
by: Xiujun Tan, et al.
Published: (2023-12-01)

How informative is the mouse for human gut microbiota research?
by: Thi Loan Anh Nguyen, et al.
Published: (2015-01-01)

Astragaloside IV: a potential nemesis for gastric cancer
by: Chao Hu, et al.
Published: (2025-07-01)

Exploring the role of gut microbiota in Parkinson’s disease: insights from fecal microbiota transplantation
by: Mengqi Guo, et al.
Published: (2025-06-01)

Gut Microbiota and Immune System Interactions
by: Ji Youn Yoo, et al.
Published: (2020-10-01)

Alterations in gut microbiota and metabolomic profiles in acute stroke: insights into brain–gut axis dysregulation
by: Jiajing Chen, et al.
Published: (2025-08-01)