<i>Gastrodia elata</i> Blume and <i>Zanthoxylum schinifolium</i> Siebold & Zucc Mixed Extract Suppress Platelet Aggregation and Thrombosis

• Published in: Medicina
• Main Authors: Yong-Deok Jeon, Ji-Hyun Lee, Mi-Ran Park, Ji-Ye Lim, Sa-Haeng Kang, Dae-Ki Kim, Young-Mi Lee
• Format: Article
• Language: English
• Published: MDPI AG 2021-10-01
• Subjects: <i>Gastrodia elata</i> blume; <i>Zanthoxylum schinifolium</i> Siebold & Zucc; platelet aggregation; thrombosis; anticoagulation; antithrombotic
• Online Access: https://www.mdpi.com/1648-9144/57/10/1128
• ISSN: 1010-660X; 1648-9144

<i>Background and objectives:</i> Blood vessel thrombosis causes blood circulation disorders, leading to various diseases. Currently, various antiplatelet and anticoagulant drugs, such as aspirin, warfarin, heparin, and non-vitamin K antagonist oral anticoagulants (NOACs), are used as the major drugs for the treatment of a wide range of thrombosis. However, these drugs have a side effect of possibly causing internal bleeding due to poor hemostasis when taken for a long period of time. <i>Materials and Methods:</i> <i>Gastrodia elata</i> Blume (GE) and <i>Zanthoxylum schinifolium</i> Siebold & Zucc (ZS) are known to exhibit hemostatic and antiplatelet effects as traditional medicines that have been used for a long time. In this study, we investigated the effect of a mixed extract of GE and ZS (MJGE09) on platelet aggregation and plasma coagulation. <i>Results:</i> We found that MJGE09 inhibited collagen-and ADP-induced platelet aggregation <i>in vitro</i>. In addition, collagen- and ADP-induced platelet aggregation were also inhibited in a dose-dependent manner on the platelets of mice that were orally administered MJGE09 <i>ex vivo</i>. However, compared with aspirin, MJGE09 did not prolong the rat tail vein bleeding time in vivo and did not show a significant effect on the increase in the prothrombin time (PT) and activated partial thromboplastin time (aPTT). <i>Conclusions:</i> These results suggest that MJGE09 can be used as a potential anticoagulant with improved antithrombotic efficacy.