Hand, foot and mouth disease and herpangina caused by enterovirus A71 infections: a review of enterovirus A71 molecular epidemiology, pathogenesis, and current vaccine development

ABSTRACT Enterovirus A71 (EV-A71) infections are one of the main etiological agents of hand, foot and mouth disease (HFMD) and herpangina worldwide. EV-A71 infection is a life-threatening communicable disease and there is an urgent global need for the development of vaccines for its prevention and c...

Full description

Bibliographic Details
Published in:	Revista do Instituto de Medicina Tropical de São Paulo
Main Authors:	Yu-Kang Chang, Kou-Huang Chen, Kow-Tong Chen
Format:	Article
Language:	English
Published:	Universidade de São Paulo (USP) 2018-11-01
Subjects:	Hand, foot and mouth disease Herpangina Enterovirus A71 Vaccine
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652018005000402&lng=en&tlng=en

Similar Items

Immunopathogenesis and Virus–Host Interactions of Enterovirus 71 in Patients with Hand, Foot and Mouth Disease
by: Jonathan A. Cox, et al.
Published: (2017-11-01)

Enterovirus 71–associated Hand, Foot, and Mouth Disease, Southern Vietnam, 2011
by: Truong Huu Khanh, et al.
Published: (2012-12-01)

Epidemiological and etiological characteristics of herpangina and hand foot mouth diseases in Jiangsu, China, 2013–2014
by: Xin Yao, et al.
Published: (2017-04-01)

Enterovirus 71 infection: An experience in Korea, 2009
by: Kyung Hyo Kim
Published: (2010-05-01)

Enterovirus 71 Outbreak, Brunei
by: Sazaly AbuBakar, et al.
Published: (2009-01-01)

Receptors for enterovirus 71
by: Seiya Yamayoshi, et al.
Published: (2014-01-01)

Enterovirus A71 Vaccines
by: Mei-Ling Li, et al.
Published: (2021-02-01)

A prospective, comparative study of severe neurological and uncomplicated hand, foot and mouth forms of paediatric enterovirus 71 infections
by: Yoann Crabol, et al.
Published: (2017-06-01)

Hand, Foot and Mouth Disease Caused by Coxsackievirus A6, Thailand, 2012
by: Jiratchaya Puenpa, et al.
Published: (2013-04-01)

Molecular epidemiology of human enterovirus 71 at the origin of an epidemic of fatal hand, foot and mouth disease cases in Cambodia
by: Veasna Duong, et al.
Published: (2016-01-01)

Enterovirus A71 Infection and Neurologic Disease, Madrid, Spain, 2016
by: Pascal Del Giudice
Published: (2020-07-01)

Emerging Enterovirus A71 Subgenogroup B5 Causing Severe Hand, Foot, and Mouth Disease, Vietnam, 2023
by: Nguyen Van Vinh Chau, et al.
Published: (2024-02-01)

Effectiveness of Enterovirus 71 inactivated vaccines against hand, foot, and mouth disease: A test-negative case-control study
by: Yutong Zhang, et al.
Published: (2024-12-01)

Hand, Foot, and Mouth Disease Caused by Coxsackievirus A6, Japan, 2011
by: Tsuguto Fujimoto, et al.
Published: (2012-02-01)

Enterovirus A71 vaccine effectiveness in preventing enterovirus A71 infection among medically-attended hand, foot, and mouth disease cases, Beijing, China
by: Xiaoli Wang, et al.
Published: (2019-05-01)

Evaluation of enterovirus A71 vaccine effectiveness against pediatric hand, foot, and mouth disease caused by enterovirus A71 virus in Tianjin, China, 2016–2023: A test-negative design case-control study
by: Lu Gao, et al.
Published: (2025-12-01)

Characterization of Coxsackievirus A6- and Enterovirus 71-associated Hand Foot and Mouth disease in Beijing, China, from 2013 to 2015
by: Jie eLi, et al.
Published: (2016-03-01)

Enterovirus 71 in Taiwan
by: Luan-Yin Chang
Published: (2008-08-01)

Development of Novel Vaccines against Enterovirus-71
by: Pinn Tsin Isabel Yee, et al.
Published: (2015-12-01)

Identification of the Emerging C1-like Lineage of Enterovirus A71 in Two Uruguayan Children with Hand-Foot-and-Mouth Disease and Neurological Complications
by: Andrés Lizasoain, et al.
Published: (2024-11-01)

Cellular receptors for enterovirus A71
by: Kyousuke Kobayashi, et al.
Published: (2020-01-01)

Genetic Diversity of Enterovirus A71, India
by: Vinay K. Saxena, et al.
Published: (2015-01-01)

Modelling person-to-person transmission in an Enterovirus A71 orally infected hamster model of hand-foot-and-mouth disease and encephalomyelitis
by: Win Kyaw Phyu, et al.
Published: (2017-01-01)

Epidemiological characteristics of hand, foot and mouth disease in Shenzhen from 2008 to 2020 and effect of inactivated EV71 vaccine on disease incidence
by: Zhao-yi LIANG, et al.
Published: (2023-02-01)

Clinical characteristics and managements of severe hand, foot and mouth disease caused by enterovirus A71 and coxsackievirus A16 in Shanghai, China
by: Kang Cai, et al.
Published: (2019-03-01)

Molecular epidemiology and phylodynamic analysis of enterovirus 71 in Beijing, China, 2009–2019
by: Jie Li, et al.
Published: (2023-11-01)

The epidemiological characteristics of enterovirus infection before and after the use of enterovirus 71 inactivated vaccine in Kunming, China
by: Hongchao Jiang, et al.
Published: (2021-01-01)

Development and characterization of an enterovirus 71 (EV71) virus-like particles (VLPs) vaccine produced in Pichia pastoris
by: Zhijian Yang, et al.
Published: (2020-07-01)

Novel Anti-Enterovirus A71 Compounds Discovered by Repositioning Antivirals from the Open-Source MMV Pandemic Response Box
by: Nattinee Lochaiyakun, et al.
Published: (2024-06-01)

Molecular epidemiology and clinical features of hand, foot and mouth disease requiring hospitalization after the use of enterovirus A71 inactivated vaccine in chengdu, China, 2017-2022: a descriptive study
by: Xiaoxia Duan, et al.
Published: (2022-12-01)

Long-Term Immunogenicity Study of an Aluminum Phosphate-Adjuvanted Inactivated Enterovirus A71 Vaccine in Children: An Extension to a Phase 2 Study
by: Nan-Chang Chiu, et al.
Published: (2024-08-01)

Enterovirus 71-Associated Infection in South Vietnam: Vaccination Is a Real Solution
by: Natalia I. Romanenkova, et al.
Published: (2023-05-01)

Seroprevalence of antibodies to enterovirus 71 and coxsackievirus A16 among people of various age groups in a northeast province of Thailand
by: Hatairat Lerdsamran, et al.
Published: (2018-10-01)

Safety and immunogenicity of an experimental live combination vaccine against enterovirus 71 and coxsackievirus A16 in rhesus monkeys
by: Ting Yang, et al.
Published: (2020-07-01)

Enterovirus-A71 exploits RAB11 to recruit chaperones for virus morphogenesis
by: Qing Yong Ng, et al.
Published: (2024-06-01)

Substitution of Coxsackievirus A16 VP1 BC and EF Loop Altered the Protective Immune Responses in Chimera Enterovirus A71
by: Xiu Hui Tan, et al.
Published: (2023-08-01)

EV-A71 vaccine licensure: a first step for multivalent enterovirus vaccine to control HFMD and other severe diseases
by: Qunying Mao, et al.
Published: (2016-01-01)

Effect of EV71 Vaccination on Transmission Dynamics of Hand, Foot, and Mouth Disease and Its Epidemic Prevention Threshold
by: Dashan Zheng, et al.
Published: (2024-10-01)

Recombinant Enterovirus 71 Viral Protein 1 Fused to a Truncated Newcastle Disease Virus NP (NPt) Carrier Protein
by: Suhaili Mustafa, et al.
Published: (2020-12-01)

A comparative study of multiple clinical enterovirus 71 isolates and evaluation of cross protection of inactivated vaccine strain FY-23 K-B in vitro
by: Ting Yang, et al.
Published: (2017-10-01)