Treg-specific deletion of the phosphatase SHP-1 impairs control of inflammation in vivo

IntroductionTo achieve a healthy and functional immune system, a delicate balance exists between the activation of conventional T cells (Tcon cells) and the suppression by regulatory T cells (Treg). The tyrosine phosphatase SHP-1, a negative regulator of TCR signaling, shapes this ‘activation-suppre...

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Bibliographic Details
Published in:	Frontiers in Immunology
Main Authors:	QinLei Gu, Kenneth S. Tung, Ulrike M. Lorenz
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-03-01
Subjects:	SHP-1 tyrosine phosphatase regulatory T cells T cell signaling inflammatory disease
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1139326/full

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