Roxadustat for ESA‐Hyporesponsive Renal Anemia in a 13‐Year‐Old on Hemodialysis: Case Report and Mini‐Review

ABSTRACT Anemia is the most common complication of end‐stage renal disease (ESRD). While erythropoiesis‐stimulating agents (ESA) have improved treatment outcomes, some patients exhibit intolerance or hyporesponsiveness. Roxadustat, a hypoxia‐inducible factor prolyl hydroxylase inhibitor (HIF‐PHI), i...

Full description

Bibliographic Details
Published in:	Clinical Case Reports
Main Authors:	Meng Zhang, Yanchao Guo, Yan Zhu, Juan Yang
Format:	Article
Language:	English
Published:	Wiley 2025-10-01
Subjects:	adolescent anemia prolyl‐hydroxylase inhibitors renal dialysis Roxadustat
Online Access:	https://doi.org/10.1002/ccr3.70985

Similar Items

Randomized Study on the Efficacy of Standard Versus Low Roxadustat Dose for Anemia in Patients on Peritoneal Dialysis
by: Zhikai Yang, et al.
Published: (2022-03-01)

Research progress on roxadustat treatment for renal anemia
by: HU Bao-li, HU Bin
Published: (2022-09-01)

A retrospective study on the efficacy of Roxadustat in peritoneal dialysis patients with erythropoietin hyporesponsiveness
by: Jie Liu, et al.
Published: (2024-05-01)

Case report: Roxadustat overdose in an anemia patient of chronic kidney disease: insight beyond insignificant consequence
by: Long-Guang Zhang, et al.
Published: (2024-08-01)

Roxadustat in CKD and transplant patients: A new era in anemia management
by: Muhammad Tassaduq Khan, et al.
Published: (2025-03-01)

Issues on clinical application of hypoxia-inducible factor prolyl hydroxylase inhibitor Roxadustat
by: TU Yan, et al.
Published: (2020-01-01)

Effectiveness and Safety of Roxadustat for Renal Anemia in Dialysis-dependent Chronic Kidney Disease: a Meta-analysis
by: LI Jiaqing, YANG Qing, YUAN Dunlu, HUANG Jingjing, CHANG Qing, NIE Jingwen, ZHOU Zhu, LI Qing
Published: (2023-02-01)

A Case Report of Hypothyrotropin Hypothyroidism Caused by Roxadustat
by: YAN Xuelian, et al.
Published: (2025-03-01)

Roxadustat on Renal Anemia with Macroinflammation: A Retrospective Cohort Study
by: Yan Tu, et al.
Published: (2024-03-01)

The Effect of Roxadustat on Transfusion-Dependent Myelodysplastic Syndrome Complicated by Chronic Kidney Disease
by: Ryujiro Hara, et al.
Published: (2021-11-01)

Influencing factors of clinical efficacy of roxadustat among hemodialysis patients
by: Wenhui Wu, et al.
Published: (2024-12-01)

The role of roxadustat in chronic kidney disease patients complicated with anemia
by: Jie Liu, et al.
Published: (2023-03-01)

Roxadustat has risks of reversible central hypothyroidism in patients undergoing hemodialysis: a single-center retrospective cohort study
by: Emiko Otsuka, et al.
Published: (2024-12-01)

Thyroid function analysis after roxadustat or erythropoietin treatment in patients with renal anemia: a cohort study
by: Xiaomeng Zheng, et al.
Published: (2023-12-01)

Roxadustat: Not just for anemia
by: Xiaoyu Zhu, et al.
Published: (2022-08-01)

Effect of roxadustat on lowering blood lipids in peritoneal dialysis patients with anemia
by: Tian Xu, et al.
Published: (2025-12-01)

Roxadustat for Patients with Posttransplant Anemia: A Narrative Review
by: Xiaoxiao Tang, et al.
Published: (2023-11-01)

Impact of roxadustat on anemia management in infected patients undergoing long-term dialysis: a retrospective cohort analysis
by: Lulu Wang, et al.
Published: (2025-10-01)

The efficacy and safety of roxadustat for anemia in patients with dialysis-dependent chronic kidney disease: a systematic review and meta-analysis
by: Qiaoqiao Zhou, et al.
Published: (2023-12-01)

Low cholesterol levels are good markers for central hypothyroidism in case with dialysis using roxadustat
by: Serina Kita, et al.
Published: (2024-09-01)

Study on HIF-PHI combined with iron supplement in treatment of renal anemia in rats
by: Zhaoli Gao, et al.
Published: (2025-03-01)

Roxadustat as a Hypoxia-Mimetic Agent: Erythropoietic Mechanisms, Bioanalytical Detection, and Regulatory Considerations in Sports Medicine
by: Elena-Christen Creangă, et al.
Published: (2025-09-01)

Safety of Roxadustat in Chronic Kidney Disease Patients: An Updated Systematic Review and Meta-Analysis
by: Patricia Martínez-Miguel, et al.
Published: (2025-10-01)

Roxadustat for the Treatment of Early Post-Transplantation Anemia
by: Louis Guenal, et al.
Published: (2025-10-01)

Clinical efficacy and safety analysis in initial hemodialysis patient with renal anemia treated by roxadustat or recombinant human erythropoietin
by: Zhang Peng-jie, et al.
Published: (2022-11-01)

Plasma phospholipids profiling changes were associated with the therapeutic response to Roxadustat in peritoneal dialysis patients
by: Ya-Hui Yang, et al.
Published: (2023-12-01)

Dysfunction of von-Hippel Lindau factor causes reduced degradation of HIF leading to renal cancer. Hypoxia-inducible factor-prolyl hydroxylase enzyme inhibitors also lessen HIF destruction and could therefore increase renal cancer
by: Helge Waldum
Published: (2023-06-01)

Effect of roxadustat on iron metabolism in patients with peritoneal dialysis: a real-world 24-week study
by: Xuejie Zhang, et al.
Published: (2023-11-01)

Roxadustat: Do we know all the answers?
by: Qiu-Yu Li, et al.
Published: (2023-05-01)

Short-term effect of low-dose roxadustat combined with erythropoiesis-stimulating agent treatment for erythropoietin-resistant anemia in patients undergoing maintenance hemodialysis
by: Qiaoying Xu, et al.
Published: (2024-07-01)

The Efficacy and Safety of Roxadustat for the Treatment of Posttransplantation Anemia: A Randomized Study
by: Weiwei Kong, et al.
Published: (2024-06-01)

The Efficacy and Safety of Roxadustat for Anemia in Hemodialysis Patients with Chronic Kidney Disease: A Meta-Analysis of Randomized Controlled Trials
by: Yunling Geng, et al.
Published: (2024-11-01)

Roxadustat for the treatment of anemia in patients with chronic kidney disease: a Meta-analysis
by: WANG Rui, et al.
Published: (2019-01-01)

Research progress on treatment of renal anemia in patients with chronic kidney disease
by: Li Yudong, Liao Wenjian, Luo Yonghang, Chen Qiuyu, Su Yong
Published: (2023-05-01)

Roxadustat promotes allograft recovery after kidney transplantation: A prospective, multicenter, randomized controlled trial
by: Mao-Lin Ma, et al.
Published: (2025-08-01)

Hypertension Induced by Hypoxia‐Inducible Factor Prolyl Hydroxylase Inhibitors in Treating Anemia in Patients With Chronic Kidney Disease: A Mini‐Review
by: Wei Zhang, et al.
Published: (2024-12-01)

Randomized Trial of Lower-Dose Roxadustat Efficacy and Safety in Non–Dialysis-Dependent CKD-Associated Anemia
by: Ping Li, et al.
Published: (2025-04-01)

A nomogram for predicting the risk of treatment failure of roxadustat in peritoneal dialysis with renal anemia
by: Jiangqing Fan, et al.
Published: (2024-04-01)

Roxadustat alleviates the inflammatory status in patients receiving maintenance hemodialysis with erythropoiesis-stimulating agent resistance by increasing the short-chain fatty acids producing gut bacteria
by: Xiu-Nan Zhao, et al.
Published: (2023-07-01)

The Efficacy and Safety of Roxadustat for Anemia in Patients With Chronic Kidney Disease: A Meta-Analysis
by: Lijun Wang, et al.
Published: (2022-04-01)