Synthesis and anti-inflammatory activity of some new 1,3,4-thiadiazoles containing pyrazole and pyrrole nucleus
A new series of 1,3,4-thiadiazole with pyrazole-3-carboxamides (3a–f) and pyrrole-3-carboxamide (4a–f) moiety are prepared using intermediate compounds 1,3,4-thiadiazolacrylamides (2a–f). The structures of newly synthesized compounds were confirmed on the basis of their 1H NMR, 13C NMR, LCMS mass, F...
| Published in: | Journal of Saudi Chemical Society |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Published: |
Springer
2016-09-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319610312001743 |
| _version_ | 1848652375510745088 |
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| author | S. Maddila S. Gorle Ch. Sampath P. Lavanya |
| author_facet | S. Maddila S. Gorle Ch. Sampath P. Lavanya |
| author_sort | S. Maddila |
| collection | DOAJ |
| container_title | Journal of Saudi Chemical Society |
| description | A new series of 1,3,4-thiadiazole with pyrazole-3-carboxamides (3a–f) and pyrrole-3-carboxamide (4a–f) moiety are prepared using intermediate compounds 1,3,4-thiadiazolacrylamides (2a–f). The structures of newly synthesized compounds were confirmed on the basis of their 1H NMR, 13C NMR, LCMS mass, FT-IR and elemental analysis data results. Among all the compounds (12), seven compounds were found to exhibit significant anti-inflammatory activity with 77.27, 75.89, 76.24, 68.55, 63.72, 57.41, 53.05% and 81.00, 80.55, 78.62, 71.45, 68.95, 61.89, 56.32% inhibition in paw edema at 3 h and 5 h respectively, compared to the standard drug indomethacin (74.82 and 80.32% at 3 h and 5 h). Compounds 3c, 3d and 4c exhibited potent activity than standard drug. |
| format | Article |
| id | doaj-d4fc3d0d2ce34308bb94e187091f58de |
| institution | Directory of Open Access Journals |
| issn | 1319-6103 |
| language | English |
| publishDate | 2016-09-01 |
| publisher | Springer |
| record_format | Article |
| spelling | doaj-d4fc3d0d2ce34308bb94e187091f58de2025-11-02T22:53:02ZengSpringerJournal of Saudi Chemical Society1319-61032016-09-0120S1S306S31210.1016/j.jscs.2012.11.007Synthesis and anti-inflammatory activity of some new 1,3,4-thiadiazoles containing pyrazole and pyrrole nucleusS. Maddila0S. Gorle1Ch. Sampath2P. Lavanya3School of Chemistry, University of KwaZulu-Natal, West Ville Campus, Chilten Hills, Durban 4000, South AfricaSchool of Biochemistry, University of KwaZulu-Natal, West Ville Campus, Chilten Hills, Durban 4000, South AfricaDepartment of Chemistry, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, IndiaDepartment of Chemistry, Annamacharya Institute of Technology & Sciences, J.N.T. University, Tirupati 517 502, Andhra Pradesh, IndiaA new series of 1,3,4-thiadiazole with pyrazole-3-carboxamides (3a–f) and pyrrole-3-carboxamide (4a–f) moiety are prepared using intermediate compounds 1,3,4-thiadiazolacrylamides (2a–f). The structures of newly synthesized compounds were confirmed on the basis of their 1H NMR, 13C NMR, LCMS mass, FT-IR and elemental analysis data results. Among all the compounds (12), seven compounds were found to exhibit significant anti-inflammatory activity with 77.27, 75.89, 76.24, 68.55, 63.72, 57.41, 53.05% and 81.00, 80.55, 78.62, 71.45, 68.95, 61.89, 56.32% inhibition in paw edema at 3 h and 5 h respectively, compared to the standard drug indomethacin (74.82 and 80.32% at 3 h and 5 h). Compounds 3c, 3d and 4c exhibited potent activity than standard drug.http://www.sciencedirect.com/science/article/pii/S13196103120017431,3,4-Acrylamides1,3,4-ThiadiazolesPyrrole-3-carboxamidesPyrazole-3-carboxamidesAnti-inflammatory activity |
| spellingShingle | S. Maddila S. Gorle Ch. Sampath P. Lavanya Synthesis and anti-inflammatory activity of some new 1,3,4-thiadiazoles containing pyrazole and pyrrole nucleus 1,3,4-Acrylamides 1,3,4-Thiadiazoles Pyrrole-3-carboxamides Pyrazole-3-carboxamides Anti-inflammatory activity |
| title | Synthesis and anti-inflammatory activity of some new 1,3,4-thiadiazoles containing pyrazole and pyrrole nucleus |
| title_full | Synthesis and anti-inflammatory activity of some new 1,3,4-thiadiazoles containing pyrazole and pyrrole nucleus |
| title_fullStr | Synthesis and anti-inflammatory activity of some new 1,3,4-thiadiazoles containing pyrazole and pyrrole nucleus |
| title_full_unstemmed | Synthesis and anti-inflammatory activity of some new 1,3,4-thiadiazoles containing pyrazole and pyrrole nucleus |
| title_short | Synthesis and anti-inflammatory activity of some new 1,3,4-thiadiazoles containing pyrazole and pyrrole nucleus |
| title_sort | synthesis and anti inflammatory activity of some new 1 3 4 thiadiazoles containing pyrazole and pyrrole nucleus |
| topic | 1,3,4-Acrylamides 1,3,4-Thiadiazoles Pyrrole-3-carboxamides Pyrazole-3-carboxamides Anti-inflammatory activity |
| url | http://www.sciencedirect.com/science/article/pii/S1319610312001743 |
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